Hui-Yin Li
Electrician in Hockessin, DE
License number
Delaware TH-0008575
Issued Date
Oct 19, 2016
Expiration Date
Oct 19, 2017
Category
Electrical Examiners
Type
Homeowner's Permit
Address
Address
2
Hockessin, DE 19707
Professional information
Synthesis Of 1,3,5-Trisubstituted Pyrazoles
US Patent:
6465656, Oct 15, 2002
Filed:
Dec 3, 2001
Appl. No.:
10/005938
Inventors:
Jiacheng Zhou - Hockessin DE
Lynette May Oh - West Chester PA
Pasquale N. Confalone - Greenville DE
Hui-Yin Li - Hockessin DE
Philip Ma - West Chester PA
Lynette May Oh - West Chester PA
Pasquale N. Confalone - Greenville DE
Hui-Yin Li - Hockessin DE
Philip Ma - West Chester PA
Assignee:
Bristol-Myers Squibb Pharma Company - Princeton NJ
International Classification:
C07D26120
US Classification:
548241, 5413697
Abstract:
A novel process for making 1,3,5-trisubstituted pyrazoles of the type shown below from appropriate phenyl hydrazines is described. These compounds are useful as factor Xa inhibitors.
Efficient Process For The Preparation Of [S-(R,S)]-N-[1,3-Benzodioxol-5-Yl)Butyl]-3,3-Diethyl-2[4-[4-Methyl-1-Piper Azinyl)Carbonyl]Phenoxy]-4-Oxo-1-Azetidine Carboxamide, A Human Leukocyte Elastase Inhibitor
US Patent:
6194569, Feb 27, 2001
Filed:
Aug 30, 1999
Appl. No.:
9/385271
Inventors:
Patrick J. Sheeran - Landenberg PA
Luigi Anzalone - West Chester PA
Hui-Yin Li - Hockessin DE
Joseph M. Fortunak - Newark DE
Louis Storace - Middletown DE
Luigi Anzalone - West Chester PA
Hui-Yin Li - Hockessin DE
Joseph M. Fortunak - Newark DE
Louis Storace - Middletown DE
Assignee:
DuPont Pharmaceuticals Company - Wilmington DE
International Classification:
C07D40312, C07D40514
US Classification:
540360
Abstract:
Processes for the preparation of [S-(R,S)]-N-[1,3-benzodioxol-5-yl)butyl]-3,3-diethyl-2[4-[4-methyl-1-piper azinyl)carbonyl]phenoxy]-4-oxo-l-azetidine carboxamide, a useful inhibitor of human leukocyte elastase (HLE), are described. The process including (a) contacting a compound of formula (II): ##STR1##
with a compound of formula (III): ##STR2##
in a first polar solvent system in the presence of an aqueous base and a phase transfer catalyst, to form the title compound, or a salt form thereof.
Aminoindane Compounds And Use Thereof In Treating Pain
US Patent:
2012021, Aug 23, 2012
Filed:
Feb 18, 2012
Appl. No.:
13/400039
Inventors:
Scott Kevin Thompson - Phoenixville PA, US
Tony Priestley - West Chester PA, US
Roger Astbury Smith - Chester Springs PA, US
Ashis K. Saha - Stow MA, US
Sonali Rudra - Kolkata, IN
Arun Kuma Hajra - Kolkata, IN
Dipanwita Chatterjee - Kokata, IN
Carl Henry Behrens - Newark DE, US
Yigang He - Ewing NJ, US
Hui-Yin Li - Hockessin DE, US
Tony Priestley - West Chester PA, US
Roger Astbury Smith - Chester Springs PA, US
Ashis K. Saha - Stow MA, US
Sonali Rudra - Kolkata, IN
Arun Kuma Hajra - Kolkata, IN
Dipanwita Chatterjee - Kokata, IN
Carl Henry Behrens - Newark DE, US
Yigang He - Ewing NJ, US
Hui-Yin Li - Hockessin DE, US
International Classification:
A61K 31/452, C07D 207/09, A61K 31/40, C07D 401/12, A61K 31/4545, A61K 31/506, C07D 417/12, A61K 31/454, C07D 498/10, A61K 31/5386, C07D 405/12, A61K 31/453, C07D 471/10, A61K 31/438, A61P 29/00, A61P 17/04, C07D 211/26
US Classification:
5142355, 546205, 514319, 548566, 514408, 546194, 514318, 544330, 514275, 544 71, 546197, 514321, 546 16, 514278
Abstract:
The present application provides novel aminoindane compounds and methods for preparing and using these compounds. These compounds are useful in treating pain and/or itch in patients by administering one or more of the compounds to a patient. The methods include administering a compound of formula (I) or (II) and a TRPV 1 receptor activator. In one embodiment, the TRPV 1 receptor activator is lidocaine.
Particulates Of A Crth2 Antagonist
US Patent:
8507005, Aug 13, 2013
Filed:
Jun 18, 2008
Appl. No.:
12/665706
Inventors:
Tai Wei Ly - San Diego CA, US
Hui-Yin Li - Hockessin DE, US
Hui-Yin Li - Hockessin DE, US
Assignee:
Actimis Pharmaceuticals, Inc. - San Diego CA
International Classification:
A61K 9/14, C07D 239/46, A61K 31/505, A61P 17/06, A61P 17/00, B32B 5/16
US Classification:
424489, 544322, 514256, 428402
Abstract:
Provided herein are particulates of {4,6-bis(dimethylamino)-2-(4-(4-(trifluoromethyl)benzamido)benzyl)pyrimidin-5-yl}acetic acid in amorphous or crystalline forms, processes for their preparation, pharmaceutical compositions comprising them, and methods of their use for treating, preventing, or ameliorating one or more symptoms of a CRTH2-mediated disorder or disease.
Piperidin-4-Yl Azetidine Derivatives As Jak1 Inhibitors
US Patent:
2011022, Sep 15, 2011
Filed:
Mar 9, 2011
Appl. No.:
13/043986
Inventors:
Taisheng Huang - Wilmington DE, US
Anlai Wang - Wilmington DE, US
Ling Quan Kong - Hockessin DE, US
Hai Fen Ye - Newark DE, US
Wenqing Yao - Kennett Square PA, US
James D. Rodgers - Landenberg PA, US
Stacey Shepard - Wilmington DE, US
Haisheng Wang - Hockessin DE, US
Lixin Shao - Newark DE, US
Hui-Yin Li - Hockessin DE, US
Qun Li - Newark DE, US
Anlai Wang - Wilmington DE, US
Ling Quan Kong - Hockessin DE, US
Hai Fen Ye - Newark DE, US
Wenqing Yao - Kennett Square PA, US
James D. Rodgers - Landenberg PA, US
Stacey Shepard - Wilmington DE, US
Haisheng Wang - Hockessin DE, US
Lixin Shao - Newark DE, US
Hui-Yin Li - Hockessin DE, US
Qun Li - Newark DE, US
International Classification:
A61K 31/519, C07D 487/04, C07D 471/04, C12N 9/99, A61P 35/00, A61P 19/02, A61P 25/00, A61P 17/00, A61P 29/00, A61P 19/08, A61P 17/06, A61P 35/02
US Classification:
51421021, 544280, 546113, 544333, 544405, 435184
Abstract:
The present invention provides piperidin-4-yl azetidine derivatives, as well as their compositions and methods of use, that modulate the activity of Janus kinase 1 (JAK1) and are useful in the treatment of diseases related to the activity of JAK1 including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.
Polymorphic Forms Of 6-11 Bicyclic Ketolide Derivatives
US Patent:
7384921, Jun 10, 2008
Filed:
Feb 14, 2005
Appl. No.:
11/057476
Inventors:
Datong Tang - Watertown MA, US
Guoyou Xu - Newton MA, US
Yonghua Gai - North Grafton MA, US
Zhe Wang - Hockessin DE, US
Yat Sun Or - Watertown MA, US
Hui-Yin Li - Hockessin DE, US
Guoyou Xu - Newton MA, US
Yonghua Gai - North Grafton MA, US
Zhe Wang - Hockessin DE, US
Yat Sun Or - Watertown MA, US
Hui-Yin Li - Hockessin DE, US
Assignee:
Enanta Pharmaceuticals, Inc. - Watertown MA
International Classification:
A61K 31/70, C07H 17/08
US Classification:
514 29, 536 74
Abstract:
The present invention includes EP-13420 polymorphic crystalline forms: Form I, Form II, Form Ia, and monohydrate and amorphous EP-13420 which posses distinct physical properties. In another embodiment of the present invention, there are provided methods of producing the various polymorphic forms in pure form or in combination with one another. The present invention also provides pharmaceutical compositions and formulations comprising the polymorphic and amorphous forms and methods of treating bacterial infections by administering the pharmaceutical compositions to a subject in need of such treatment.
Solid Forms Of (S)-2-Amino-3-(4-(2-Amino-6-((R)-2,2,2-Trifluoro-1-(3'-Methoxybiphenyl-4-Yl)Ethoxy)Pyrimidin-4-Yl)Phenyl)Propanoic Acid And Methods Of Their Use
US Patent:
2009009, Apr 16, 2009
Filed:
Oct 7, 2008
Appl. No.:
12/246735
Inventors:
Shinya Iimura - Lawrenceville NJ, US
Hui-Yin Li - Hockessin DE, US
Qiuling Song - Newark DE, US
Wenxue Wu - Princeton Junction NJ, US
Matthew Mangzhu Zhao - Edison NJ, US
Hui-Yin Li - Hockessin DE, US
Qiuling Song - Newark DE, US
Wenxue Wu - Princeton Junction NJ, US
Matthew Mangzhu Zhao - Edison NJ, US
International Classification:
A61K 31/505, C07D 239/26, A61P 1/00
US Classification:
514256, 544335
Abstract:
Solid forms of (S)-2-amino-3-(4-(2-amino-6-((R)-2,2,2-trifluoro-1-(3′-methoxybiphenyl-4-yl)ethoxy)pyrimidin-4-yl)phenyl)propanoic acid and salts thereof are disclosed.
Salts Of The Janus Kinase Inhibitor (R)-3-(4-(7H-Pyrrolo[2,3-D]Pyrimidin-4-Yl)-1H-Pyrazol-1-Yl)-3-Cyclopentylpropanenitrile
US Patent:
2008031, Dec 18, 2008
Filed:
Jun 12, 2008
Appl. No.:
12/137892
Inventors:
James D. Rodgers - Landenberg PA, US
Hui-Yin Li - Hockessin DE, US
Hui-Yin Li - Hockessin DE, US
Assignee:
INCYTE CORPORATION - Wilmington DE
International Classification:
A61K 31/519, C07D 487/04, A61P 37/00, A61P 17/00, A61P 31/12, A61P 35/00, A61P 29/00, A61P 9/00
US Classification:
5142651, 544280
Abstract:
The present invention provides salt forms of (R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile that are useful in the modulation of Janus kinase activity and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.
Synthesis Of 4,5-Dihydro-Pyrazolo [3,4-C] Pyrid-2-Ones
US Patent:
6919451, Jul 19, 2005
Filed:
Dec 3, 2002
Appl. No.:
10/308741
Inventors:
Jiacheng Zhou - Hackessin DE, US
Lynette M. Oh - West Chester PA, US
Philip Ma - West Chester PA, US
Hui-Yin Li - Hockessin DE, US
Pasquale Confalone - Greenville DE, US
Lynette M. Oh - West Chester PA, US
Philip Ma - West Chester PA, US
Hui-Yin Li - Hockessin DE, US
Pasquale Confalone - Greenville DE, US
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
C07D471/04
US Classification:
544127, 544333, 544405, 546119, 546120
Abstract:
A novel process and intermediates thereof for making 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones of the type shown below from appropriate phenyl hydrazines is described. These compounds are useful as factor Xa inhibitors.
Synthesis Of 4,5-Dihydro-Pyrazolo[3,4-C]Pyrid-2-Ones
US Patent:
7153960, Dec 26, 2006
Filed:
Jun 8, 2005
Appl. No.:
11/147634
Inventors:
Jiacheng Zhou - Hockessin DE, US
Lynette M. Oh - West Chester PA, US
Philip Ma - West Chester PA, US
Hui-Yin Li - Hockessin DE, US
Pasquale Confalone - Greenville DE, US
Lynette M. Oh - West Chester PA, US
Philip Ma - West Chester PA, US
Hui-Yin Li - Hockessin DE, US
Pasquale Confalone - Greenville DE, US
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
C07D 413/00, C07D 401/00, C07D 403/00, C07D 471/02, C07D 491/02
US Classification:
544127, 544333, 546119
Abstract:
A novel process and intermediates thereof for making 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones of the type shown below from appropriate phenyl hydrazines is described.