JAMES C LEE, MD
Osteopathic Medicine in Philadelphia, PA

6835394, Dec 28, 2004

Dec 14, 1999

09/460605

Dennis E. Discher - Philadelphia PA
Bohdana M. Discher - Philadelphia PA
James C-M. Lee - Philadelphia PA
Frank S. Bates - St. Louis Park MN
Daniel A. Hammer - Villanova PA

The Trustees of the University of Pennsylvania - Philadelphia PA

A61K 9127

424450, 424 121, 424 9321, 424 951, 424417, 424489, 424502, 4284022, 264 41, 264 43

The present invention provides biocompatible vesicles comprising semi-permeable, thin-walled encapsulating membranes which are formed in an aqueous solution, and which comprise one or more synthetic super-amphiphilic molecules. When at least one super-amphiphile molecule is a block copolymer, the resulting synthetic vesicle is termed a “polymersome. ” The synthetic, reactive nature of the amphiphilic composition enables extensive, covalent cross-linking of the membrane, while maintaining semi-permeability. Cross-linking of the polymer building-block components provides mechanical control and long-term stability to the vesicle, thereby also providing a means of controlling the encapsulation or release of materials from the vesicle by modifying the composition of the membrane. Thus, the encapsulating membranes of the present invention are particularly suited for the reliable, durable and controlled transport, delivery and storage of materials.

6318419, Nov 20, 2001

Mar 2, 2001

9/796887

James W. Lee - Philadelphia PA

B65B 104, B65B 304, B67C 302

141108

A collection system and method for various uses including the efficient collection of leaves. The system includes a specially designed chute element and an attachable draw-string type of plastic bag. The bag unit has plural perforations formed therein to provide for an equalization of air pressure and resultant ease of placement of collected items into the bag. The invention incorporates fluid mechanics principles related to air flow and air pressure equalization.

2011006, Mar 17, 2011

May 17, 2010

12/781048

Michael B. Sommer - Bagsvaerd, DK
Ole Nielsen - Valby, DK
Hans Petersen - Vanlose, DK
Haleh Ahmadian - Solrod Strand, DK
Henrik Pedersen - Bronshoj, DK
Peter Brosen - Herlev, DK
Fiona Geiser - Glen Mills PA, US
James Lee - Philadelphia PA, US
Geoffrey Cox - West Chester PA, US
Olivier Dapremont - Folsom CA, US
Christina Suteu - Illkirch, FR
Sebastian P. Assenza - Fort Salonga NY, US
Shankar Hariharan - Inwood NY, US
Usha Nair - Nashville TN, US

H. Lundbeck A/S - Valby-Copenhagen

C07D 307/87, C07C 215/32

549467, 564319

A novel method is provided for the manufacture of escitalopram. The method comprises chromatographic separation of the enantiomers of citalopram or an intermediate in the production of citalopram using a chiral stationary phase such as Chiralpak™ AD or Chiralcel™ OD. Novel chiral intermediates for the synthesis of Escitalopram made by said method are also provided.

2005006, Mar 24, 2005

Jul 12, 2002

10/483824

Michael Sommer - Bagsvaerd, DE
Ole Nielsen - Valby, DE
Hans Petersen - Vanlose, DE
Haleh Ahmadian - Solrod Strand, DE
Henrik Pedersen - Bronshoj, DE
Peter Brosen - Herlev, DE
Fiona Geiser - Glen Mills PA, US
James Lee - Philadelphia PA, US
Geoffrey Cox - West Chester PA, US
Olivier Dapremont - Folsom CA, US
Christina Suteu - Illkirch, FR
Sebastian Assenza - Fort Salonga NY, US
Shankar Hariharan - Smithtown NY, US
Usha Nair - Nashville TN, US

C07D307/87, A61K031/343

514469000, 549467000

A novel method is provided for the manufacture of escitalopram. The method comprises chromatographic separation of the enantiomers of citalopram or an intermediate in the production of citalopram using a chiral stationary phase such as Chiralpak™ or Chiralcel™ OD. Novel chiral intermediates for the synthesis of Escitalopram made by said method are also provided.