Inventors:
Michael G. Rosenblum - Houston TX
James L. Murray - Houston TX
Peter J. Kelleher - The Woodlands TX
Robert A. Newman - Houston TX
Abdul R. Khokhar - Houston TX
Assignee:
Board of Regents, The University of Texas System - Austin TX
International Classification:
A61K 3940, A61K 3942, A61K 3944, C12N 500
Abstract:
The present invention relates to monoclonal antibodies specifically binding platinum (II) complex. The monoclonal antibodies of the present invention are characteristically produced by antibody-producing cell lines such as hybridomas. These cell lines may result, for example, from fusion of a neoplastic cell with an antibody-producing animal cell obtained from an animal immunized against a platinum (II) complex. The cellular fusion products include cell lines forming monoclonal antibody specifically binding platinum (II) complex in competition with an antibody produced by: hybridoma strain 1C. sub. 1 H. sub. 2 A. sub. 5, deposited with the American Type Culture Collection, Rockville, MD on May 1, 1987 and having ATCC accession number HB 9411; strain 3A. sub. 2 A. sub. 1 ; strain 1A. sub. 6 A. sub. 2 ; strain 3A. sub. 6 B. sub.