Inventors:
Alan R. Fritzberg - Olga WA, US
Paul G. Abrams - Seattle WA, US
Lauren Marie Tatalick - Redmond WA, US
Kent R. Thoelke - Seattle WA, US
James Kyle Bryan - Seattle WA, US
Mark D. Hylarides - Stanwood WA, US
Elizabeth K. John - San Diego CA, US
Assignee:
NEORX Corporation - Seattle WA
International Classification:
A61K 51/00, A61M 36/14
US Classification:
424 165, 424 111, 424 91, 534 15
Abstract:
The present invention relates to a method of suppressing bone marrow (BM) and treating conditions that arise in or near bone such as cancer, myeloproliferative diseases, autoimmune diseases, infectious diseases, metabolic diseases or genetic diseases, with compositions having as their active ingredient a radionuclide complexed with a chelating agent such as macrocyclic aminophosphonic acid.