Inventors:
James Conrad Eisenach - Winston Salem NC, US
International Classification:
A61K 31/485, A61K 31/381, A61K 31/498, A61K 31/5513, A61K 31/4725, A61K 31/444, A61K 31/437, A61P 25/04
US Classification:
514220, 514443, 514282, 514249, 514309, 514334, 514292
Abstract:
The present invention provides synergistic combinations for the treatment of conditions associated with pain including acute pain, e.g., postoperative pain, chronic pain, inflammatory pain, neuropathic pain and pain associated with migraine. In particular, the present invention relates to the use of an allosteric adenosine Areceptor enhancer in conjunction with opioid analgesics or 2-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA)/kainate antagonists for alleviating pain, e.g., postoperative pain.