Inventors:
Richard C. Mulligan - Cambridge MA
James M. Wilson - Waltham MA
Assignee:
Whitehead Institute for Biomedical Research - Cambridge MA
International Classification:
C12N 510, C12N 1586
Abstract:
Fibroblasts transduced with genetic material encoding a polypeptide or protein of interest and, optionally, a selectable marker, as well as methods for making and using the transduced fibroblasts. Such fibroblasts are useful in delivering the encoded polypeptide or protein, such as an enzyme, a hormone or a drug, to an individual who has had a graft or implant of the transduced cells.