Inventors:
John P. McKearn - Glencoe MO, US
Gary Gordon - Highland IL, US
James J. Cunningham - Chicago IL, US
Stephen T. Gately - Palatine IL, US
Alane T. Koki - Beaufort MO, US
Jaime L. Masferrer - Ballwin MO, US
Assignee:
G. D. Searle & Co. - Chicago IL
International Classification:
A61K031/33, A61K031/445, C07D295/00, C07D211/00, C07D417/00
US Classification:
514183, 5142275, 5142278, 514283, 514318, 514319, 514321, 514330, 544 59, 544 60, 546 48, 546238, 546263
Abstract:
A method of using an MMP inhibitor and optionally radiation therapy, and one or more antineoplastic agents of the topoisomerase class selected from the group consisting of irinotecan and topotecan, as a combination therapy for the treatment of neoplasia is disclosed.