Inventors:
Denise Demarais - Saratoga CA, US
Hanson Gifford, III - Woodside CA, US
Mark Deem - Mountain View CA, US
Howard R. Levin - Teaneck NJ, US
Mark Gelfand - New York NY, US
Nicolas Zadno - Fremont CA, US
Assignee:
Ardian, Inc. - Mountain View CA
International Classification:
A61B 18/00, A61N 1/36
Abstract:
Methods and apparatus are provided for monopolar neuromodulation, e.g., via a pulsed electric field. Such monopolar neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, monopolar neuromodulation is applied to neural fibers that contribute to renal function. In some embodiments, such monopolar neuromodulation is performed bilaterally.