Irving Kaufman Arenberg
Physician at Goldsmith Pl, Englewood, CO

6685697, Feb 3, 2004

Sep 25, 2001

09/831487

Irving K. Arenberg - Greenwood Village CO
Michael H. Arenberg - Los Gatos CA
Christine Lemke - Oelixdorf, DE
John A. Berglund - Denver CO

Durect Corporation - Cupertino CA

A61K 922

6048901, 604 2, 604 11

The present invention provides methods and devices for controlled delivery of a therapeutic agent to an internal cavity of the ear, particularly to the inner ear. In general, the invention uses a drug delivery unit for inner ear treatment which employs a portion of carrier media material containing one or more therapeutic agents therein. The carrier media material is designed to release the therapeutic agents in a controlled manner over time. The drug delivery unit is shaped and sized for placement of at least a portion thereof in the round window niche of a patient. The released therapeutic agents come in contact with the round window membrane and pass therethrough into the inner ear for treatment purposes. This system provides many benefits ranging from the ability to deliver drugs in a site specific, highly controlled manner to the transfer of such materials with minimal patient discomfort and monitoring requirements.

6440102, Aug 27, 2002

Jul 23, 1998

09/121460

Irving K. Arenberg - Englewood CO
Michael H. Arenberg - Englewood CO

Durect Corporation - Cupertino CA

A61M 2900

604 9601, 604 9701, 604506, 606108

An apparatus for delivering fluid materials into and out of the inner ear via the round window membrane. A fluid transfer conduit is provided which includes one or more passageways therethrough which may have a semipermeable membrane associated therewith to control fluid flow. Attached to the conduit is an inflatable bladder sized for insertion within the round window niche. When inflated, the bladder engages the internal side wall of the niche, thereby securing the bladder and part of the conduit within the niche. The conduit can then transfer fluids to and from the niche and the fluid-permeable round window membrane therein. Bladder inflation may be achieved through one of the passageways within the conduit which can deliver an inflation fluid into the bladder. Also, the conduit may include an elongate conductive diagnostic member for transferring electrical potentials to and from the inner ear.

5474529, Dec 12, 1995

Apr 21, 1995

8/426215

Irving K. Arenberg - Englewood CO

Inner Ear Medical Delivery Systems, Inc. - Denver CO

A61M 2500

604 21

A therapeutic treatment apparatus for use in the middle and inner ear. The apparatus includes a tubular stem portion attached to a medicine-retaining reservoir with an internal cavity. The reservoir includes multiple pores therethrough or an opening having a semipermeable membrane therein which enables medicine delivery from the reservoir. Such delivery occurs when the reservoir comes in contact with selected middle-inner ear interface tissues. A conductive member for receiving electrical potentials from ear tissues is affixed to the apparatus. Alternatively, the apparatus may include tubular first and second stem portions secured on opposite sides of a reservoir along with a conductive member attached thereto of the type indicated above. This apparatus is surgically inserted so that the first stem portion is placed within the inner ear. At least part of the apparatus (the second stem portion) resides within the external auditory canal.

5501706, Mar 26, 1996

Nov 29, 1994

8/346012

Irving K. Arenberg - Englewood CO

Wildflower Communications, Inc. - Englewood CO

A61F 228

623 16

A medical implant structure and method for making the structure. The implant structure includes a containment member preferably manufactured from collagen (particularly collagen foam) having an open top portion. A supply of a granular implant composition (e. g. hydroxyapatite, natural bone, or bioceramic materials) is positioned within the containment member through the top portion. An activator material (adhesive materials, water, or saline solution) is then added which causes the implant composition to solidify, thereby imparting rigidity to the apparatus. At least one elongate reinforcement member may be positioned within the implant composition during the production process. A cap member may also be placed on the top portion of the containment member. In use, the implant structure is inserted within a patient and positioned adjacent to and against the tissue region to be reinforced. It is then physically shaped to conform with adjacent tissue materials.

6045528, Apr 4, 2000

Jun 13, 1997

8/874208

Irving K. Arenberg - Englewood CO
Michael H. Arenberg - Englewood CO

IntraEar, Inc. - Greenwood Village CO

A61M 100

604 28

An apparatus for transferring fluids into and out of the inner ear through the round window membrane. The apparatus includes a cover member sized for placement over the round window niche. Fluid delivery and fluid extraction conduits are provided which are operatively connected to the cover member so that fluids can pass therethrough. The cover member is positioned over the niche to create a fluid-recieving zone between the cover member and the round window membrane. As a result, fluids can be delivered into or withdrawn from the zone. Alternatively, a single conduit may be used for fluid delivery and extraction. Another variation uses a compressible cover member positioned within the round window niche to form a fluid-receiving zone between the cover member and the round window membrane. The same type of conduit system described above is attached to the compressible cover member.

5421818, Jun 6, 1995

Oct 18, 1993

8/138827

Irving K. Arenberg - Englewood CO

Inner Ear Medical Delivery Systems, Inc. - Denver CO

A61M 2500

604 21

A therapeutic treatment apparatus for use in the middle and inner ear. The apparatus includes a tubular stem portion attached to a medicine-retaining reservoir with an internal cavity. The reservoir includes multiple pores therethrough or an opening having a semipermeable membrane therein which enables medicine delivery from the reservoir. Such delivery occurs when the reservoir comes in contact with selected middle-inner ear interface tissues. A conductive member for receiving electrical potentials from ear tissues is affixed to the apparatus. Alternatively, the apparatus may include tubular first and second stem portions secured on opposite sides of a reservoir along with a conductive member attached thereto of the type indicated above. This apparatus is surgically inserted so that the first stem portion is placed within the inner ear. At least part of the apparatus (the second stem portion) resides within the external auditory canal.

8197461, Jun 12, 2012

Dec 4, 1998

09/205251

Irving K. Arenberg - Englewood CO, US
Michael H. Arenberg - Englewood CO, US
Christine Lemke - Denver CO, US
John A. Berglund - Lafayette CO, US

Durect Corporation - Cupertino CA

A61M 31/00

604500

A specialized drug delivery unit for inner ear treatment which employs a portion of carrier media material containing one or more therapeutic agents therein. The carrier media material is designed to release the therapeutic agents in a controlled manner over time. The drug delivery unit is sized for placement in the round window niche of a patient. The released therapeutic agents come in contact with the round window membrane and pass therethrough into the inner ear for treatment purposes. This system provides many benefits ranging from the ability to deliver drugs in a site specific, highly controlled manner to the transfer of such materials with minimal patient discomfort and monitoring requirements.

5419312, May 30, 1995

Apr 20, 1993

8/050555

Irving K. Arenberg - Englewood CO
Stephen T. Flock - Little Rock AR
Milton Waner - Little Rock AR

Wildflower Communications, Inc. - Englewood CO

A61B 106

128 6

A multi-function endoscope capable of insertion within a body cavity for treatment/diagnostic purposes. The endoscope includes a flexible probe having an optical fiber connected to a laser light source, an optical fiber bundle connected to an illuminating light source, and another optical fiber bundle with a focusing lens thereon connected to a viewing system. The probe further includes an optical fiber having a sensor system associated therewith for making temperature and fluid pressure measurements within the body cavity. Also included are fluid conduits through the probe, and detecting wires for receiving electrical potentials from body cavity tissues. Finally, the probe includes steering wires which, when moved, cause probe movement. The steering wires are moved using a manipulator system consisting of stepper motors connected to a computer controller.

D349904, Aug 23, 1994

Feb 3, 1993

D/004374

Irving K. Arenberg - Greenwood Village CO

Wildflower Communications, Inc. - Englewood CO

D14252