Inventors:
James Cloyd - Edina MN, US
Angela Birnbaum - Minneapolis MN, US
Ilo Leppik - Minneapolis MN, US
Stephen Collins - Lake Forest IL, US
International Classification:
A61K 31/724, C08B 30/18, C08B 37/16
US Classification:
514058000, 514217000, 536046000
Abstract:
The present invention is directed to a carbamazepine-cyclodextrin inclusion complex useful for the parenteral administration of carbamazepine. The carbamazepine-cyclodextrin inclusion complex is prepared by the admixture of a modified cyclodextrin and carbamazepine in a physiologically acceptable fluid. Modified cyclodextrins include 2-hydroxypropyl-beta-cyclodextrin and sulfoalkyl cyclodextrins. More particularly, the sulfoalkyl cyclodextrins are those described and disclosed in U.S. Pat. Nos. 5,134,127 and 5,376,645. A physiologically acceptable fluid includes sterile isotonic water, Ringer's lactate, D5W (5% dextrose in water), physiological saline, and similar fluids suitable for parenteral administration.