DR. ISRAEL LOWY, MD, PHD
Osteopathic Medicine at Appleton Pl, Dobbs Ferry, NY
License number
New York 163287
Category
Osteopathic Medicine
Type
Infectious Disease
Address
Address
42 Appleton Pl, Dobbs Ferry, NY 10522
Phone
(914) 674-1146
(914) 674-0967 (Fax)
(914) 674-0967 (Fax)
Professional information
Human Antibodies To Clostridium Difficile Toxins
US Patent:
2013023, Sep 5, 2013
Filed:
Mar 1, 2013
Appl. No.:
13/782444
Inventors:
Carlos Arrecubieta - New York NY, US
Israel Lowy - Dobbs Ferry NY, US
Israel Lowy - Dobbs Ferry NY, US
Assignee:
Regeneron Pharmaceuticals, Inc. - Tarrytown NY
International Classification:
C07K 16/12, A61K 39/40
US Classification:
4241391, 5303895, 4241671, 5303879
Abstract:
The present invention provides fully human antibodies that bind to either toxin A or toxin B of , or to both toxin A and toxin B, compositions comprising the antibodies and methods of use. The antibodies of the invention are useful for neutralizing the toxins from , thus providing a means of treating the disease and symptoms associated with a infection, including the treatment of diarrhea, or pseudomembranous colitis caused by . The antibodies may also prevent the severity and/or duration of the primary disease, or may prevent the number, duration, and/or the severity of recurrences, or relapses of the disease attributed to the presence of . The antibodies of the invention may also be useful for diagnosis of an infection by
Surrogate Therapeutic Endpoint For Anti-Ctla-4 Based Immunotherapy Of Disease
US Patent:
7744875, Jun 29, 2010
Filed:
Oct 27, 2008
Appl. No.:
12/259075
Inventors:
Israel Lowy - Dobbs Ferry NY, US
Geoffrey M. Nichol - Short Hills NJ, US
Geoffrey M. Nichol - Short Hills NJ, US
Assignee:
Medarex, Inc. - Princeton NJ
International Classification:
A61K 39/395
US Classification:
4241301
Abstract:
The present invention provides a method of treatment using human sequence antibodies against human CTLA-4. In particular, methods of treating cancer are provided.
Tnf-Alpha Blocker Treatment For Enterocolitis Associated With Immunostimulatory Therapeutic Antibody Therapy
US Patent:
7611702, Nov 3, 2009
Filed:
Nov 8, 2006
Appl. No.:
11/557835
Inventors:
Steven Fischkoff - Short Hills NJ, US
Israel Lowy - Dobbs Ferry NY, US
Michael Yellin - Montclair NJ, US
James Chung-Yin Yang - Silver Spring MD, US
Israel Lowy - Dobbs Ferry NY, US
Michael Yellin - Montclair NJ, US
James Chung-Yin Yang - Silver Spring MD, US
Assignee:
Medarex, Inc. - Princeton NJ
International Classification:
A61K 39/395, A61K 38/16, C07K 16/28, C07K 16/46
US Classification:
4241301, 4241341, 5303871, 5303873
Abstract:
The present invention provides methods for treating adverse events related to immunotherapy. More specifically, the present invention provides methods for treating the enterocolitis associated with anti-CTLA-4 antibody immunotherapy.
Antibodies Against Clostridium Difficile Toxins And Uses Thereof
US Patent:
8609111, Dec 17, 2013
Filed:
Jun 7, 2012
Appl. No.:
13/490757
Inventors:
Donna M. Ambrosino - Jamaica Plain MA, US
Gregory J. Babcock - Marlborough MA, US
Teresa Broering - Brookline MA, US
Robert Graziano - Frenchtown NJ, US
Hector Javier Hernandez - Canton MA, US
Israel Lowy - Dobbs Ferry NY, US
Robert Mandell - Collins IA, US
Deborah Molrine - Newton MA, US
Hui-Fen Zhang - Bridgewater NJ, US
Gregory J. Babcock - Marlborough MA, US
Teresa Broering - Brookline MA, US
Robert Graziano - Frenchtown NJ, US
Hector Javier Hernandez - Canton MA, US
Israel Lowy - Dobbs Ferry NY, US
Robert Mandell - Collins IA, US
Deborah Molrine - Newton MA, US
Hui-Fen Zhang - Bridgewater NJ, US
Assignee:
University of Massachusetts - Boston MA
Medarex, L.L.C. - Princeton NJ
Medarex, L.L.C. - Princeton NJ
International Classification:
A61K 39/08, A61K 39/00, A61K 39/395, A61K 39/02, A61K 39/38, A61B 5/055, C07H 21/02
US Classification:
4242391, 4241841, 4241391, 4241411, 4241301, 424 934, 4242341, 4241781, 4242361, 4242471, 536 231
Abstract:
Antibodies that specifically bind to toxins of , antigen binding portions thereof, and methods of making and using the antibodies and antigen binding portions thereof are provided herein.
Surrogate Therapeutic Endpoint For Anti-Ctla4-Based Immunotherapy Of Disease
US Patent:
7465446, Dec 16, 2008
Filed:
May 27, 2004
Appl. No.:
10/857749
Inventors:
Israel Lowy - Dobbs Ferry NY, US
Geoffrey M. Nichol - Short Hills NJ, US
Geoffrey M. Nichol - Short Hills NJ, US
Assignee:
Medarex, Inc. - Princeton NJ
International Classification:
A61K 39/395, C07K 16/00, C07K 16/28
US Classification:
4241301, 4241411, 4241431, 4241441, 5303871, 5303881, 5303882, 53038822
Abstract:
The present invention provides a method of treatment using human sequence antibodies against human CTLA-4. In particular, methods of treating cancer are provided.
Human Monoclonal Antibodies Against Protective Antigen
US Patent:
8404820, Mar 26, 2013
Filed:
Oct 7, 2008
Appl. No.:
12/247032
Inventors:
Tibor Keler - Ottsville PA, US
Israel Lowy - Dobbs Ferry NY, US
Laura A. Vitale - Doylestown PA, US
Diann Blanset - Hillsborough NJ, US
Mohan Srinivasan - Cupertino CA, US
Israel Lowy - Dobbs Ferry NY, US
Laura A. Vitale - Doylestown PA, US
Diann Blanset - Hillsborough NJ, US
Mohan Srinivasan - Cupertino CA, US
Assignee:
Medarex, Inc. - Princeton NJ
International Classification:
C07K 16/12, A61K 39/40, G01N 33/569
US Classification:
5303884, 4241421, 4241501, 436512, 436513
Abstract:
Isolated human monoclonal antibodies which bind to Anthrax protective antigen are disclosed. The human antibodies can be produced in a non-human transgenic animal, e. g. , a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are derivatives of the human antibodies (e. g. , bispecific antibodies and immunoconjugates), pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
Human Monoclonal Antibodies Against Bacillus Anthracis Protective Antigen
US Patent:
2005028, Dec 29, 2005
Filed:
May 21, 2004
Appl. No.:
10/850635
Inventors:
Tibor Keler - Ottsville PA, US
Israel Lowy - Dobbs Ferry NY, US
Laura Vitale - Doylestown PA, US
Diann Blanset - Hillsborough NJ, US
Mohan Srinivasan - Cupertino CA, US
Israel Lowy - Dobbs Ferry NY, US
Laura Vitale - Doylestown PA, US
Diann Blanset - Hillsborough NJ, US
Mohan Srinivasan - Cupertino CA, US
Assignee:
MEDAREX, INC. - Princeton NJ
International Classification:
A61K039/40, C12Q001/68, C07H021/04, C12N001/21, C07K016/12
US Classification:
424164100, 435006000, 435069300, 435320100, 435252310, 530388400, 536023700, 800006000
Abstract:
Isolated human monoclonal antibodies which bind to Anthrax protective antigen are disclosed. The human antibodies can be produced in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are derivatives of the human antibodies (e.g., bispecific antibodies and immunoconjugates), pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
Prophylaxis And Treatment Of Enterocolitis Associated With Anti-Ctla-4 Antibody Therapy
US Patent:
2007024, Oct 18, 2007
Filed:
Nov 8, 2006
Appl. No.:
11/557844
Inventors:
Steven Fischkoff - Short Hills NJ, US
Israel Lowy - Dobbs Ferry NY, US
Stephan Targan - Santa Monica CA, US
James Yang - Silver Spring MD, US
Israel Lowy - Dobbs Ferry NY, US
Stephan Targan - Santa Monica CA, US
James Yang - Silver Spring MD, US
International Classification:
A61K 39/395, A61K 31/56
US Classification:
424130100, 514044000
Abstract:
The present invention provides methods for reducing the incidence of adverse events related to immunotherapy. More specifically, the present invention provides methods for reducing the incidence of enterocolitis associated with anti-CTLA-antibody immunotherapy.
Antibodies Against Toxins And Uses Thereof
US Patent:
7625559, Dec 1, 2009
Filed:
Feb 4, 2005
Appl. No.:
11/051453
Inventors:
Donna Ambrosino - Avon MA, US
Gregory J. Babcock - Marlborough MA, US
Teresa Broering - Brookline MA, US
Robert Graziano - Frenchtown NJ, US
Hector Javier Hernandez - Canton MA, US
Israel Lowy - Dobbs Ferry NY, US
Robert Mandell - Upton MA, US
Deborah Molrine - Newton MA, US
Hui-Fen Zhang - Bridgewater NJ, US
Gregory J. Babcock - Marlborough MA, US
Teresa Broering - Brookline MA, US
Robert Graziano - Frenchtown NJ, US
Hector Javier Hernandez - Canton MA, US
Israel Lowy - Dobbs Ferry NY, US
Robert Mandell - Upton MA, US
Deborah Molrine - Newton MA, US
Hui-Fen Zhang - Bridgewater NJ, US
Assignee:
University of Massachusetts - Boston MA
Medarex, Inc. - Princeton NJ
Medarex, Inc. - Princeton NJ
International Classification:
A61K 39/00, A61K 39/395, A61B 5/055, A61K 39/02, A61K 39/38, A61K 39/08, C07H 21/02
US Classification:
4241391, 4241411, 4241301, 424 934, 4242341, 4241841, 4241781, 4242361, 4242471, 536 231
Abstract:
Antibodies that specifically bind to toxins of , antigen binding portions thereof, and methods of making and using the antibodies and antigen binding portions thereof are provided herein.
Antibodies Against Toxins And Uses Thereof
US Patent:
8257709, Sep 4, 2012
Filed:
Jul 31, 2009
Appl. No.:
12/533552
Inventors:
Donna M. Ambrosino - Jamaica Plain MA, US
Gregory J. Babcock - Marlborough MA, US
Teresa Broering - Brookline MA, US
Robert Graziano - Frenchtown NJ, US
Hector Javier Hernandez - Canton MA, US
Israel Lowy - Dobbs Ferry NY, US
Robert Mandell - Collins IA, US
Deborah Molrine - Newton MA, US
Hui-Fen Zhang - Bridgewater NJ, US
Gregory J. Babcock - Marlborough MA, US
Teresa Broering - Brookline MA, US
Robert Graziano - Frenchtown NJ, US
Hector Javier Hernandez - Canton MA, US
Israel Lowy - Dobbs Ferry NY, US
Robert Mandell - Collins IA, US
Deborah Molrine - Newton MA, US
Hui-Fen Zhang - Bridgewater NJ, US
Assignee:
University of Massachusetts - Boston MA
Medarex, Inc. - Princeton NJ
Medarex, Inc. - Princeton NJ
International Classification:
A61K 39/395, A61K 39/00, A61K 39/40, A61K 45/00, A61K 47/00, A61K 39/08, C07K 1/00
US Classification:
4241411, 4241841, 4241671, 4242781, 4242821, 4242471, 424809, 530350
Abstract:
Antibodies that specifically bind to toxins of , antigen binding portions thereof, and methods of making and using the antibodies and antigen binding portions thereof are provided herein.