Inventors:
James E. Manning - Chapel Hill NC
Assignee:
The University of North Carolina at Chapel Hill - Chapel Hill NC
International Classification:
A01N 3114, A01N 3318, A01N 2500
Abstract:
A method of treating a subject in cardiac arrest, comprises blocking the descending aorta of the subject and then perfusing the aortic arch of the subject with a protective solution. The protective solution is one capable of delivering oxygen to the heart of said subject, such as a perfluorochemical blood substitute. Following perfusion, spontaneous circulation is restored.
In an improved embodiment of the foregoing, a vasoconstrictor such as epinephrine is administered concurrently with the perfusing step in an amount effective to enhance coronary perfusion with said protective solution.