ISSAM I. RAAD, M.D.
Osteopathic Medicine at Holcombe Blvd, Houston, TX

6165484, Dec 26, 2000

Aug 25, 1998

9/139522

Issam Raad - Houston TX
Robert Sheretz - Winston-Salem NC
Ray Hachem - Houston TX

Wake Forest University - Winston Salem NC
Board of Regents, The University of Texas Sysytem - Austin TX

A01N 2500, A61K 3170

424405

A pharmaceutical composition comprising at least one antifungal agent and at least one chelator, and a method for administering the pharmaceutical composition to a patient having a fungal infection. Another aspect provides a pharmaceutical composition comprising at least one chelator, at least one antifungal agent and at least one monoclonal antibody, wherein the monoclonal antibody is operatively attached to the chelator, and a method of administering this composition to a patient having a fungal infection.

2003003, Feb 13, 2003

Sep 25, 2002

10/254430

Issam Raad - Houston TX, US
Robert Sherertz - Winston-Salem NC, US
Ray Hachem - Houston TX, US

Board of Regents, The University of Texas System

A61K031/7048, A61K031/195

514/028000, 514/566000

A pharmaceutical composition comprising at least one antifungal agent and at least one chelator, and a method for administering the pharmaceutical composition to a patient having a fungal infection. Another aspect provides a pharmaceutical composition comprising at least one chelator, at least one antifungal agent and at least one monoclonal antibody, wherein the monoclonal antibody is operatively attached to the chelator, and a method of administering this composition to a patient having a fungal infection.

5409467, Apr 25, 1995

Dec 28, 1993

8/174223

Issam I. Raad - Houston TX
Gerald P. Bodey - The Woodlands TX
Alfonso Zermeno - Houston TX

Board of Regents, The University of Texas System - Austin TX

A61M 532

604265

Techniques and apparatus are described for applying alternating and/or pulsed, electrical charges to open circuitry incorporated into medical devices intended to be placed into contact with portions of the body. A catheter assembly is described which comprises a catheter tube, an exterior portion of which is circumferentially surrounded by at least two parallel elongated helical conductive elements which may be operably connected to a power source to create a open circuit to induce an antimicrobial effect in the area proximate the exterior conductive elements through oligodynamic activity. In another embodiment, an oligodynamic dressing is described which incorporates open circuitry which is presented to contact a subject wound.

5217493, Jun 8, 1993

Mar 11, 1992

7/850197

Issam I. Raad - Houston TX
Rabih O. Darouiche - Houston TX

Board of Regents, The University of Texas System - Austin TX

A61F 202

623 11

An implantable medical device having long lasting resistance to staphylococcal biofilm colonization is provided. Implantable medical devices such as catheters, shunts, prosthesis, pacemakers, etc. are susceptible to colonization by biofilm adherent microorganisms, especially staphylococci. While systemic staphylococcal infections are effectively treated by many antibiotics, vancomycin being the antibiotic of choice, this same bacteria when encased in biofilm adhering to indwelling medical devices is generally resistant to antibiotic treatment. By the present invention, the combination of rifampin and minocycline or the combination of rifampin and novobiocin when coated on the surfaces of implantable medical devices unexpectedly provides superior antibacterial activity against staphylococcal biofilm colonization on the coated surface of indwelling medical devices.

6267979, Jul 31, 2001

Aug 25, 1998

9/139521

Issam Raad - Houston TX
Robert Sherertz - Winston-Salem NC

Wake Forest University - Winston-Salem NC
Board of Regents, The University of Texas System - Austin TX

A01N 2500, C02F 508

424405

Control of biofouling in pipes or aqueous systems via the use of compositions and methods that include the combination of a chelator with an antimicrobial agent.

5362754, Nov 8, 1994

Nov 12, 1992

7/975486

Issam Raad - Houston TX
Robert J. Sherertz - Winston-Salem NC

Univ. of TX MD Anderson Cancer Center - Houston TX

A01N 2502, A61M 3100, A61K 31195

514566

Disclosed are pharmaceutical compositions of a mixture of minocycline and EDTA (M-EDTA) and methods of using the compositions in maintaining the patency of a catheter port. Methods for inhibiting the formation of polysaccharide-rich glycocalyx (such as the glycocalyx of staphylococcal organisms) are also provided using an M-EDTA solution. The M-EDTA solution may also be used to pretreat a medical device to prevent adherence of infectious organisms, such as S. epidermidis and S. aureus. The compositions destroy and prevent the formation of polysaccharide-rich glycocalyx. Methods for treating infections of S. epidermidis and S. aureus where glycocalyx formation are provided with an M-EDTA solution. The minocycline and EDTA solutions are included together within a pharmacologically acceptable carrier solution, such as saline.

7713472, May 11, 2010

Jan 11, 2002

10/044842

Issam Raad - Houston TX, US
Hend A. Hanna - Houston TX, US
Nabeel Nabulsi - Katy TX, US

Board of Regents, The University of Texas System - Austin TX

A61L 2/16

422 28, 514642

The present invention provides novel broad spectrum antiseptic compounds that further have properties that allow them to be coated/impregnated into polymer surfaces. Methods for coating these antiseptic compounds onto medical devices especially in-dwelling medical devices to prevent the growth of pathogens in such devices and hence, to prevent infection to patients via such devices are provided. The invention also provides antiseptics that are useful as general surface disinfectants and sterilizers, fluid disinfectants and biocide preservatives.