Inventors:
Robert H. Cichewicz - Santa Cruz CA
Muraleedharan G. Nair - Okemos MI
James H. McKerrow - San Francisco CA
Assignee:
Board of Trustees of Michigan State University - East Lansing MI
The Regent of the University of California - Oakland CA
The United States of America as represented by the Department of Veterans Affairs - Washington DC
International Classification:
A01K 4304
US Classification:
514 33, 514510, 514548, 552208, 552261, 552262, 552265, 552266, 552267
Abstract:
Anthraquinones are described which are antihelminthic and in particular, are useful in compositions for inhibiting Schistosoma sp. in vitro or in vivo. The preferred anthraquinones have the formula: wherein R , R , R , and R are each hydrogen, hydroxy, halogen, alkyl, substituted alkyl, alkene, substituted alkene, alkyne, aryl, substituted aryl, cyclic, substituted cyclic, acid group, carbohydrate, or combination thereof, R is a group containing 1 to 12 carbons such as methyl, alkyl, substituted alkyl, aldehyde, hydroxy, hydroxymethyl, acid group, carbohydrate, or combination thereof, and the halogen is I, F, Br, or Cl.