HUONG THI DAO
Cosmetology at Gil Jr Ln, Houston, TX

5444050, Aug 22, 1995

Apr 29, 1994

8/235293

Timothy P. Kogan - Sugar Land TX
Brian Dupre - Houston TX
Ian L. Scott - Houston TX
Karin Keller - Houston TX
Huong Dao - Houston TX
Pamela J. Beck - Houston TX

Texas Biotechnology Corporation - Houston TX

A61K 3170, C07H 1520

514 25

This invention relates to compounds that inhibit the binding of E-selectin and/or P-selectin to sialyl-Lewis. sup. x or sialyl-Lewis. sup. a presented on a cell surface having the general structure ##STR1## wherein X is selected from the group consisting of --(CH. sub. 2). sub. n CO. sub. 2 H, --O(CH. sub. 2). sub. m CO. sub. 2 H, --(CH. sub. 2). sub. n O(CH. sub. 2). sub. m CO. sub. 2 H, --CONH(CH. sub. 2). sub. m CO. sub. 2 H, --CH(OZ)(CO. sub. 2 H), --CH(Z)(CO. sub. 2 H), --(CH. sub. 2). sub. n SO. sub. 3 H, --(CH. sub. 2). sub. n PO. sub. 3 D. sub. 1 D. sub. 2, --NH(CH. sub. 2). sub. m CO. sub. 2 H, --CONH(CHR. sub. 6)CO. sub. 2 H, (1-H-tetrazolyl-5-alkyl-), and --OH; R. sub. 1 and R. sub. 2 are independently selected from the group consisting of hydrogen, alkyl, halogen, --OZ, --NO. sub. 2, --NH. sub. 2 and --NHZ; R. sub.

5622937, Apr 22, 1997

May 1, 1996

8/641341

Timothy P. Kogan - Sugar Land TX
Brian Dupre - Houston TX
Huong Dao - Houston TX
Pamela J. Beck - Houston TX

Texas Biotechnology Corporation - Houston TX

A61K 3170, C07H 1500

514 25

This invention relates to compounds that inhibit the binding of E-selectin or P-selectin to sialyl-Lewis. sup. x or sialyl-Lewis. sup. a presented on a cell surface having the general structure: ##STR1## This invention also relates to methods of inhibiting the binding of E-selectin or P-selectin to sialyl-Lewis. sup. x or sialyl-Lewis. sup. a presented on a cell surface using said compounds and to pharmaceutically active compositions comprising compounds that inhibit the binding of E-selectin to sialyl-Lewis. sup. x and to methods of treatment of septic shock, ARDS, Crohn's disease, chronic inflammatory diseases, such as psoriasis and rheumatoid arthritis, and reperfusion injuries that occurs following heart attacks, strokes and organ transplants and to the treatment of cancer.