JAMES GORDON HECKER
Medical Practice in Delaware
License number
Pennsylvania MD046376L
Category
Medicine
Type
Medical Physician and Surgeon
Address
Address
2
Delaware
Media, PA 19063
Media, PA 19063
Personal information
See more information about JAMES GORDON HECKER at radaris.comName
Address
Phone
814 Annie St, Johnstown, PA 15902
PO Box 180, New Florence, PA 15944
102 Lafree St, Johnstown, PA 15904
309 Eagle Point Blvd, Erie, PA 16511
4025 Bradford Cir, Mount Joy, PA 17552
Professional information
Elevation Of Induced Heat Shock Proteins In Patient's Cerebral Spinal Fluid: A Biomarker Of Risk/Onset Of Ischemia And/Or Paralysis In Aortic Surgery
US Patent:
2011011, May 12, 2011
Filed:
Oct 7, 2010
Appl. No.:
12/899833
Inventors:
James G. Hecker - Media PA, US
Michael Lee McGarvey - Philadelphia PA, US
Michael Lee McGarvey - Philadelphia PA, US
International Classification:
G01N 33/53, G01N 33/566, C07K 14/47
US Classification:
435 792, 436501, 530350
Abstract:
Provided are methods for intra-operatively predicting, detecting or diagnosing the risk or onset of spinal cord ischemia and/or associated permanent paralysis in a patient, based upon the stress-induced elevation of levels of heat shock proteins, specifically HSP70 and/or HSP27 in the cerebral spinal fluid of the patient, as measured during thoracic-aorta surgery, particularly thoracic aneurysm repair surgery, that will permit intra-operative medical intervention to try to prevent or attenuate severe, and often fatal, complications. Further provided are kits, assay devices and methods of analyzing biomarker data for use in pre-, intra- or post-operatively detecting the stress-induced elevations of the measured levels of HSP70 and/or HSP27, and the biomarker itself.
Novel Methods And Models For Rapid, Widespread Delivery Of Genetic Material To The Cns Using Non-Viral, Cationic Lipid-Mediated Vectors
US Patent:
2010024, Sep 30, 2010
Filed:
Dec 14, 2006
Appl. No.:
12/086605
Inventors:
James G Hecker - Media PA, US
Micheal Nantz - Louisville KY, US
Micheal Nantz - Louisville KY, US
International Classification:
A61K 31/7088, A61P 25/28, A61P 25/16, A61P 25/00, C12N 15/64, C12N 5/02
US Classification:
514 44 A, 514 44 R, 4353201, 435375
Abstract:
Provided are safe, non-invasive, non-viral delivery methods for providing a nucleic acid into the neuronal and non-neuronal cells of the central nervous system (CNS) of a subject to protect neuronal and non-neuronal cells from ischemic or traumatic injury, wherein the nucleic acid encodes a therapeutic proteins, specifically providing rapid transient expression and widespread distribution for in vitro or in vivo applications. Further provided are methods for the intrathecal delivery to the cerebrospinal fluid (CSF) of a neuroprotective gene sequence, e.g., a heat shock protein (HSP), complexed with cationic lipid compositions to achieve such delivery, and the complexes used therein.