Inventors:
Glenn V. Cornett - Palo Alto CA, US
James Page - Laramie WY, US
Wayne A. Jones - Palo Alto CA, US
Karen Page - Laramie WY, US
Assignee:
Gilead Sciences, Inc. - Foster City CA
International Classification:
A61K 31/4985, A61K 31/4355, A61K 31/192, A61K 31/195, A61P 9/10, A61K 31/34, A61K 31/407, A61K 31/343
US Classification:
514249, 514302, 514571, 514410, 514469, 514470
Abstract:
Embodiments of the present invention are related to novel therapeutic drugs, drug combinations, and associated methods for treating or preventing pulmonary disease, including pulmonary hypertension, pulmonary fibrosis, asthma and COPD, and heart failure, together with other pulmonary and cardiovascular diseases and their complications. More particularly, aspects of the present invention are related to the use of cicletanine and ruboxistaurin as monotherapies or in combination with other agents for treatment of disease. Cicletanine may be used as pure (+) or (−) enantiomers or as a racemic or non-racemic mixture of those enantiomers.