Inventors:
Taebo Sim - San Diego CA, US
Hyun Soo Lee - San Diego CA, US
Pingda Ren - San Diego CA, US
Qiang Ding - San Diego CA, US
Guobao Zhang - San Diego CA, US
Yi Liu - San Diego CA, US
Xia Wang - San Diego CA, US
Tetsuo Uno - San Diego CA, US
Bing Li - San Diego CA, US
Lintong Li - San Diego CA, US
Nathanael Schiander Gray - San Diego CA, US
Shuli You - San Diego CA, US
International Classification:
A61K 31/5355, A61K 31/53, A61K 31/497, A61K 31/513, C07D 413/12, C07D 253/065, C07D 487/04, C07D 413/14, A61P 35/00, C07D 471/04
US Classification:
5142342, 514242, 51425216, 5142621, 544112, 544118, 544182, 544256, 544279, 544 81
Abstract:
The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, BCR-Abl, Bmx, c-Raf, Csk, Fes, FGFR, Flt3, Ikk, IR, JNK, Lck, Mkk, PKC, PKD, Rsk, SAPK, Syk, Trk, BTK, Src, EGFR, IGF, Mek, Ros and Tie2 kinases.