DR. JAMES H MCKERROW, MD
Medical Practice at Parnassus Ave, San Francisco, CA

License number
California G35727
Category
Medical Practice
Type
Anatomic Pathology
Address
Address
350 Parnassus Ave, San Francisco, CA 94143
Phone
(415) 476-2960
(415) 502-8193 (Fax)
(415) 476-4029
(415) 476-4150 (Fax)

Personal information

See more information about JAMES H MCKERROW at radaris.com
Name
Address
Phone
James Hobson Mckerrow, age 76
29133 Willow Creek Rd, Occidental, CA 95465
(707) 865-9834
James Hobson Mckerrow, age 76
1512 Willard St, San Francisco, CA 94117
(415) 564-2393
(707) 865-9834
James Hobson Mckerrow, age 76
29133 Willow Creek Rd, Jenner, CA 95450
(707) 865-9834
James H Mckerrow
29133 Willow Creek, Monte Rio, CA 95462
(707) 865-9834
James Hobson Mckerrow, age 76
10264 Meadowview Dr, San Diego, CA 92131
(415) 564-2393

Professional information

James H Mckerrow Photo 1

Dr. James H Mckerrow, San Francisco CA - MD (Doctor of Medicine)

Specialties:
Anatomic Pathology
Address:
UCSF Research Laboratory
1700 4Th St SUITE 508B, San Francisco 94158
(415) 514-3162 (Phone)
Certifications:
Anatomic Pathology, 1980
Awards:
Healthgrades Honor Roll
Languages:
English
Hospitals:
UCSF Research Laboratory
1700 4Th St SUITE 508B, San Francisco 94158
UCSF Medical Center
505 Parnassus Ave, San Francisco 94143
UCSF Medical Center at Mount Zion
1600 Divisadero St, San Francisco 94115
Education:
Medical School
State University of New York / Health Science Center At Stony Brook
Graduated: 1976
Stony Brook University Hospital S U N Y Health Sciences Center
University Of California-San Francisco


James Mckerrow Photo 2

Director, Sandler Center At Mission Bay At Ucsf

Location:
San Francisco Bay Area
Industry:
Pharmaceuticals


James Mckerrow Photo 3

Inhibitors Of Metazoan Parasite Proteases

US Patent:
6548521, Apr 15, 2003
Filed:
Jul 28, 2000
Appl. No.:
09/628080
Inventors:
Fred Ehrenkranz Cohen - San Francisco CA
James Hobson McKerrow - San Francisco CA
Christine Sun Ring - San Francisco CA
Philip Jon Rosenthal - Nicasio CA
George Lommel Kenyon - San Francisco CA
Zhe Li - San Francisco CA
Assignee:
The Regents of the University of California - Oakland CA
International Classification:
A61K 31404
US Classification:
514354, 514248, 514307, 514311, 514399, 514355, 514419, 514457
Abstract:
Compositions and methods for treating a patient infected with a metazoan parasite by inhibiting the enzymatic action of the metazoan parasite protease, wherein there is employed at least one compound of formula I wherein A is a substituted or unsubstituted homoaromatic or heteroaromatic ring system comprising one to three rings which binds to at least one of the S2, S1 and S1′ subsites; B is a substituted or unsubstituted homoaromatic or heteroaromatic ring system comprising one to three rings which binds to at least one of the S1′, S1 and S2 subsites; and X is —C C—C( O)—. These compositions and methods have particular utility in the treatment of schistosomiasis, malaria, and other infectious diseases.


James Mckerrow Photo 4

Antihelminthic Anthraquinones And Method Of Use Thereof

US Patent:
6800615, Oct 5, 2004
Filed:
Dec 12, 2002
Appl. No.:
10/317906
Inventors:
Robert H. Cichewicz - Santa Cruz CA
Muraleedharan G. Nair - Okemos MI
James H. McKerrow - San Francisco CA
Assignee:
Board of Trustees of Michigan State University - East Lansing MI
The Regent of the University of California - Oakland CA
The United States of America as represented by the Department of Veterans Affairs - Washington DC
International Classification:
A01K 4304
US Classification:
514 33, 514510, 514548, 552208, 552261, 552262, 552265, 552266, 552267
Abstract:
Anthraquinones are described which are antihelminthic and in particular, are useful in compositions for inhibiting Schistosoma sp. in vitro or in vivo. The preferred anthraquinones have the formula: wherein R , R , R , and R are each hydrogen, hydroxy, halogen, alkyl, substituted alkyl, alkene, substituted alkene, alkyne, aryl, substituted aryl, cyclic, substituted cyclic, acid group, carbohydrate, or combination thereof, R is a group containing 1 to 12 carbons such as methyl, alkyl, substituted alkyl, aldehyde, hydroxy, hydroxymethyl, acid group, carbohydrate, or combination thereof, and the halogen is I, F, Br, or Cl.


James Mckerrow Photo 5

Serodiagnostic Reagent For Entamoeba Histolytica

US Patent:
4762789, Aug 9, 1988
Filed:
Jan 16, 1986
Appl. No.:
6/819892
Inventors:
William E. Keene - Berkeley CA
James H. McKerrow - San Francisco CA
Assignee:
The University of California - Berkeley CA
International Classification:
C12N 950, C12N 1500, C12Q 100, G01N 3354
US Classification:
435219
Abstract:
The present invention is a composition of matter composed essentially of a purified homogeneous thiol proteinase secreted by Entamoeba histolytica trophozoites. In purified homogeneous form the neutral thiol proteinase has a subunit molecular weight of about 56,000. +-. 4,000, a neutral pH optimum, and an isoelectric point of about 6. The purified neutral thiol proteinase of the present invention can be obtained by using anion exchange and chromatofocusing Fast Protein Liquid Chromatography (FPLC) to purify the major neutral proteinase from secretions of axenically cultured Entamoeba histolytica trophozoites. The homogeneous neutral thiol proteinase of the present invention is immunogenic. It is useful as a serodiagnostic reagent for identifying the presence of antibodies in the sera of individuals exposed to Entamoeba histolytica trophozoites. The purified homogeneous enzyme can be used in ELISA assays or in other standard immunoassays.


James Mckerrow Photo 6

Inhibitors Of Metazoan Parasite Proteases

US Patent:
6194421, Feb 27, 2001
Filed:
Dec 30, 1997
Appl. No.:
9/000801
Inventors:
Fred E. Cohen - San Francisco CA
James H. McKerrow - San Francisco CA
George L. Kenyon - San Francisco CA
Zhe Li - Malden MA
Xiaowu Chen - San Francisco CA
Baoqing Gong - San Francisco CA
Rongshi Li - San Francisco CA
Assignee:
The Regents of the University of California - Oakland CA
International Classification:
A61K 31404, A61K 3144, A61K 3147, A61K 31472, A61K 31502
US Classification:
514277
Abstract:
Compositions and methods are disclosed for treating a patient infected with a metazoan parasite by inhibiting the enzymatic action of the metazoan parasite protease, wherein there is employed at least one compound of formula I A--X--B wherein A is a substituted or unsubstituted heteroaromatic ring system comprising one to three rings which binds to at least one of the S2, S1 and S1' subsites; B is a substituted or unsubstituted homoaromatic ring system comprising one to three rings which binds to at least one of the S1', S1 and S2 subsites; and X is --C. dbd. C--C(. dbd. O)--. These compositions and methods have particular utility in the treatment of schistosomiasis, malaria and other infectious diseases.


James Mckerrow Photo 7

Synthetic Tetrapeptides For The Prevention Of Schistosome Parasite Infection

US Patent:
5284829, Feb 8, 1994
Filed:
Nov 26, 1991
Appl. No.:
7/798565
Inventors:
James H. McKerrow - San Francisco CA
Fred E. Cohen - San Francisco CA
Assignee:
The Regents of the University of California - Oakland CA
International Classification:
A61K 3710, A61K 3702
US Classification:
514 18
Abstract:
The invention relates to synthetic tetrapeptides that contain a peptide blocking group at the amino terminus and an enzyme inhibitor at the carboxy terminus, and their use in the prevention of schistosome parasite infection.


James Mckerrow Photo 8

Inhibitors Of Metazoan Parasite Proteases

US Patent:
5610192, Mar 11, 1997
Filed:
Mar 28, 1995
Appl. No.:
8/387760
Inventors:
Fred E. Cohen - San Francisco CA
James H. McKerrow - San Francisco CA
Christine S. Ring - San Francisco CA
Philip J. Rosenthal - Nicasio CA
George L. Kenyon - San Francisco CA
Zhe Li - San Francisco CA
Assignee:
The Regents of the University of California - Oakland CA
International Classification:
A61K 3115
US Classification:
514614
Abstract:
Compositions and methods for treating a patient infected with a metazoan parasite by inhibiting the enzymatic action of the metazoan parasite protease. The compositions comprise at least one metazoan protease inhibitor which binds to the S2 subsite and at least one of the S1 and S1' subsites of the metazoan parasite protease. The methods comprise administration to a patient infected with a metazoan parasite of at least one metazoan protease inhibitor in an amount effective to inhibit the protease of the metazoan parasite, thereby killing the parasite.


James Mckerrow Photo 9

Inhibitors Of Metazoan Parasite Proteases

US Patent:
5739170, Apr 14, 1998
Filed:
Mar 30, 1995
Appl. No.:
8/413337
Inventors:
Fred E. Cohen - San Francisco CA
James H. McKerrow - San Francisco CA
George L. Kenyon - San Francisco CA
Zhe Li - Malden MA
Xiaowu Chen - San Francisco CA
Baoqing Gong - San Francisco CA
Rongshi Li - San Diego CA
Assignee:
The Regents of the University of California - Oakland CA
International Classification:
A61K 3112, A61K 31135
US Classification:
514685
Abstract:
Compositions and methods are disclosed for treating a patient infected with a metazoan parasite by inhibiting the enzymatic action of the metazoan parasite protease, wherein there is employed at least one compound of formula I A--X--B wherein A is a substituted or unsubstituted homoaromatic ring system comprising one to three rings which bind to at least one of the S2, S1 and S1' subsites; B is a substituted or unsubstituted homoaromatic ring system comprising one to three rings which bind to at least one of the S1', S1 and S2 subsites; and X is --C. dbd. C--C(. dbd. O)--. These compositions and methods have particular utility in the treatment of schistosomiasis, malaria, and other infectious diseases.


James Mckerrow Photo 10

Antihelminthic Anthraquinones And Method Of Use Thereof

US Patent:
6838443, Jan 4, 2005
Filed:
Nov 26, 2003
Appl. No.:
10/723672
Inventors:
Robert H. Cichewicz - Santa Cruz CA, US
Muraleedharan G. Nair - Okemos MI, US
James H. McKerrow - San Francisco CA, US
Assignee:
Board of Trustees of Michigan State University - East Lansing MI
The Regents of the University of California - Oakland CA
The United States of America as represented by the Department of Veterans Affairs - Washington DC
International Classification:
A01N 4304, A61K 3170, A61K 31545, A61K 3152
US Classification:
514 33, 514510, 514548, 552208, 552261, 552262, 552265, 552266, 552267
Abstract:
Anthraquinones are described which are antihelminthic and in particular, are useful in compositions for inhibiting sp. in vitro or in vivo. The preferred anthraquinones have the formula: wherein R, R, R, and Rare each hydrogen, hydroxy, halogen, alkyl, substituted alkyl, alkene, substituted alkene, alkyne, aryl, substituted aryl, cyclic, substituted cyclic, acid group, carbohydrate, or combination thereof, R is a group containing 1 to 12 carbons such as methyl, alkyl, substituted alkyl, aldehyde, hydroxy, hydroxymethyl, acid group, carbohydrate, or combination thereof, and the halogen is I, F, Br, or Cl.