DR. JAMES CHRIS SACKELLARES, M.D.
Neurology at 91 Ter, Gainesville, FL

7263467, Aug 28, 2007

Sep 30, 2003

10/673329

James Chris Sackellares - Gainesville FL, US
Linda Dance - Gainesville FL, US
Panos M. Pardalos - Gainesville FL, US
Wanpracha A. Chaovalitwongse - Hillsborough NJ, US

University of Florida Research Foundation Inc. - Gainesville FL
Arizona Board of Regents - Tempe AZ

G06F 15/00

702183, 702190

Characterizing the behavior of a chaotic, multi-dimensional system is achieved by measuring each of a number of signals associated with the system, and generating therefrom, a spatio-temporal response based on each signal. Multiple dynamical profiles are then generated for each spatio-temporal response, where each of the multiple dynamical profiles correspond to a different one of multiple dynamical parameters. Over a period of time, a determination is made as to whether a certain level of dynamic entrainment and/or disentrainment exists between the dynamical profiles associated with a selected one or a selected combination of dynamical parameters. Seizure warnings and/or predictions are provided based on this determination.

7461045, Dec 2, 2008

Aug 18, 2004

10/920446

Wanpracha A. Chaovalitwongse - Hillsborough NJ, US
Panos M. Pardalos - Gainesville FL, US
James C. Sackellares - Gainesville FL, US

University of Florida Research Foundation, Inc. - Gainesville FL
Arizona Board of Regents - Scottsdale AZ

G06F 9/44, G06N 7/02, G06N 7/06

706 52

An exemplary method for analyzing behavior of a system includes receiving dynamical measurement data regarding the system, applying a quadratically constrained quadratic 0-1 problem to identify data among the received data, and storing the identified data. An exemplary seizure warning method includes continuously calculating STLvalues, identifying critical sites by applying a quadratically constrained quadratic 0-1 solution to data (e. g. STLprofiles) derived from pre-seizure onset and post-seizure onset EEG signals, monitoring a T-index curve of the identified critical sites, warning of an impending seizure, observing a seizure and then repeating the cycle by identifying critical sites using the new data, and then monitoring them.

7373199, May 13, 2008

Aug 27, 2003

10/648354

James Chris Sackellares - Gainesville FL, US
Linda Dance - Gainesville FL, US

University of Florida Research Foundation, Inc. - Gainesville FL
Arizona Board of Regents - Tempe AR

A61B 5/04

600544

Characterizing the behavior of a chaotic, multi-dimensional system is achieved by measuring each of a number of signals associated with the system, and generating therefrom, a spatio-temporal response based on each signal. Chaoticity profiles are then generated for each spatio-temporal response. Over a period of time, a determination is made as to whether a certain level of dynamic entrainment and/or disentrainment exists between the chaoticity profiles associated with one or more critical channel groups of a selected predictor, where a predictor represents a given number of critical channel groups “x”, a given number of channels per group “y”, and a total number of channels N. Characterizing the behavior of the system is based on this determination.

2010021, Sep 2, 2010

Apr 14, 2008

12/532637

Frank M. Skidmore - Gainesville FL, US
James C. Sackellares - Gainesville FL, US
Mark Davidson - Florahome FL, US
Bernard F. Whiting - Gainesville FL, US
Panos M. Pardalos - Gainesville FL, US

UNIVERSITY OF FLOARIDA RESEARCH FOUNDATION, INC. - Gainesville FL

G01R 33/02

324247

Devices disclosed according to various embodiments use one or more arrays of atomic magnetometers to detect biologically derived magnetic fields. The disclosed devices and methods relate to application of utilization of a magnetic sensor with unique properties requiring changes in design, allowing new functions, and requiring alternative analysis methodologies. Various embodiments are also directed to methods for obtaining and processing biological magnetic signals. These methods may take advantage of the unique spatial arrangement of the atomic magnetometers and the capacity sensors to he used in either a scalar or a vector mode. Various embodiments have advantages over current magnetometer arrays for the purpose of detecting biological magnetic fields. Such advantages may include, for example: smaller size, lower power consumption, no necessity for cryogenic cooling, potential wafer-level fabrication, and/or the potential of better localization biological signals. In addition, various embodiments may allow increased target or subject mobility.

2007025, Nov 8, 2007

Feb 28, 2005

10/588749

Richard Melker - Gainesville FL, US
James Sackellares - Gainesville FL, US
Mark Gold - Gainesville FL, US
Donn Dennis - Gainesville FL, US

A61K 9/51

424009100

Systems and methods for diagnosing and/or treating diseases as well as monitoring disease treatment. For diagnosis, the present invention uses nanoparticle-based assemblies, which comprise a nanoparticle; a surrogate marker; and a means for detecting a specific chemical entity. In certain embodiments, nanoparticle-based assemblies include a payload for simultaneous diagnosis and treatment of disease. In further embodiments, a therapeutic drug and therapeutic drug marker are administered to a patient to monitor disease treatment. Bodily fluid samples are analyzed using sensor technology to detect the presence of surrogate and/or therapeutic drug markers to provide an efficient and accurate means for diagnosing a disease and/or monitoring disease treatment.

2006028, Dec 21, 2006

Jan 26, 2006

11/339606

James Sackellares - Gainesville FL, US
Linda Dance - Gainesville FL, US
Panos Pardalos - Gainesville FL, US
Wanpracha Chaovalitwongse - Hillsborough NJ, US

A61B 5/04

600544000

Techniques for investigating dynamical behavior of complex systems for monitoring, diagnosing, and predicting future behavior and trends are presented. A method includes generating a multi-dimensional representation for each signal acquired from corresponding channels of a multi-dimensional system, and generating dynamical profiles for each channel in accordance with one of multiple dynamical metrics. The method includes calculating multiple first statistical measures for a group of the channels that reflect a level of interaction among the channel group associated with at least one of the metrics. The method includes calculating in an initialization period a second statistical measure for each of the first statistical measures that reflect the association of the first statistical measures with related occurrences under investigation. The method includes selecting in the initialization period at least one of the metrics based on the second statistical measures, and identifying the first statistical measures corresponding to the selected metrics to characterize dynamical behavior.

6304775, Oct 16, 2001

Sep 22, 1999

9/400982

James Chris Sackellares - Gainesville FL

A61B 504

600544

Impending seizure warning (ISW), seizure susceptibility period detection (SSPD), hours or days before an impending seizure, and time to impending seizure prediction (TISP) are provided by measuring each of a number of signals from different locations about a patient's brain, and generating therefrom, a spatio-temporal response based on these signals. Chaoticity profiles are then generated for each spatio-temporal response. Over a period of time, a determination is made as to whether a certain level of dynamic entrainment exists between the chaoticity profiles associated with the responses from a set of critical locations. If so, a seizure warning, an indication of seizure susceptibility and a prediction of a time of occurrence of an impending seizure may be issued.

2005005, Mar 10, 2005

Feb 26, 2004

10/788501

Richard Melker - Gainesville FL, US
James Sackellares - Gainesville FL, US
Mark Gold - Gainesville FL, US

A61B005/08, A61M037/00

600532000, 604019000

The present invention includes systems and methods for monitoring therapeutic drug concentration in blood by detecting markers, such as odors, upon exhalation by a patient after the drug is taken, wherein such markers result either directly from the drug itself or from an additive combined with the drug. In the case of olfactory markers, the invention preferably utilizes electronic sensor technology, such as the commercial devices referred to as “artificial” or “electronic” noses or tongues, to non-invasively monitor drug levels in blood. The invention further includes a reporting system capable of tracking drug concentrations in blood (remote or proximate locations) and providing the necessary alerts with regarding to ineffective or toxic drug dosages in a patient.