JAMES ALFRED NTAMBI
Medical Practice in Madison, WI
License number
Pennsylvania MT189583
Category
Medicine
Type
Graduate Medical Trainee
Address
Address
2
Madison, WI 53711
Pennsylvania
Pennsylvania
Personal information
See more information about JAMES ALFRED NTAMBI at radaris.comName
Address
Phone
4730 Waukesha St, Madison, WI 53705
5738 Kilkenny Pl, Fitchburg, WI 53711
4730 Waukesha St, Madison, WI 53705
5738 Kilkenny Pl, Madison, WI 53711
420 Henry Mall, Madison, WI 53706
Professional information
See more information about JAMES ALFRED NTAMBI at trustoria.com
Methods For Reducing Body Fat And Increasing Lean Body Mass By Reducing Stearoyl-Coa Desaturase 1 Activity
Methods For Reducing Body Fat And Increasing Lean Body Mass By Reducing Stearoyl-Coa Desaturase 1 Activity
US Patent:
2009022, Sep 3, 2009
Filed:
Mar 17, 2009
Appl. No.:
12/405576
Inventors:
James M. Ntambi - Madison WI, US
Alan D. Attie - Madison WI, US
Makoto Miyazaki - Madison WI, US
Jonathan P. Stoehr - Madison WI, US
Alan D. Attie - Madison WI, US
Makoto Miyazaki - Madison WI, US
Jonathan P. Stoehr - Madison WI, US
International Classification:
A61K 31/7088
US Classification:
514 44 A
Abstract:
It is disclosed here that inhibiting the activity of the enzyme stearoyl-CoA desaturase (SCD1) in an animal causes the animal to have less body fat and greater lean body mass. The lower of SCD1 activity level can be accomplished by inhibiting activity of the enzyme or lowering levels of active enzyme in the subject.
Stearoyl-Coa Desaturase 4 Gene
Stearoyl-Coa Desaturase 4 Gene
US Patent:
7285395, Oct 23, 2007
Filed:
Jun 8, 2005
Appl. No.:
11/147606
Inventors:
James M. Ntambi - Madison WI, US
Makoto Miyazaki - Madison WI, US
Makoto Miyazaki - Madison WI, US
Assignee:
Wisconsin Alumni Research Foundation - Madison WI
International Classification:
C12Q 1/26, C12N 9/04, C12N 15/09, C07H 21/04
US Classification:
435 25, 435 691, 435325, 4353201, 435190, 536 232
Abstract:
The cloning of a fourth mouse SCD gene, mSCD4, as well as its corresponding cDNA and amino acid sequences are disclosed. Mouse SCD4 is expressed mainly in the heart tissue and synthesizes the bulk of monounsaturated fatty acids in the heart. The disclosure here enables new tools (e. g. , nucleic acids, polypeptides, antibodies, vectors, recombinant cells, and transgenic and knock-out animals) for studying the function of various SCD isoforms and their connection to various disease conditions. New tools for converting saturated fatty acyl-CoA to monounsaturated acyl-CoA and for identifying SCD modulators including isoform-specific modulators are also enabled. In addition, given that accumulation of lipid in the heart (fatty heart) can have deleterious consequences, the present invention also provides a new prevention and treatment target for fatty heart as well as methods for screening candidate drugs.
Methods And Compositions Using Stearoyl-Coa Desaturase To Identify Triglyceride Reducing Therapeutic Agents
Methods And Compositions Using Stearoyl-Coa Desaturase To Identify Triglyceride Reducing Therapeutic Agents
US Patent:
7696151, Apr 13, 2010
Filed:
Jul 11, 2005
Appl. No.:
11/178808
Inventors:
Michael R. Hayden - Vancouver, CA
Alison J. Brownlie - Vancouver, CA
James M. Ntambi - Madison WI, US
Makoto Miyazaki - Madison WI, US
Alan D. Attie - Madison WI, US
Alison J. Brownlie - Vancouver, CA
James M. Ntambi - Madison WI, US
Makoto Miyazaki - Madison WI, US
Alan D. Attie - Madison WI, US
Assignee:
Xenon Pharmaceuticals Inc. - Burnaby
Wisconsin Alumni Research Foundation - Madison WI
Wisconsin Alumni Research Foundation - Madison WI
International Classification:
G01N 33/53, A61K 38/00, A61K 31/20
US Classification:
514 2, 435 4, 435 71, 435 721, 435 771, 435325, 514560
Abstract:
The use of screening assays based on the role of human stearoyl-CoA desaturase-1 (“hSCD1”) in human diseases, disorders or conditions relating to serum levels of triglyceride, VLDL, HDL, LDL, total cholesterol, or production of secretions from mucous membranes, monounsaturated fatty acids, wax esters, and the like, is disclosed. Also disclosed are conventions useful in the prevention and/or treatment of such diseases.
Methods And Compositions Using Stearoyl-Coa Desaturase To Identify Triglyceride Reducing Therapeutic Agents
Methods And Compositions Using Stearoyl-Coa Desaturase To Identify Triglyceride Reducing Therapeutic Agents
US Patent:
7790408, Sep 7, 2010
Filed:
Aug 1, 2005
Appl. No.:
11/195561
Inventors:
James M. Ntambi - Madison WI, US
Makoto Miyazaki - Madison WI, US
Alan D. Attie - Madison WI, US
Makoto Miyazaki - Madison WI, US
Alan D. Attie - Madison WI, US
Assignee:
Wisconsin Alumni Research Foundation - Madison WI
International Classification:
G01N 33/53, C12Q 1/26, C12N 9/99, C12N 9/02, A01N 61/00, A61K 31/00, A61K 36/00
US Classification:
435 771, 435184, 435189, 435 25, 424769, 514 1
Abstract:
The use of screening assays based on the role of human stearoyl-CoA desaturase-1 (“hSCD1”) in human diseases, disorders or conditions relating to serum levels of triglyceride, VLDL, HDL, LDL, total cholesterol, or production of secretions from mucous membranes, monounsaturated fatty acids, wax esters, and the like, is disclosed. Also disclosed are conventions useful in the prevention and/or treatment of such diseases.
Methods And Compositions Using Stearoyl-Coa Desaturase To Identify Triglyceride Reducing Therapeutic Agents
Methods And Compositions Using Stearoyl-Coa Desaturase To Identify Triglyceride Reducing Therapeutic Agents
US Patent:
7816075, Oct 19, 2010
Filed:
Jul 11, 2005
Appl. No.:
11/178866
Inventors:
Michael R. Hayden - Vancouver, CA
Alison J. Brownlie - Vancouver, CA
James M. Ntambi - Madison WI, US
Makoto Miyazaki - Madison WI, US
Alan D. Attie - Madison WI, US
Alison J. Brownlie - Vancouver, CA
James M. Ntambi - Madison WI, US
Makoto Miyazaki - Madison WI, US
Alan D. Attie - Madison WI, US
Assignee:
Xenon Pharmaceuticals Inc. - Burnaby, B.C.
Wisconsin Alumni Research Foundation - Madison WI
Wisconsin Alumni Research Foundation - Madison WI
International Classification:
G01N 33/53, C12Q 1/26, C12Q 1/32, C12N 9/02, A61K 36/55
US Classification:
435 4, 424768, 435 71, 435 771, 435 25, 435 26, 435183, 435189, 514866, 514909
Abstract:
The use of screening assays based on the role of human stearoyl-CoA desaturase-1 (“hSCD1”) in human diseases, disorders or conditions relating to serum levels of triglyceride, VLDL, HDL, LDL, total cholesterol, or production of secretions from mucous membranes, monounsaturated fatty acids, wax esters, and the like, is disclosed. Also disclosed are conventions useful in the prevention and/or treatment of such diseases.
Method For Increasing Insulin Sensitivity And For Treating And Preventing Type 2 Diabetes
Method For Increasing Insulin Sensitivity And For Treating And Preventing Type 2 Diabetes
US Patent:
2012016, Jun 28, 2012
Filed:
Mar 6, 2012
Appl. No.:
13/412842
Inventors:
James M. Ntambi - Madison WI, US
Alan D. Attie - Madison WI, US
Makoto Miyazaki - Madison WI, US
Alan D. Attie - Madison WI, US
Makoto Miyazaki - Madison WI, US
International Classification:
A61K 39/395, A61P 3/10, C12Q 1/26, A61K 31/7088
US Classification:
4241581, 514 44 A, 435 25
Abstract:
It is disclosed here that insulin sensitivity in a human or non-human animal can be increased by reducing stearoyl-CoA desaturase-1 (SCD1) activity in the animal. This provides a new tool for treating and preventing type 2 diabetes. Also disclosed are methods for identifying agents that can increase insulin sensitivity in a human or non-human animal through determining the agents' effects on SCD1 activity.
Vitamin D Analogs For Obesity Prevention And Treatment
Vitamin D Analogs For Obesity Prevention And Treatment
US Patent:
8188064, May 29, 2012
Filed:
Nov 24, 2004
Appl. No.:
10/997698
Inventors:
Margaret Clagett-Dame - Madison WI, US
Hector F. DeLuca - Deerfield WI, US
Jamie M. Ahrens - Mt. Horeb WI, US
James M. Ntambi - Madison WI, US
Brian Thomson - Madison WI, US
Hector F. DeLuca - Deerfield WI, US
Jamie M. Ahrens - Mt. Horeb WI, US
James M. Ntambi - Madison WI, US
Brian Thomson - Madison WI, US
Assignee:
Wisconsin Alumni Research Foundation - Madison WI
International Classification:
A61K 31/59, C07D 401/00
US Classification:
514167, 552653
Abstract:
Methods for treating and preventing obesity, inhibiting adipocyte differentiation, inhibiting increased SCD-1 gene transcription, and/or reducing body fat in a subject include administering at least one analog of 1α,25-dihydroxyvitamin Dor 1α,25-dihydroxyvitamin Dor a pharmaceutical composition that includes such an analog to a subject in need thereof. The analog may be a 19-nor vitamin D analog such as a compound of formula IA, a compound of formula IB, or a mixture thereof where the variables R, R, and Rhave the values described herein.
Method For Reducing Body Fat And Increasing Lean Body Mass By Reducing Stearoyl-Coa Desaturase 1 Activity
Method For Reducing Body Fat And Increasing Lean Body Mass By Reducing Stearoyl-Coa Desaturase 1 Activity
US Patent:
2011028, Nov 24, 2011
Filed:
Apr 28, 2011
Appl. No.:
13/096056
Inventors:
James M. Ntambi - Madison WI, US
Alan D. Attie - Madison WI, US
Makoto Miyazaki - Madison WI, US
Jonathan P. Stoehr - Madison WI, US
Alan D. Attie - Madison WI, US
Makoto Miyazaki - Madison WI, US
Jonathan P. Stoehr - Madison WI, US
International Classification:
A61K 31/713, A61P 3/06, A61K 9/127
US Classification:
424450, 514 44 A
Abstract:
It is disclosed here that inhibiting the activity of the enzyme stearoyl-CoA desaturase (SCD1) in an animal causes the animal to have less body fat and greater lean body mass. The lower of SCD1 activity level can be accomplished by inhibiting activity of the enzyme or lowering levels of active enzyme in the subject.
Methods For Reducing Body Fat And Increasing Lean Body Mass By Reducing Stearoyl-Coa Desaturase 1 Activity
Methods For Reducing Body Fat And Increasing Lean Body Mass By Reducing Stearoyl-Coa Desaturase 1 Activity
US Patent:
2003006, Apr 3, 2003
Filed:
Mar 8, 2002
Appl. No.:
10/094841
Inventors:
James Ntambi - Madison WI, US
Alan Attie - Madison WI, US
Makoto Miyazaki - Madison WI, US
Jonathan Stoehr - Madison WI, US
Alan Attie - Madison WI, US
Makoto Miyazaki - Madison WI, US
Jonathan Stoehr - Madison WI, US
International Classification:
A61K048/00, A61K031/4439, A61K031/426
US Classification:
514/044000, 514/342000, 514/369000
Abstract:
It is disclosed here that inhibiting the activity of the enzyme stearoyl-CoA desaturase (SCD1) in an animal causes the animal to have less body fat and greater lean body mass. The lower of SCD1 activity level can be accomplished by inhibiting activity of the enzyme or lowering levels of active enzyme in the subject.
Stearoyl-Coa Desaturase Assay
Stearoyl-Coa Desaturase Assay
US Patent:
2006028, Dec 14, 2006
Filed:
Jun 7, 2006
Appl. No.:
11/448198
Inventors:
James Ntambi - Madison WI, US
Makoto Miyazaki - Madison WI, US
Makoto Miyazaki - Madison WI, US
International Classification:
C12Q 1/00, C12Q 1/68, C12Q 1/48, C12P 7/64, A61K 31/202, C12N 1/18
US Classification:
435004000, 435006000, 435134000, 514560000, 435015000, 435254200, 436071000
Abstract:
A yeast-based method for identifying an agent that can modulate the activity of a human or mouse stearoyl-CoA desaturase (SCD) is disclosed. Further disclosed are substrate specificities of various human and mouse SCDs, which facilitate the identification of modulators for human and mouse SCDs.