JAE YOUNG PARK
Pilots at Triphammer Rd, Ithaca, NY
License number
New York A5190609
Issued Date
Aug 2016
Expiration Date
Aug 2017
Category
Airmen
Type
Authorized Aircraft Instructor
Address
Address
2250 N Triphammer Rd APT R2E, Ithaca, NY 14850
Professional information
Subunit-Selective Nucleic Acid Inhibitors Of Glutamate Receptors
US Patent:
2013028, Oct 31, 2013
Filed:
Jul 15, 2011
Appl. No.:
13/810572
Inventors:
Li Niu - Loudonville NY, US
Zhen Huang - Latham NY, US
Jae Seon Park - Ithaca NY, US
Zhen Huang - Latham NY, US
Jae Seon Park - Ithaca NY, US
Assignee:
The Research Foundation for the State University of New York - Albany NY
International Classification:
C12N 15/115
US Classification:
514 44 R, 536 231, 435375
Abstract:
Inhibitors of AMPA-type glutamate ion channels are useful as biochemical probes for structure-function studies and as drug candidates for a number of neurological disorders and diseases. Disclosed herein is the identification of an RNA inhibitor or aptamer by an in vitro evolution approach and characterization of its mechanism of inhibition on the sites of interaction by equilibrium binding and on the receptor channel-opening rate by a laser-pulse photolysis technique. The aptamer of the invention is a noncompetitive inhibitor of AMPA-type glutamate ion channels, one that selectively inhibits the GluA2QAMPA receptor subunit without any effect on other AMPA receptor subunits or on kainate or NMDA receptors. Furthermore, the aptamer preferentially inhibits the closed-channel state of GluA2Qwith a K=1.5 μM or by ˜15-fold over the open-channel state. The potency and selectivity of this aptamer rival those of small molecule inhibitors. Together, these properties make the aptamers of the present invention promising water-soluble, highly potent, GluA2 subunit-selective drugs.