IRWIN D BERNSTEIN
Medical Practice at Sand Point Way, Seattle, WA
License number
Washington MD00013168
Category
Medical Practice
Type
Pediatric Hematology-Oncology
Address
Address
4800 Sand Point Way NE, Seattle, WA 98105
Phone
(206) 987-2000
Personal information
See more information about IRWIN D BERNSTEIN at radaris.comName
Address
Phone
4949 Stanford Ave NE, Seattle, WA 98105
65 Marion St, Seattle, WA 98104
4949 Stanford Ave NE, Seattle, WA 98105
46 Hilltop Way, Lopez Island, WA 98261
159, Lopez Island, WA 98261
Organization information
See more information about IRWIN D BERNSTEIN at bizstanding.comPediatric Oncology Laboratory
1100 Fairview Ave N #MSD2-373, Seattle, WA 98109
Doing business as:
Pediatric Oncology Laboratory - Irwin D Bernstein MD
Phone:
(206) 667-4886 (Phone)
Categories:
Oncology Physicians & Surgeons, Pediatrics Physicians & Surgeons
Professional information
Irwin I Bernstein, Seattle WA
Specialties:
Pediatric Hematologist / Oncologist
Address:
4800 Sand Point Way Ne, Seattle, WA 98105
Education:
New York University, School of Medicine - Doctor of Medicine*
Children's Hospital & Regional Medical Center - Fellowship - Pediatric Hematology/Oncology (Pediatrics)*
Childrens Hospital Los Angeles - Residency - Pediatrics*
Children's Hospital & Regional Medical Center - Fellowship - Pediatric Hematology/Oncology (Pediatrics)*
Childrens Hospital Los Angeles - Residency - Pediatrics*
Board certifications:
American Board of Pediatrics Certification in Pediatrics*, American Board of Pediatrics Sub-certificate in Pediatric Hematology/Oncology (Pediatrics)*
Dr. Irwin D Bernstein, Seattle WA - MD (Doctor of Medicine)
Specialties:
Pediatric Hematology & Oncology
Address:
Fred Hutchinson Cancer Research
1100 Fairview Ave N SUITE D2-373, Seattle 98109
(206) 667-4886 (Phone)
1100 Fairview Ave N SUITE D2-373, Seattle 98109
(206) 667-4886 (Phone)
Certifications:
Pediatric Oncology & Pediatric Hematology, 1974, Pediatrics, 1973
Awards:
Healthgrades Honor Roll
Languages:
English
Education:
Medical School
New York University
Graduated: 1967
Children's Hospital Los Angeles
Chldns Hosp Med Ctr
New York University
Graduated: 1967
Children's Hospital Los Angeles
Chldns Hosp Med Ctr
Irwin David Bernstein, Seattle WA
Specialties:
Pediatrics, Pediatric Hematology-Oncology, Hematology & Oncology
Work:
Seattle Children's Hospital
4800 Sand Point Way NE, Seattle, WA 98105
4800 Sand Point Way NE, Seattle, WA 98105
Education:
New York University (1967)
Methods For Immortalizing Cells
US Patent:
8071377, Dec 6, 2011
Filed:
Jul 15, 2008
Appl. No.:
12/173185
Inventors:
Irwin D. Bernstein - Seattle WA, US
Barbara Varnum-Finney - Seattle WA, US
Barbara Varnum-Finney - Seattle WA, US
Assignee:
Fred Hutchinson Cancer Research Center - Seattle WA
International Classification:
C12N 5/02
US Classification:
435377, 435372
Abstract:
The present invention provides methods for immortalizing precursor cells that are non-terminally differentiated cells such as stem cells, said methods comprising culturing the precursor cells in the presence of a Notch agonist and one or more growth factors that support the proliferation but not differentiation of the non-terminally differentiated cells. The present invention further provides methods to induce the differentiation of immortalized cells, comprising growing the cells in the presence of a Notch agonist and at least one growth factor which supports the differentiation of the cell into a more specialized cell type. The immortalized and/or differentiated cells of the invention can be used to repopulate cell populations that have been diminished, for example as a result of infection or exposure to certain drugs. The invention further provides a cell culture comprising a population of non-terminally differentiated cells immortalized by the methods of the present invention and kits comprising reagents that promote the immortalization of precursor cells. The invention further provides methods for screening for Notch modulators and for identifying genes involved in processes of cellular differentiation.
Methods For Immortalizing Cells
US Patent:
7399633, Jul 15, 2008
Filed:
Oct 29, 2001
Appl. No.:
10/415310
Inventors:
Irwin D. Bernstein - Seattle WA, US
Barbara Varnum-Finney - Seattle WA, US
Barbara Varnum-Finney - Seattle WA, US
Assignee:
Fred Hutchinson Cancer Research Center - Seattle WA
International Classification:
C12N 5/08
US Classification:
435377, 435372
Abstract:
The present invention provides methods for immortalizing precursor cells that are non-terminally differentiated cells such as stem cells, said methods comprising culturing the precursor cells in the presence of a Notch agonist and one or more growth factors that support the proliferation but not differentiation of the non-terminally differentiated cells. The present invention further provides methods to induce the differentiation of immortalized cells, comprising growing the cells in the presence of a Notch agonist and at least one growth factor which supports the differentiation of the cell into a more specialized cell type. The immortalized and/or differentiated cells of the invention can be used to repopulate cell populations that have been diminished, for example as a result of infection or exposure to certain drugs. The invention further provides a cell culture comprising a population of non-terminally differentiated cells immortalized by the methods of the present invention and kits comprising reagents that promote the immortalization of precursor cells. The invention further provides methods for screening for Notch modulators and for identifying genes involved in processes of cellular differentiation.
Compositions And Methods For Providing Hematopoietic Function Without Hla Matching
US Patent:
2013009, Apr 18, 2013
Filed:
Apr 11, 2011
Appl. No.:
13/640297
Inventors:
Irwin D. Bernstein - Seattle WA, US
Colleen Delaney - Seattle WA, US
Colleen Delaney - Seattle WA, US
Assignee:
FRED HUTCHINSON CANCER RESEARCH CENTER - Seattle WA
International Classification:
A61K 35/48, G06F 19/00
US Classification:
424 937, 435372, 707758
Abstract:
The present invention relates to methods and compositions for providing hematopoietic function in immunodeficient human patients, by selecting an expanded human umbilical cord blood stem/progenitor cell sample without taking into account the HLA-type of the expanded human cord blood stem/progenitor sample or the HLA-type of the patient; and administering the selected expanded human cord blood stem/progenitor cell sample to the patient. Methods for obtaining the expanded human cord blood stem/progenitor cell samples, banks of frozen expanded human cord blood stem/progenitor cell samples, and methods for producing such banks are also provided herein.
Member At Fred Hutchinson Cancer Research Center
Position:
member at Fred Hutchinson Cancer Research Center
Location:
Greater Seattle Area
Industry:
Research
Work:
Fred Hutchinson Cancer Research Center
-
member
Education:
New York University School of Medicine
Radiation Delivery To Lymphoid And Marrow Tissues
US Patent:
5273738, Dec 28, 1993
Filed:
Mar 3, 1990
Appl. No.:
7/562127
Inventors:
Dana C. Matthews - Seattle WA
Irwin D. Bernstein - Seattle WA
John A. Hansen - Mercer Island WA
Fred R. Appelbaum - Seattle WA
Claudio Anasetti - Seattle WA
Paul J. Martin - Seattle WA
Irwin D. Bernstein - Seattle WA
John A. Hansen - Mercer Island WA
Fred R. Appelbaum - Seattle WA
Claudio Anasetti - Seattle WA
Paul J. Martin - Seattle WA
Assignee:
Fred Hutchinson Cancer Research Center - Seattle WA
International Classification:
A61K 4300, A61K 4902
US Classification:
424 11
Abstract:
A method of selectively delivering radiation homogeneously to lymphoid and marrow tissues in vivo including the step of administering an effective dose of a radiolabeled immunological binding partner of a T-200 antigen to a patient is disclosed. Also disclosed are immunological binding partners and compositions based thereon for carrying out the method.
Compositions And Methods For Providing Hematopoietic Function
US Patent:
2013009, Apr 18, 2013
Filed:
Apr 11, 2011
Appl. No.:
13/640298
Inventors:
Irwin D. Bernstein - Seattle WA, US
Colleen Delaney - Seattle WA, US
Colleen Delaney - Seattle WA, US
Assignee:
Fred Hutchinson Cancer Reserach Center - Seattle WA
International Classification:
A61K 35/48, G06F 19/22
US Classification:
424 937, 435372, 707758
Abstract:
The present invention relates to methods and compositions for providing hematopoietic function to human patients in need thereof, by selecting a pool of expanded human cord blood stem/progenitor cell samples for administration to the patient, wherein the samples in the pool collectively do not mismatch the patient at more than 2 of the HLA antigens or alleles typed in the patient; and administering the selected pool of expanded human cord blood stem/progenitor cell samples to the patient. Methods for obtaining the pools of expanded human cord blood stem/pro-genitor cell samples, banks of frozen pools of expanded human umbilical cord blood stem/progenitor cell samples, and methods for producing such banks are also provided herein.