IAN R. RIFKIN, M.D., PHD
Osteopathic Medicine in Boston, MA
License number
Massachusetts 155328
Category
Osteopathic Medicine
Type
Nephrology
Address
Address
725 Albany St Shapiro 7 SUITE A, Boston, MA 02118
Phone
(617) 414-8601
(617) 414-8664 (Fax)
(617) 414-8664 (Fax)
Personal information
See more information about IAN R. RIFKIN at radaris.comName
Address
Phone
147 W Concord St #3, Boston, MA 02118
26 Davis Rd, Auburn, MA 01501
26 Davis Rd, Auburn, MA 01501
557 Columbia Rd, Boston, MA 02125
147 W Concord St, Boston, MA 02118
Professional information
See more information about IAN R. RIFKIN at trustoria.com
Associate Professor Of Medicine At Boston University School Of Medicine
Associate Professor Of Medicine At Boston University School Of Medicine
Position:
Associate Professor of Medicine at Boston University School of Medicine
Location:
Greater Boston Area
Industry:
Hospital & Health Care
Work:
Boston University School of Medicine
-
Associate Professor of Medicine
Dr. Ian R Rifkin - MD (Doctor of Medicine)
Dr. Ian R Rifkin - MD (Doctor of Medicine)
Hospitals:
Boston University Medical Center NEP
650 Albany St SUITE 504, Boston 02118
Boston Medical Center Corporation
1 Boston Medical Ctr Pl, Boston 02118
Boston University Medical Center NEP
650 Albany St SUITE 504, Boston 02118
Boston Medical Center Corporation
1 Boston Medical Ctr Pl, Boston 02118
650 Albany St SUITE 504, Boston 02118
Boston Medical Center Corporation
1 Boston Medical Ctr Pl, Boston 02118
Boston University Medical Center NEP
650 Albany St SUITE 504, Boston 02118
Boston Medical Center Corporation
1 Boston Medical Ctr Pl, Boston 02118
Education:
Medical Schools
University Of The Witwatersrand, Faculty Of Health Sciences
Graduated: 1983
University Of The Witwatersrand, Faculty Of Health Sciences
Graduated: 1983
Ian Rifkin
Ian Rifkin
Location:
Greater Boston Area
Industry:
Higher Education
Skills:
Unix Administration, Release Management, Software Development, Perl, CSS, MySQL, CMS, XML, XHTML, Apache, Unix, XSLT, LDAP, Bash, HTML, SQL, JavaScript, PHP, Subversion, Wordpress, Web Applications, Open Source, Databases, Mac OS X, Microsoft Office, Windows, Linux, Photoshop, jQuery, Data Analysis, Awesomeness, Shibboleth
Method And Composition For Treating Immune Complex Associated Disorders
Method And Composition For Treating Immune Complex Associated Disorders
US Patent:
2010020, Aug 12, 2010
Filed:
Nov 25, 2009
Appl. No.:
12/625815
Inventors:
Elizabeth A. Leadbetter - Roslindale MA, US
Ian R. Rifkin - Boston MA, US
Mark J. Shlomchik - Woodbridge CT, US
Ian R. Rifkin - Boston MA, US
Mark J. Shlomchik - Woodbridge CT, US
Assignee:
Trustees of Boston University - Boston MA
Yale University - New Haven CT
Yale University - New Haven CT
International Classification:
A61K 39/395, A61K 31/7088, A61K 38/16, G01N 33/53, A61P 37/06
US Classification:
4241351, 514 44 A, 514 12, 435 71, 435 724
Abstract:
The present invention provides methods and compositions for treating immune complex associated diseases (ICAD), such as SLE, rheumatoid arthritis, and hepatitis-C related immune complex disease (e.g., cryoglobulinemia) in a subject having an ICAD or at risk for developing ICAD. The invention is based upon the surprising finding that chromatin-containing immune complexes activate autoreactive B cells and dendritic cells by a dual receptor engagement process which, in both cell types, involves a Toll-like receptor (TLR). The methods of treating ICAD comprise administering a compound to an individual in need thereof that either 1) inhibits formation of the immune complex either by preventing formation and/or binding to the TLR, or 2) interferes with binding of an autoantigen-containing immune complex (or the antigenic component thereof) to the TLR, or 3) inhibits signaling pathways initiated by dual engagement of BCR and TLR (in B cells) or FcR and TLR (in dendritic cells) via immune complexed or uncomplexed autoantigens.
Method And Composition For Treating Immune Complex Associated Disorders
Method And Composition For Treating Immune Complex Associated Disorders
US Patent:
2005010, May 19, 2005
Filed:
Sep 9, 2002
Appl. No.:
10/487885
Inventors:
Elizabeth Leadbetter - Roslindale MA, US
Ian Rifkin - Boston MA, US
Mark Shlomchik - Woodbridge CT, US
Ian Rifkin - Boston MA, US
Mark Shlomchik - Woodbridge CT, US
International Classification:
A61K039/395
US Classification:
424144100
Abstract:
The present invention provides methods and compositions for treating immune complex associated diseases (ICAD), such as SLE, rheumatoid arthritis, and hepatitis-C related immune complex disease (e.g., cryoglobulinemia) in a subject having an ICAD or at risk for developing ICAD. The invention is based upon the surprising finding that chromatin-containing immune complexes activate autoreactive B cells and dendritic cells by a dual receptor engagement process which, in both cell types, involves a Toll-like receptor (TLR). The methods of treating ICAD comprise administering a compound to an individual in need thereof that either 1) inhibits formation of the immune complex either by preventing formation and/or binding to the TLR, or 2) interferes with binding of an autoantigen-containing immune complex (or the antigenic component thereof) to the TLR, or 3) inhibits signaling pathways initiated by dual engagement of BCR and TLR (in B cells) or FcR and TLR (in dendritic cells) via immune complexed or uncomplexed autoantigens.