Inventors:
Hui Chen - Palo Alto CA, US
Aviv Gazit - Jerusalem, IL
Alexander Levitzki - Jerusalem, IL
Klaus Peter Hirth - San Francisco CA, US
Elaina Mann - Oakland CA, US
Peng Cho Tang - Moraga CA, US
Laura K. Shawver - San Francisco CA, US
Jianming Tsai - San Francisco CA, US
Assignee:
Yissum Research and Development Company of the Hebrew University of Jerusalem - Jerusalem
Sugen, Inc. - South San Francisco CA
International Classification:
A61K 31/275
Abstract:
The present invention concerns compounds and their use to inhibit the activity of a receptor tyrosine kinase. The invention is preferably used to treat cell proliferative disorders such as cancers characterized by over-activity or inappropriate activity HER2 or EGFR.