DR. JAMES ARTHUR WILL, DVM
Medical Practice in Madison, WI

4918061, Apr 17, 1990

Jun 8, 1988

7/206994

Christian R. H. Raetz - Middleton WI
Richard A. Proctor - Madison WI
James A. Will - Columbus WI

Wisconsin Alumni Research Foundation - Madison WI

A61K 3170

514 62

A method of treating animals to protect them from the toxic effects of gram-negative endotoxin comprises administering to said animals a safe and effective amount of a compound having lipid X activity.

2009003, Feb 5, 2009

Feb 25, 2008

12/072208

John G. Webster - Madison WI, US
Dieter Haemmerich - Charleston SC, US
James Arthur Will - Columbus WI, US
David Mahvi - Middleton WI, US
Ann O'Rourke - Madison WI, US
David James Schutt - Charleston SC, US

A61B 18/18

606 33

An electrode array supports multiple electrodes and energizes them so that adjacent electrodes do not have the same polarity. In one embodiment, the electrodes are held about a circumference outside and surrounding a tumor and opposed electrodes are energized in a round robin fashion to promote current flow through the center of the tumor from a variety of angles.

5645849, Jul 8, 1997

Jun 7, 1995

8/487659

Thaddeus P. Pruss - Baltimore MD
James A. Will - Columbus WI

Clarion Pharmaceuticals, Inc. - Madison WI

A61K 970

424426

A fibrogen-free substrate having as a hemostatic agent on a surface thereof a mixture of a clot-promoting amount of thrombin and an amount of epsilon aminocaproic acid (EACA) effective to accelerate the rate of blood clotting induced by the thrombin is useful as a hemostatic patch which is safe, inexpensive and which rapidly controls bleeding from a wound. A patch which rapidly stanches the flow of blood from a lesion on a parenchymal organ by pressing it against the surface of the organ for 3-5 minutes, is produced by applying thrombin, EACA and CaCl. sub. 2 to a rigid sheet of biodegradable foam, such as an absorbable gelatin sponge, and compressing the dry sheet to produce a flexible sheet which conforms to the contour of the organ without the necessity of pre-moistening. The EACA raises the pH of the acidic fluid associated with the wound and thereby accelerates the activation of the thrombin.

5643596, Jul 1, 1997

Jun 7, 1995

8/474127

Thaddeus P. Pruss - Baltimore MD
James A. Will - Columbus WI

Clarion Pharmaceuticals, Inc. - Madison WI

A61K 970

424426

A fibrogen-free substrate having as a hemostatic agent on a surface thereof a mixture of a clot-promoting amount of thrombin and an amount of epsilon aminocaproic acid (EACA) effective to accelerate the rate of blood clotting induced by the thrombin is useful as a hemostatic patch which is safe, inexpensive and which rapidly controls bleeding from a wound. A patch which rapidly stanches the flow of blood from a lesion on a parenchymal organ by pressing it against the surface of the organ for 3-5 minutes, is produced by applying thrombin, EACA and CaCl. sub. 2 to a rigid sheet of biodegradable foam, such as an absorbable gelatin sponge, and compressing the dry sheet to produce a flexible sheet which conforms to the contour of the organ without the necessity of pre-moistening. The problem associated with thrombin-fibrinogen glues of adhesion of the wounded surface of the organ to adjacent tissue is avoided by applying the hemostatic agent to only the wound-contacting face of the sheet.