Inventors:
Ralph Scannell - Hopkinson MA
Pierre Chatelain - Pierre, BE
Anna Toy-Palmer - Arlington MA
Edmond Differding - Louvain-La-Neuve, BE
James Ellis - Boxford MA
Marie-Agnes Lassoie - Brainele-Chateau, BE
Xiong Cai - Belmont MA
Sajjat Hussoin - Lexington MA
Gurmit Grewal - Natick MA
Timothy Lewis - Framingham MA
International Classification:
A61K 31495
US Classification:
51425303, 5142541, 51425504, 514290, 514318, 514325, 514326, 514331, 544361, 544379, 544380, 544396, 546 93, 546203, 546231, 546234
Abstract:
The present invention provides 1,4 substituted piperazines, 1,4 substituted piperidines, and 1-substituted, 4-alkylidenyl peperidines compounds. The compounds of the invention are dual acting molecules having both leukotriene inhibition properties as well as antihistaminergic properties. The compounds of the invention are useful for treating conditions in which there is likely to be a histamine and/or leukotriene component. These conditions include preferable asthma, seasonal and perennial allergic rhinitis, sinusitus, conjunctivitis, food allergy, scombroid poisoning, psoriasis, urticaria, pruritus, eczema, rheumatoid arthritis, inflammatory bowel disease, chronic obstructive pulmonary disease, thrombotic disease and otitis media. Also provided are methods of treating asthma and rhinitis by administering an effective asthma and rhinitis-relieving amount of the compounds to a subject in need thereof.