JACK HOWARD LICHY
Medical Practice in Silver Spring, MD
License number
Pennsylvania MD034930E
Category
Medicine
Type
Medical Physician and Surgeon
Address
Address
2
Silver Spring, MD 20902
Pennsylvania
Pennsylvania
Personal information
See more information about JACK HOWARD LICHY at radaris.comName
Address
Phone
11603 Monticello Ave, Silver Spring, MD 20902
Professional information
Hts-1 Gene, A Human Tumor Suppressor Gene
US Patent:
5491064, Feb 13, 1996
Filed:
Jan 5, 1995
Appl. No.:
8/369043
Inventors:
Jack H. Lichy - Silver Spring MD
Peter M. Howley - Potomac MD
Peter M. Howley - Potomac MD
Assignee:
The United States of America as represented by the Department of Health
and Human Services - Washington DC
and Human Services - Washington DC
International Classification:
C12Q 168, C07H 2104
US Classification:
435 6
Abstract:
A gene which is associated with tumor suppression and is localized on chromosome 11 has now been identified. The identification, localization and sequence of a gene which demonstrates differential expression in a manner that correlates with tumorigenicity suggests that this gene could potentially be used for gene therapy in cancers deleted or altered in their expression of the gene. Furthermore, a gene which is localized on chromosome 11p15, with identified polymorphisms, could be used for analysis of tumor DNA for loss of heterozygosity at chromosome 11p15. This region of chromosome 11 shows frequent loss of heterozygosity (LOH) in many human malignancies. Thus, the determination of LOH at chromosome 11p15 may be useful in predicting the prognosis of that tumor.