Inventors:
Prasun Chakravarty - Edison NJ, US
Michael Fisher - Ringoes NJ, US
Brenda Palucki - Hillsborough NJ, US
Min Park - Whippany NJ, US
William Parsons - Belle Mead NJ, US
Bishan Zhou - Hoboken NJ, US
James Carey - Downingtown PA, US
Douglas Frantz - Downingtown PA, US
Michael Kress - Exton PA, US
Damian Weaver - Lansdale PA, US
International Classification:
C07D 417/02, C07D 403/02, C07D 413/02
US Classification:
544132000, 544405000, 544366000, 546272400, 544333000, 546210000, 548200000, 548131000, 548215000, 548266200
Abstract:
Biaryl substituted triazole compounds represented by Formula I, II or III, or pharmaceutically acceptable salts thereof, and a process for making such compounds and salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier. Methods of treating conditions associated with, or caused by, sodium channel activity, including, for example, acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain, epilepsy, irritable bowel syndrome, depression, anxiety, multiple sclerosis, and bipolar disorder, comprise administering an effective amount of the present compounds, either alone, or in combination with one or more other therapeutically active compounds. A method of administering local anesthesia comprises administering an effective amount of a compound of the instant invention, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier.