DR. JACOB ANTHONY MICHAEL, O.D.
Optometry at Colerain Ave, Cincinnati, OH
License number
Ohio 6219
Category
Optometry
Type
Optometrist
Address
Address
8340 Colerain Ave, Cincinnati, OH 45239
Phone
(513) 245-9099
(513) 245-9151 (Fax)
(513) 245-9151 (Fax)
Personal information
See more information about JACOB ANTHONY MICHAEL at radaris.comName
Address
Phone
328 Northview Dr, Powell, OH 43065
2059 Gordon Rd, Cedarville, OH 45314
202 Holland Ave LOT 24, Delphos, OH 45833
1817 Park Ave, Piqua, OH 45356
1060 Lima Ave, Delphos, OH 45833
Professional information
See more information about JACOB ANTHONY MICHAEL at trustoria.com
Oral Administration Of Therapeutic Proteins
Oral Administration Of Therapeutic Proteins
US Patent:
6613332, Sep 2, 2003
Filed:
Mar 29, 2000
Appl. No.:
09/538598
Inventors:
Jacob Gabriel Michael - Cincinnati OH
Allen Litwin - Cincinnati OH
Allen Litwin - Cincinnati OH
Assignee:
The University of Cincinnati - Cincinnati OH
International Classification:
A61K 3900
US Classification:
4241841, 424497, 424482, 424422, 4242781, 4242071, 424464, 424451, 514 2, 514 8, 514 22, 514 23
Abstract:
An orally administrable therapeutic protein is provided by combining the therapeutic protein with a stabilizing agent in an aqueous solution. The solution is coated onto nonpareils and microencapsulated with a water emulsifiable enteric coating composition. The microcapsules are orally administered. The coating protects the protein as it passes through the stomach. Upon reaching the small intestines, the basic pH of the intestinal juices will dissolve the coating, allowing the protein to be released and induce antigen specific immune response which has the specificity of the native molecule. The stabilizing agent protects the therapeutic protein from denaturation during the encapsulation process.
Jacob Anthony Michael, Cincinnati OH
Jacob Anthony Michael, Cincinnati OH
Specialties:
Optometrist
Address:
4601 Eastgate Blvd, Cincinnati, OH 45245
Selective Activation Of A Th1 Or Th2 Lymphocyte Regulated Immune Response
Selective Activation Of A Th1 Or Th2 Lymphocyte Regulated Immune Response
US Patent:
2001002, Oct 4, 2001
Filed:
Jan 8, 2001
Appl. No.:
09/757311
Inventors:
Jacob Michael - Cincinnati OH, US
International Classification:
A61K048/00, A61K039/12, A61K031/739
US Classification:
424/204100, 424/275100, 514/044000, 514/054000
Abstract:
The invention discloses methods for inducing a desired T helper lymphocyte regulated immune response by delivering an immunogen to a preselected region of the gastrointestinal tract of a subject. The invention finds application in the immunological and biomedical fields.
Method Of Immunization With Partially Cationized Substances And Said Partially Cationized Substances
Method Of Immunization With Partially Cationized Substances And Said Partially Cationized Substances
US Patent:
5110794, May 5, 1992
Filed:
Mar 16, 1990
Appl. No.:
7/494678
Inventors:
Jacob G. Michael - Cincinnati OH
Assignee:
Abbott Laboratories - Abbott Park IL
International Classification:
A61K 3912, C07K 300, C07K 1300
US Classification:
514 2
Abstract:
A partially cationized protein-containing substance that exhibits enhanced immunogenicity as compared to the native protein-containing substance and is useful in mammalian immunization by oral or parenteral administration.
Polypeptide Active Pollen Immunosuppressant Fraction
Polypeptide Active Pollen Immunosuppressant Fraction
US Patent:
4338297, Jul 6, 1982
Filed:
Apr 14, 1980
Appl. No.:
6/139881
Inventors:
Jacob G. Michael - Cincinnati OH
Amadeo J. Pesce - Cincinnati OH
Amadeo J. Pesce - Cincinnati OH
International Classification:
A61K 3936, C07G 700
US Classification:
424 91
Abstract:
Polypeptide active pollen immunosuppressant prepared by proteolytic enzyme digestion of pollen antigen and purified by reaction with antipollen antibody and therapeutic use thereof in desensitization.