Inventors:
Irving H. Fox - Wellesley MA, US
Catherine Scholz - Woburn MA, US
International Classification:
A61K 39/395, A61P 29/00, A61P 1/04, A61P 1/00
Abstract:
Antibody formulations are described comprising a mixture of a non-reducing sugar, an anti-α4β7 antibody and at least one amino acid. The disclosed formulations have improved stability, reduced aggregate formation, and may retard degradation of the anti-α4β7 antibody therein or exhibit any combinations thereof. The present invention further provides a safe dosing regimen of these antibody formulations that is easy to follow, and which results in a therapeutically effective amount of the anti-α4β7 antibody in vivo.