Inventors:
Xiangping Zhu - North Grafton MA, US
Zachary Shriver - Cambridge MA, US
Yanjie Jiang - Acton MA, US
Corinne Bauer - Sudbury MA, US
James Eric Anderson - Hudson MA, US
Peter James Ahern - Winchester MA, US
Assignee:
Momenta Pharmaceuticals, Inc. - Cambridge MA
International Classification:
C12Q 1/00, C12Q 1/37, A61K 38/00, C07K 2/00
US Classification:
435 4, 435 23, 435 24, 514 11, 514 179, 530300, 530333, 530335, 530336
Abstract:
Methods for analyzing, selecting, characterizing or classifying compositions of a co-polymer, e. g. , glatiramer acetate are described. The methods entail analysis of pyro-glutamate in the composition, and, in some methods, comparing the amount of pyro-glutamate present in a composition to a reference standard. In some cases, the methods entail treating the co-polymer with pyro-glutamate aminopeptidase to cleave N-terminal pyro-glutamate residues.