James D Crapo
Physician at Frst St, Englewood, CO
License number
Colorado 36479
Issued Date
Sep 11, 1997
Renew Date
May 1, 2015
Expiration Date
Apr 30, 2017
Type
Physician
Address
Address
4650 S Forest St, Englewood, CO 80113
Personal information
See more information about James D Crapo at radaris.comName
Address
Phone
4650 S Forest St, Englewood, CO 80113
3701 Clarkson St, Englewood, CO 80110
4650 Forest St, Cherry Hills Village, CO 80110
5277 Geneva St, Englewood, CO 80111
4650 S Forest St, Englewood, CO 80113
Professional information
See more information about James D Crapo at trustoria.com
Substituted Porphyrins
Substituted Porphyrins
US Patent:
6544975, Apr 8, 2003
Filed:
Jan 25, 2000
Appl. No.:
09/490537
Inventors:
James D. Crapo - Englewood CO
Brian J. Day - Englewood CO
Michael P. Trova - Schenectady NY
Polivina Jolicia F. Gauuan - Albany NY
Douglas B. Kitchen - Schenectady NY
Irwin Fridovich - Durham NC
Ines Batinic-Haberle - Durham NC
Brian J. Day - Englewood CO
Michael P. Trova - Schenectady NY
Polivina Jolicia F. Gauuan - Albany NY
Douglas B. Kitchen - Schenectady NY
Irwin Fridovich - Durham NC
Ines Batinic-Haberle - Durham NC
Assignee:
National Jewish Medical and Research Center - Denver CO
Aeolus Pharmaceuticals INC - Research Triangle Park NC
Duke University - Durham NC
Aeolus Pharmaceuticals INC - Research Triangle Park NC
Duke University - Durham NC
International Classification:
A61K 31409
US Classification:
514185, 514365, 514383, 514397, 514406, 514410, 540145
Abstract:
The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.
Substituted Porphyrins
Substituted Porphyrins
US Patent:
6479477, Nov 12, 2002
Filed:
Apr 23, 1999
Appl. No.:
09/296615
Inventors:
James D. Crapo - Englewood CO
Brian J. Day - Englewood CO
Polivina Jolicia F. Gauuan - Albany NY
Michael P. Trova - Schenectady NY
Brian J. Day - Englewood CO
Polivina Jolicia F. Gauuan - Albany NY
Michael P. Trova - Schenectady NY
Assignee:
Duke University - Durham NC
Aeolus Pharmaceuticals, Inc. - Research Triangle Park NC
Aeolus Pharmaceuticals, Inc. - Research Triangle Park NC
International Classification:
A61K 5104
US Classification:
514183, 514410, 540145
Abstract:
The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods. Compounds of the invention include those of Formula I.
Methods For Identifying Compounds As Antioxidants
Methods For Identifying Compounds As Antioxidants
US Patent:
6900026, May 31, 2005
Filed:
Nov 9, 2001
Appl. No.:
10/039869
Inventors:
Douglas C. Wallace - Atlanta GA, US
Simon Melov - Atlanta GA, US
James D. Crapo - Cherry Hills Village CO, US
Brian J. Day - Englewood CO, US
Simon Melov - Atlanta GA, US
James D. Crapo - Cherry Hills Village CO, US
Brian J. Day - Englewood CO, US
Assignee:
Duke University - Durham NC
Emory University - Atlanta GA
Emory University - Atlanta GA
International Classification:
C12Q001/34
US Classification:
435 18, 424 92
Abstract:
The present application describes methods for the testing of compounds of potential usefulness as therapeutic antioxidants and/or as therapeutic free radical scavengers. The animal model for testing such compounds is the Sod2CJE homozygous Manganese Superoxide Dismutase-deficient mouse. When pups of these mice are treated with certain antioxidants, they survive past about 7 days of age, and later develop characteristic histological changes and characteristic neurobehavioral disorders. Those treated mice can be further treated with test compounds which may or may not cross the blood brain barrier, and the life span and physical and neurobehavioral characteristics of those mice provide information about the potential utility of the test compound as a therapeutic antioxidant. Phenotypes of the treated mice allow conclusions regarding targeted areas of the brain and thus, applications to particular disorders such as Parkinsonism.
Substituted Porphyrins
Substituted Porphyrins
US Patent:
7189707, Mar 13, 2007
Filed:
Jan 23, 2003
Appl. No.:
10/349171
Inventors:
James D. Crapo - Englewood CO, US
Brian J. Day - Englewood CO, US
Michael P. Trova - Schenectady NY, US
Polivina Jolicia F. Gauuan - Albany NY, US
Douglas B. Kitchen - Schenectady NY, US
Irwin Fridovich - Durham NC, US
Ines Batinic-Haberle - Durham NC, US
Brian J. Day - Englewood CO, US
Michael P. Trova - Schenectady NY, US
Polivina Jolicia F. Gauuan - Albany NY, US
Douglas B. Kitchen - Schenectady NY, US
Irwin Fridovich - Durham NC, US
Ines Batinic-Haberle - Durham NC, US
Assignee:
National Jewish Medical Research Center - Denver CO
Duke University - Durham NC
Aeolus Sciences, Inc. - Laguna Niguel CA
Duke University - Durham NC
Aeolus Sciences, Inc. - Laguna Niguel CA
International Classification:
A61K 31/409
US Classification:
514185, 514365, 514383, 514397, 514406, 514410
Abstract:
The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.
Substituted Porphyrins
Substituted Porphyrins
US Patent:
6916799, Jul 12, 2005
Filed:
Jun 14, 2001
Appl. No.:
09/880125
Inventors:
Irwin Fridovich - Durham NC, US
Ines Batinic-Haberle - Durham NC, US
James D. Crapo - Englewood CO, US
Brian J. Day - Englewood CO, US
Ines Batinic-Haberle - Durham NC, US
James D. Crapo - Englewood CO, US
Brian J. Day - Englewood CO, US
Assignee:
Duke University - Durham NC
National Jewish Medical and Research Center - Denver CO
National Jewish Medical and Research Center - Denver CO
International Classification:
C07D487/22, A61K031/409, A61K031/555, A61P011/06
US Classification:
514183, 514184, 514185, 540145
Abstract:
The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.
Substituted Porphyrins
Substituted Porphyrins
US Patent:
2008011, May 15, 2008
Filed:
Jan 17, 2008
Appl. No.:
12/016157
Inventors:
Irwin Fridovich - Durham NC, US
Ines Batinic-Haberle - Durham NC, US
James Crapo - Englewood CO, US
Brian Day - Englewood CO, US
Ines Batinic-Haberle - Durham NC, US
James Crapo - Englewood CO, US
Brian Day - Englewood CO, US
International Classification:
A61K 31/555, C07D 487/22, A61K 31/444
US Classification:
514185000, 514332000, 540145000
Abstract:
The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.
Substituted Porphyrins
Substituted Porphyrins
US Patent:
8546562, Oct 1, 2013
Filed:
Apr 26, 2012
Appl. No.:
13/457232
Inventors:
James D. Crapo - Englewood CO, US
Brian J. Day - Englewood CO, US
Michael P. Trova - Schenectady NY, US
Douglas B. Kitchen - Schenectady NY, US
Irwin Fridovich - Durham NC, US
Ines Batinic-Haberle - Durham NC, US
Brian J. Day - Englewood CO, US
Michael P. Trova - Schenectady NY, US
Douglas B. Kitchen - Schenectady NY, US
Irwin Fridovich - Durham NC, US
Ines Batinic-Haberle - Durham NC, US
International Classification:
C07D 487/22, A01N 55/02
US Classification:
540145, 514185, 514410
Abstract:
The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.
Tetrapyrroles
Tetrapyrroles
US Patent:
2004003, Feb 26, 2004
Filed:
Apr 28, 2003
Appl. No.:
10/424150
Inventors:
Irwin Fridovich - Durham NC, US
Ines Batinic-Haberle - Durham NC, US
Ivan Spasojevic - Durham NC, US
James Crapo - Englewood CO, US
Brian Day - Englewood CO, US
Ines Batinic-Haberle - Durham NC, US
Ivan Spasojevic - Durham NC, US
James Crapo - Englewood CO, US
Brian Day - Englewood CO, US
Assignee:
DUKE UNIVERSITY AND NATIONAL JEWISH MEDICAL AND RESEARCH CENTER
International Classification:
C 07D 4 3/14, C07H017/02
US Classification:
548/518000, 536/017400
Abstract:
The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.
Tetrapyrroles
Tetrapyrroles
US Patent:
2003006, Apr 10, 2003
Filed:
Jun 14, 2001
Appl. No.:
09/880075
Inventors:
Irwin Fridovich - Durham NC, US
Ines Batinic-Haberle - Durham NC, US
Ivan Spasojevic - Durham NC, US
James Crapo - Englewood CO, US
Brian Day - Englewood CO, US
Ines Batinic-Haberle - Durham NC, US
Ivan Spasojevic - Durham NC, US
James Crapo - Englewood CO, US
Brian Day - Englewood CO, US
International Classification:
A61K031/4439, C 07D 4 3/14
US Classification:
514/340000, 514/422000, 540/145000, 548/518000
Abstract:
The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.
Cancer Therapy
Cancer Therapy
US Patent:
2003005, Mar 13, 2003
Filed:
Jan 22, 2002
Appl. No.:
10/051367
Inventors:
James Crapo - Englewood CO, US
Brian Day - Englewood CO, US
Ines Batinic-Haberle - Durham NC, US
Richard Gammans - Research Triangle Park NC, US
Zeljko Vujaskovic - Durham NC, US
Brian Day - Englewood CO, US
Ines Batinic-Haberle - Durham NC, US
Richard Gammans - Research Triangle Park NC, US
Zeljko Vujaskovic - Durham NC, US
International Classification:
A61K031/555
US Classification:
514/185000, 514/410000
Abstract:
The present invention relates, in general, to cancer therapy, and, in particular, to a method of preventing or treating cancer using low molecular weight antioxidants (e.g., mimetics of superoxide dismutase (SOD)) as the active agent or as a chemo- and/or radio-protectant. The invention also relates to compounds and compositions suitable for use in such a method.