Inventors:
Phillip I. Tarr - Seattle WA
Sima S. Bilge - Bellevue WA
Thomas E. Besser - Moscow ID
James C. Vary - Seattle WA
Assignee:
Children's Hospital and Medical Center - Seattle WA
University of Washington - Seattle WA
University Research Foundation - Pullman WA
International Classification:
A61K 3800, A61K 3902, A61K 39108, A61K 3900, C07C24500
Abstract:
Polypeptides encoded by a continuous segment of chromosomal DNA from E. coli O157:H7, isolated on plasmid pSC(overlap) (ATCC No. 69648), that encodes an adhesin (SEQ ID NO:5) that mediates bacterial colonization of bovine intestines, vaccines derived therefrom, and antibodies directed against the adhesin.