IRVING L SHAPIRO
Architects in Philadelphia, PA

6569442, May 27, 2003

Apr 12, 2001

09/833284

Jean Chin Chin Gan - Ardmore PA
Paul Ducheyne - Rosemont PA
Edward Vresilovic - Philadelphia PA
Irving Shapiro - Philadelphia PA

The Trustees of the University of Pennsylvania - Philadelphia PA

A61F 244

424426, 128898, 424423, 424 937, 435176, 435177, 435180, 435325, 435381, 435395, 435397, 623 1716

Methods and materials are provided for reforming degenerated intervertebral discs of the spine of a vertebrate and in particular the spine of a human. Tissue is evacuated from the nucleus pulposus portion of a degenerated intervertebral disc space, and a biodegradable substrate containing isolated intervertebral disc cells is implanted in the evacuated space for reformation of intervertebral disc tissue. Intervertebral disc cells are provided by digesting intervertebral disc tissue with collagenase and incubating the cells in a medium supplemented with hyaluronidase. The substrate may be bioactive so as to enhance cell function. Substrates include bioactive glass granules, polymer foams and the polymer foams coated with a bioactive gel material produced by a sol-gel process. A polymer foam is dipped into a sol resulting from combining a metal alkoxide precursor with water and acid, residual sol is evacuated from pores of the foam, and remaining sol contained by the foam is allowed to gel. The polymer of the foam may be poly(D,L-lactide-co-glycolide).

5811302, Sep 22, 1998

Jun 2, 1995

8/457454

Paul Ducheyne - Rosemont PA
Ahmed El-Ghannam - Philadelphia PA
Irving Shapiro - Philadelphia PA

The Trustees of the University of Pennsylvania - Philadelphia PA

C12N 508, C12N 500, A61F 228

435402

Novel non-crystalline, porous bioactive glass and ceramic materials that permit the in vitro formation of bone tissue when exposed to a tissue culture medium and inoculated with cells are disclosed. The present invention also discloses methods of treating bioactive glass materials to control pH so that when the glass is exposed to a tissue culture medium and then inoculated with cells, bone tissue growth occurs in vitro. The glass material disclosed is preferably formed from SiO. sub. 2, CaO, Na. sub. 2 O and P. sub. 2 O. sub. 5 and the porous, non-crystalline structure is most preferably created by melting the constituents, cooling and pulverizing the resulting glass, and then forming and hot pressing the powder. The glass of the present invention may be formed to produce templates that are useful for various indications, as well as granules that may be formed into a paste.

5648301, Jul 15, 1997

Jun 2, 1995

8/459002

Paul Ducheyne - Rosemont PA
Ahmed El-Ghannam - Philadelphia PA
Irving Shapiro - Philadelphia PA

Trustees of the University of Pennsylvania - Philadelphia PA

C03C 3087, C03C 3097

501 39

Novel non-crystalline, porous bioactive glass and ceramic materials that permit the in vitro formation of bone tissue when exposed to a tissue culture medium and inoculated with cells are disclosed. The present invention also discloses methods of treating bioactive glass materials to control pH so that when the glass is exposed to a tissue culture medium and then inoculated with cells, bone tissue growth occurs in vitro. The glass material disclosed is preferably formed from SiO. sub. 2, CaO, Na. sub. 2 O and P. sub. 2 O. sub. 5 and the porous, non-crystalline structure is most preferably created by melting the constituents, cooling and pulverizing the resulting glass, and then forming and hot pressing the powder. The glass of the present invention may be formed to produce templates that are useful for various indications, as well as granules that may be formed into a paste.

5643789, Jul 1, 1997

Jul 21, 1994

8/278579

Paul Ducheyne - Rosemont PA
Ahmed El-Ghannam - Philadelphia PA
Irving Shapiro - Philadelphia PA

Trustees of the University of Pennslyvania - Philadelphia PA

C12N 508, C12N 500, A61F 228

435402

Novel non-crystalline, porous bioactive glass and ceramic materials that permit the in vitro formation of bone tissue when exposed to a tissue culture medium and inoculated with cells are disclosed. The present invention also discloses methods of treating bioactive glass materials to control pH so that when the glass is exposed to a tissue culture medium and then inoculated with cells, bone tissue growth occurs in vitro. The glass material disclosed is preferably formed from SiO. sub. 2, CaO, Na. sub. 2 O and P. sub. 2 O. sub. 5 and the porous, non-crystalline structure is most preferably created by melting the constituents, cooling and pulverizing the resulting glass, and then forming and hot pressing the powder. The glass of the present invention may be formed to produce templates that are useful for various indications, as well as granules that may be formed into a paste.

5676720, Oct 14, 1997

Jun 2, 1995

8/459274

Paul Ducheyne - Rosemont PA
Ahmed El-Ghannam - Philadelphia PA
Irving Shapiro - Philadelphia PA

The Trustees of the University of Pennsylvania - Philadelphia PA

C03B 1906, C03B 1908

65 175

A glass material is formed from SiO. sub. 2, CaO, Na. sub. 2 O and P. sub. 2 O. sub. 5 and the porous, non-crystalline structure is most preferably created by melting the constituents, cooling and pulverizing the resulting glass, and then forming and hot pressing the powder. The glass of the present invention may be formed to produce templates that are useful for various indications, as well as granules that may be formed into a paste.

5964807, Oct 12, 1999

Aug 8, 1996

8/694191

Jean Chin Chin Gan - Ardmore PA
Paul Ducheyne - Rosemont PA
Edward Vresilovic - Philadelphia PA
Irving Shapiro - Philadelphia PA

Trustees of the University of Pennsylvania - Philadelphia PA

A61F 244

623 17

Methods of reforming degenerated intervertebral discs are provided in accordance with methods of the invention. Hybrid materials useful in methods of the present invention are also provided.

2003022, Nov 27, 2003

Feb 6, 2003

10/359419

Irving Shapiro - Philadelphia PA, US
Ramesh Rajpurohit - Hillsborough NJ, US
Paul Ducheyne - Rosemont PA, US

A61F002/44

623/017160, 435/398000

The present invention is directed to novel compositions and methods for the treatment of degenerative intervertebral disc disease. In some embodiments, the invention relates to a preparation of nucleus pulposus cells comprising purified nucleus pulposus cells. In some embodiments, the invention relates to methods of treating degenerative intervertebral disc disease in an individual comprising implanting nucleus pulposus cells into the nucleus pulposus space of a degenerated disc of the individual. Other embodiments of the invention relate to methods of generating nucleus pulposus cells.

6240926, Jun 5, 2001

May 19, 1999

9/314511

Jean Chin Chin Gan - Ardmore PA
Paul Ducheyne - Rosemont PA
Edward Vresilovic - Philadelphia PA
Irving Shapiro - Philadelphia PA

The Trustees of the University of Pennsylvania - Philadelphia PA

A61B 1900

128898

Methods of reforming degenerated intervertebral discs. Hybrid materials useful in methods of reforming degenerated intervertebral discs.