Huang Guo
Nursing at Round Trl Dr, Pittsford, NY
License number
Florida 9459648
Issued Date
May 15, 2017
Effective Date
May 15, 2017
Expiration Date
Apr 30, 2019
Category
Health Care
Type
Registered Nurse
Address
Address
2
12 Round Trail Dr, Pittsford, NY 14534
1000 South Ave South, Rochester, NY 14620
1000 South Ave South, Rochester, NY 14620
Phone
(585) 350-8258
Professional information
Research Assistant Professor At University Of Rochester
Location:
Rochester, New York Area
Industry:
Higher Education
Activated Protein C Inhibits Undesirable Effects Of Plasminogen Activator In The Brain
US Patent:
2008030, Dec 11, 2008
Filed:
Jul 25, 2005
Appl. No.:
11/632850
Inventors:
Berislav V. Zlokovic - Rochester NY, US
Dong Liu - Rochester NY, US
Tong Cheng - Webster NY, US
Huang Guo - Pittsford NY, US
Dong Liu - Rochester NY, US
Tong Cheng - Webster NY, US
Huang Guo - Pittsford NY, US
International Classification:
A61K 38/48, C40B 30/06, A61P 9/00
US Classification:
424 9464, 506 10
Abstract:
Activated protein C (APC), a prodrug, and/or a variant of APC may be used to inhibit undesirable effects of plasminogen activator: e.g., apoptosis or cell death of neurons and endothelial cells, brain hemorrhage or intracerebral bleeding, and/or tissue damage in a subject's brain. Inhibition appears to act through the extrinsic pathway of death receptor signal transduction. This represents an improvement in treatment using plasminogen activator (e.g., fibrinolysis). By reducing undesirable effects, the window for fibrinolytic therapy by plasminogen activator may be widened.