HUBERT M QUINN
Broker in Boston, MA

5919368, Jul 6, 1999

Dec 8, 1997

8/987170

Hubert M. Quinn - Brighton MA
Joseph J. Takarewski - Woburn MA

Cohesive Technologies, Inc. - Franklin MA

B01D 1508

210635

A method of and apparatus for liquid chromatography at improved analytical and preparative speeds and quantities involves flow of fluids through the column at flow rates sufficient to induce turbulent flow in those fluids. In one embodiment, the apparatus and method includes a substantially uniform chromatography column created by packing together a multiplicity of rigid, solid, porous particles having diameters of not less than about 30. mu. m, surfaces of the particles being chromatographically active. A fluid mixture containing at least one solute that is reactive with the particle surfaces is injected into the column and subsequently eluted therefrom by a eluant fluid flow, both the injection and elution being effected at a velocity sufficient to induce flow within at least a substantial portion of the interstitial volume between the particles at a reduced velocity greater than about 5,000.

5772874, Jun 30, 1998

Jun 11, 1996

8/661367

Hubert M. Quinn - Brighton MA
Joseph J. Takarewski - Woburn MA

Cohesive Technologies, Inc. - Acton MA

B01D 1508

2101982

A method of and apparatus for liquid chromatography at improved analytical and preparative speeds and quantities involves flow of fluids through the column at flow rates sufficient to induce turbulent flow in those fluids. In one embodiment, the apparatus and method includes a substantially uniform chromatography column created by packing together a multiplicity of rigid, solid, porous particles having diameters of not less than about 30. mu. m, surfaces of the particles being chromatographically active. A fluid mixture containing at least one solute that is reactive with the particle surfaces is injected into the column and subsequently eluted therefrom by a eluant fluid flow, both the injection and elution being effected at a velocity sufficient to induce flow within at least a substantial portion of the interstitial volume between the particles at a reduced velocity greater than about 5,000.

2006016, Aug 3, 2006

Feb 1, 2005

11/048335

Hubert Quinn - Brighton MA, US

B01D 15/08

210656000, 436161000, 436178000

The present invention relates to a method and apparatus for chromatographically analyzing/purifying samples in a detector, comprising an autosampler to contain a sample for chromatographic analysis and a chromatographic system comprising a loading pump, and an eluting pump and at least one chromatography column. A detector is included for detecting compounds in the sample from the chromatography system. The loading pump establishes a flow of a loading solvent through the autosampler to dissolve the sample and to load the sample on the chromatography column. The eluting pump establishes a flow of eluent of increasing strength through the column and to the detector. In addition, the present invention provides improved methods of screening and preparative chromatography.

2010007, Mar 25, 2010

Dec 1, 2009

12/628717

Hubert Quinn - Brighton MA, US

G01N 30/02

73 6155

The present invention relates to a method and apparatus for chromatographically analyzing/purifying samples in a detector, comprising an autosampler to contain a sample for chromatographic analysis and a chromatographic system comprising a loading pump, and an eluting pump and at least one chromatography column. A detector is included for detecting compounds in the sample from the chromatography system. The loading pump establishes a flow of a loading solvent through the autosampler to dissolve the sample and to load the sample on the chromatography column. The eluting pump establishes a flow of eluent of increasing strength through the column and to the detector. In addition, the present invention provides improved methods of screening and preparative chromatography.

5795469, Aug 18, 1998

Jan 21, 1997

8/785324

Hubert M. Quinn - Brighton MA
Rebecca A. Menapace - Framingham MA
Charles J. Oberhauser - Belmont MA

Cohesive Technologies, Inc. - Acton MA

B01D 1508

2101982

High pressure liquid chromatographic apparatus in which a fluid mixture containing at least one solute that is reactive with chromatographically reactive surfaces in the column is loaded into the column, and a number of plugs of different eluant fluids are injected into that column. The injections are made in a manner that minimizes the amount of eluant required. In one embodiment, the injections are made to insure that flow of at least the eluant fluids through the column will occur, preferably with a substantially flat wave front, at speeds corresponding to reduced velocities greater than about 5,000, i. e. at flow rates sufficient to induce turbulent flow in those fluids, thereby minimizing the time required for the entire succession of mixture and eluant fluids to traverse the column. In other embodiments, the injections are made substantially simultaneously at spatially separated points adjacent the entrance to the column or are made in sequence to a single location adjacent the entrance to the column, in either case the fluids then tend to travel through the column at a common group velocity as closely bunched fluid plugs.

5968367, Oct 19, 1999

Jan 7, 1998

9/003856

Hubert M. Quinn - Brighton MA
Rebecca A. Menapace - Framingham MA
Charles J. Oberhauser - Belmont MA

Cohesive Technologies, Inc. - Franklin MA

B01D 1508

210656

High pressure liquid chromatographic apparatus in which a fluid mixture containing at least one solute that is reactive with chromatographically reactive surfaces in the column is loaded into the column, and a number of plugs of different eluant fluids are injected into that column. The injections are made in a manner that minimizes the amount of eluant required. In one embodiment, the injections are made to insure that flow of at least the eluant fluids through the column will occur, preferably with a substantially flat wave front, at speeds corresponding to reduced velocities greater than about 5,000, i. e. at flow rates sufficient to induce turbulent flow in those fluids, thereby minimizing the time required for the entire succession of mixture and eluant fluids to traverse the column. In other embodiments, the injections are made substantially simultaneously at spatially separated points adjacent the entrance to the column or are made in sequence to a single location adjacent the entrance to the column, in either case the fluids then tend to travel through the column at a common group velocity as closely bunched fluid plugs.

7767463, Aug 3, 2010

Jun 15, 2007

11/763983

Hubert M Quinn - Brighton MA, US
Elizabeth Williams - Hopkinton MA, US

Cohesive Technologies, Inc. - Franklin MA

G01N 30/02, G01N 30/62

436161, 73 5401, 73 5406, 73 6147, 73 6152, 73 6158, 73700

A method and system of screening or selecting a mobile phase eluent for a chromatography column is provided. A sample for chromatographic analysis or purification is combined with a solvent and passed through a membrane. A pressure measurement is taken of the sample/solvent combination in the system prior to the membrane. The pressure measurement may be compared to a second pressure and an appropriate solvent may be selected based on the relationship between the first measured pressure and the second pressure.

6149816, Nov 21, 2000

Jan 3, 2000

9/476257

Hubert M. Quinn - Brighton MA
John E. Brann - Boylston MA

Cohesive Technologies, Inc. - Franklin MA

B01D 1508

210635

A system for separating compounds of relatively low molecular weight substantially not greater than about one kilodalton from compounds having relatively high molecular weights substantially an order of magnitude greater or more than the low molecular weight compounds in a liquid mixture. The system includes a chromatographic column packed with uniformly distributed rigid, solid, porous particles having chromatographically active, hydrophobic surfaces, average diameters of not less than about 30. mu. m, and average pore diameters sufficiently small to substantially exclude introduction of the compounds of relatively high molecular weight into the pores. The mixture is pumped through the interstitial volume between the particles at a reduced velocity greater than about 5,000, until a band of the high molecular weight compounds exits the column. The low molecular weight compounds are then eluted and are recovered separately from the relatively high molecular weight compounds. Spectrographic identification of the recovered low molecular weight compounds can then be made, preferably by ultraviolet absorption or by mass spectrograph.

6110362, Aug 29, 2000

Nov 19, 1997

8/974336

Hubert M. Quinn - Brighton MA
John E. Brann - Boylston MA

Cohesive Technologies, Inc. - Franklin MA

B01D 1508

2101982

A system for separating compounds of relatively low molecular weight substantially not greater than about one kilodalton from compounds having relatively high molecular weights substantially an order of magnitude greater or more than the low molecular weight compounds in a liquid mixture. The system includes a chromatographic column packed with uniformly distributed rigid, solid, porous particles having chromatographically active, hydrophobic surfaces, average diameters of not less than about 30. mu. m, and average pore diameters sufficiently small to substantially exclude introduction of the compounds of relatively high molecular weight into the pores. The mixture is pumped through the interstitial volume between the particles at a reduced velocity greater than about 5,000, until a band of the high molecular weight compounds exits the column. The low molecular weight compounds are then eluted and are recovered separately from the relatively high molecular weight compounds. Spectrographic identification of the recovered low molecular weight compounds can then be made, preferably by ultraviolet absorption or by mass spectrograph.