Inventors:
Marion W. Anders - Pittsford NY, US
James L. Robotham - Seattle WA, US
Shey-Shing Sheu - Pittsford NY, US
Paul Spencer Brookes - Rochester NY, US
Jalil Shojaie - Rochester NY, US
Leif Olson - Riverside RI, US
Richard L. Parton - Webster NY, US
Assignee:
University of Rochester - Rochester NY
International Classification:
A01N 43/50, A01N 43/32, A01N 43/26, A01N 43/16, A01N 31/14, A61K 31/415, A61K 31/385, A61K 31/35, A61K 31/075, A61K 31/08, C07D 339/00, C07D 339/02, C07D 341/00, C07D 409/00, C07D 239/00, C07D 239/02
US Classification:
514385, 514436, 514440, 514456, 514720, 514722, 549 20, 549 35, 544242
Abstract:
The present invention is a mitochondria-targeted antioxidant prodrug useful for the prevention or treatment of diseases or conditions associated with mitochondrial dysfunction resulting from changes in the mitochondrial redox environment. Antioxidant prodrugs of the invention are produced by modifying an antioxidant to a fatty acid so that the resulting prodrug is targeted to and activated by an enzyme of mitochondrial fatty acid beta-oxidation.