Inventors:
James A Hendrix - Hillsborough NJ, US
Horst Hemmerle - Bad Soden, DE
Matthias Urmann - Eschborn DE, US
Gregory M Shutske - Pittstown NJ, US
Jospeh T Strupczewski - Flemington NJ, US
Kenneth J Bordeau - Kintnersville PA, US
John G Jurcak - Bethlehem PA, US
Thaddeus Nieduzak - Bridgewater NJ, US
Sharon A Jackson - Whitehouse Station NJ, US
Paul Angell - Liberty Township OH, US
James P Carey - Cincinnati OH, US
George Lee - Somerville NJ, US
David Fink - Lebanon NJ, US
Jean-Fancois Sabuco - Paris, FR
Yulin Chiang - Convent Station NJ, US
Nicola Collar - Madison NJ, US
Assignee:
Aventis Pharmaceuticals Inc. - Bridgewater NJ
International Classification:
A61K 31/496, C07D 409/04, C07D 409/14, A61K 31/4535, A61K 31/454, C07D 403/04
US Classification:
51425213, 51425404, 51425406, 51425409, 544368, 544370, 544371, 544373, 544376, 544121, 544360, 544361, 544362, 544131, 544295, 546187, 546193, 546194, 546198
Abstract:
The invention relates to heterocyclic substituted carbonyl derivatives that display selective binding to dopamine Dreceptors. In another aspect, the invention relates to a method for treating central nervous system disorders associated with the dopamine Dreceptor activity in a patient in need of such treatment comprising administering to the subject a therapeutically effective amount of said compounds for alleviation of such disorder. The central nervous system disorders that may be treated with these compounds include Psychotic Disorders, Substance Dependence, Substance Abuse, Dyskinetic Disorders (e. g. Parkinson's Disease, Parkinsonism, Neuroleptic-Induced Tardive Dyskinesia, Gilles de la Tourette Syndrome and Huntington's Disease), Dementia, Anxiety Disorders, Sleep Disorders, Circadian Rhythm Disorders and Mood Disorders. The subject invention is also directed towards processes for the preparation of the compounds described herein as well as methods for making and using the compounds as imaging agents for dopamine Dreceptors.