DR. JAMES H MCKERROW, MD
Medical Practice at Parnassus Ave, San Francisco, CA

6548521, Apr 15, 2003

Jul 28, 2000

09/628080

Fred Ehrenkranz Cohen - San Francisco CA
James Hobson McKerrow - San Francisco CA
Christine Sun Ring - San Francisco CA
Philip Jon Rosenthal - Nicasio CA
George Lommel Kenyon - San Francisco CA
Zhe Li - San Francisco CA

The Regents of the University of California - Oakland CA

A61K 31404

514354, 514248, 514307, 514311, 514399, 514355, 514419, 514457

Compositions and methods for treating a patient infected with a metazoan parasite by inhibiting the enzymatic action of the metazoan parasite protease, wherein there is employed at least one compound of formula I wherein A is a substituted or unsubstituted homoaromatic or heteroaromatic ring system comprising one to three rings which binds to at least one of the S2, S1 and S1′ subsites; B is a substituted or unsubstituted homoaromatic or heteroaromatic ring system comprising one to three rings which binds to at least one of the S1′, S1 and S2 subsites; and X is —C C—C( O)—. These compositions and methods have particular utility in the treatment of schistosomiasis, malaria, and other infectious diseases.

6800615, Oct 5, 2004

Dec 12, 2002

10/317906

Robert H. Cichewicz - Santa Cruz CA
Muraleedharan G. Nair - Okemos MI
James H. McKerrow - San Francisco CA

Board of Trustees of Michigan State University - East Lansing MI
The Regent of the University of California - Oakland CA
The United States of America as represented by the Department of Veterans Affairs - Washington DC

A01K 4304

514 33, 514510, 514548, 552208, 552261, 552262, 552265, 552266, 552267

Anthraquinones are described which are antihelminthic and in particular, are useful in compositions for inhibiting Schistosoma sp. in vitro or in vivo. The preferred anthraquinones have the formula: wherein R , R , R , and R are each hydrogen, hydroxy, halogen, alkyl, substituted alkyl, alkene, substituted alkene, alkyne, aryl, substituted aryl, cyclic, substituted cyclic, acid group, carbohydrate, or combination thereof, R is a group containing 1 to 12 carbons such as methyl, alkyl, substituted alkyl, aldehyde, hydroxy, hydroxymethyl, acid group, carbohydrate, or combination thereof, and the halogen is I, F, Br, or Cl.

4762789, Aug 9, 1988

Jan 16, 1986

6/819892

William E. Keene - Berkeley CA
James H. McKerrow - San Francisco CA

The University of California - Berkeley CA

C12N 950, C12N 1500, C12Q 100, G01N 3354

435219

The present invention is a composition of matter composed essentially of a purified homogeneous thiol proteinase secreted by Entamoeba histolytica trophozoites. In purified homogeneous form the neutral thiol proteinase has a subunit molecular weight of about 56,000. +-. 4,000, a neutral pH optimum, and an isoelectric point of about 6. The purified neutral thiol proteinase of the present invention can be obtained by using anion exchange and chromatofocusing Fast Protein Liquid Chromatography (FPLC) to purify the major neutral proteinase from secretions of axenically cultured Entamoeba histolytica trophozoites. The homogeneous neutral thiol proteinase of the present invention is immunogenic. It is useful as a serodiagnostic reagent for identifying the presence of antibodies in the sera of individuals exposed to Entamoeba histolytica trophozoites. The purified homogeneous enzyme can be used in ELISA assays or in other standard immunoassays.

6194421, Feb 27, 2001

Dec 30, 1997

9/000801

Fred E. Cohen - San Francisco CA
James H. McKerrow - San Francisco CA
George L. Kenyon - San Francisco CA
Zhe Li - Malden MA
Xiaowu Chen - San Francisco CA
Baoqing Gong - San Francisco CA
Rongshi Li - San Francisco CA

The Regents of the University of California - Oakland CA

A61K 31404, A61K 3144, A61K 3147, A61K 31472, A61K 31502

514277

Compositions and methods are disclosed for treating a patient infected with a metazoan parasite by inhibiting the enzymatic action of the metazoan parasite protease, wherein there is employed at least one compound of formula I A--X--B wherein A is a substituted or unsubstituted heteroaromatic ring system comprising one to three rings which binds to at least one of the S2, S1 and S1' subsites; B is a substituted or unsubstituted homoaromatic ring system comprising one to three rings which binds to at least one of the S1', S1 and S2 subsites; and X is --C. dbd. C--C(. dbd. O)--. These compositions and methods have particular utility in the treatment of schistosomiasis, malaria and other infectious diseases.

5284829, Feb 8, 1994

Nov 26, 1991

7/798565

James H. McKerrow - San Francisco CA
Fred E. Cohen - San Francisco CA

The Regents of the University of California - Oakland CA

A61K 3710, A61K 3702

514 18

The invention relates to synthetic tetrapeptides that contain a peptide blocking group at the amino terminus and an enzyme inhibitor at the carboxy terminus, and their use in the prevention of schistosome parasite infection.

5610192, Mar 11, 1997

Mar 28, 1995

8/387760

Fred E. Cohen - San Francisco CA
James H. McKerrow - San Francisco CA
Christine S. Ring - San Francisco CA
Philip J. Rosenthal - Nicasio CA
George L. Kenyon - San Francisco CA
Zhe Li - San Francisco CA

The Regents of the University of California - Oakland CA

A61K 3115

514614

Compositions and methods for treating a patient infected with a metazoan parasite by inhibiting the enzymatic action of the metazoan parasite protease. The compositions comprise at least one metazoan protease inhibitor which binds to the S2 subsite and at least one of the S1 and S1' subsites of the metazoan parasite protease. The methods comprise administration to a patient infected with a metazoan parasite of at least one metazoan protease inhibitor in an amount effective to inhibit the protease of the metazoan parasite, thereby killing the parasite.

5739170, Apr 14, 1998

Mar 30, 1995

8/413337

Fred E. Cohen - San Francisco CA
James H. McKerrow - San Francisco CA
George L. Kenyon - San Francisco CA
Zhe Li - Malden MA
Xiaowu Chen - San Francisco CA
Baoqing Gong - San Francisco CA
Rongshi Li - San Diego CA

The Regents of the University of California - Oakland CA

A61K 3112, A61K 31135

514685

Compositions and methods are disclosed for treating a patient infected with a metazoan parasite by inhibiting the enzymatic action of the metazoan parasite protease, wherein there is employed at least one compound of formula I A--X--B wherein A is a substituted or unsubstituted homoaromatic ring system comprising one to three rings which bind to at least one of the S2, S1 and S1' subsites; B is a substituted or unsubstituted homoaromatic ring system comprising one to three rings which bind to at least one of the S1', S1 and S2 subsites; and X is --C. dbd. C--C(. dbd. O)--. These compositions and methods have particular utility in the treatment of schistosomiasis, malaria, and other infectious diseases.

6838443, Jan 4, 2005

Nov 26, 2003

10/723672

Robert H. Cichewicz - Santa Cruz CA, US
Muraleedharan G. Nair - Okemos MI, US
James H. McKerrow - San Francisco CA, US

Board of Trustees of Michigan State University - East Lansing MI
The Regents of the University of California - Oakland CA
The United States of America as represented by the Department of Veterans Affairs - Washington DC

A01N 4304, A61K 3170, A61K 31545, A61K 3152

514 33, 514510, 514548, 552208, 552261, 552262, 552265, 552266, 552267

Anthraquinones are described which are antihelminthic and in particular, are useful in compositions for inhibiting sp. in vitro or in vivo. The preferred anthraquinones have the formula: wherein R, R, R, and Rare each hydrogen, hydroxy, halogen, alkyl, substituted alkyl, alkene, substituted alkene, alkyne, aryl, substituted aryl, cyclic, substituted cyclic, acid group, carbohydrate, or combination thereof, R is a group containing 1 to 12 carbons such as methyl, alkyl, substituted alkyl, aldehyde, hydroxy, hydroxymethyl, acid group, carbohydrate, or combination thereof, and the halogen is I, F, Br, or Cl.