Inventors:
James D. Ross - San Antonio TX, US
William R. Law - Wayne PA, US
Assignee:
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS - URBANA IL
International Classification:
A61K 31/7064, A61K 31/519, A61P 9/00
Abstract:
Provided are compositions and methods for the treatment of myocardial dysfunction associated with SIRS or sepsis, which methods comprise the administration to a patient in need thereof of a composition comprising one or more adenosine deaminase (ADA) inhibitor and/or one or more xanthine oxidase (XO) inhibitor. Exemplified herein are methods for the treatment of myocardial dysfunction, which methods comprise the administration of a composition comprising the ADA inhibitor pentostatin and/or a composition comprising the XO inhibitor allopurinol. Advantageously, the methods disclosed herein that employ the administration of one or more ADA inhibitor(s) do not significantly affect cardiac TNF-α mRNA expression and/or protein levels.