Inventors:
Sandhya Goyal - Ryebrook NY, US
Subhas Kundu - Tappan NY, US
Daniel Moros - Latchmont NY, US
Howard Rutman - New York NY, US
Avraham Yacobi - Englewood NJ, US
Assignee:
Taro Pharmaceuticals North America, Inc. - Grand Cayman
International Classification:
A01N 57/10, A01N 57/12, A01N 25/02, A61K 9/08, A61K 31/661, A61K 47/10, A61K 47/14, A61P 33/14
Abstract:
The present invention provides a topical gel pharmaceutical formulation of insecticide suitable for treating an ectoparasite in a mammal, comprising: a) about 0. 1-10% by weight of an insecticide; b) at least about 75% by weight of an organic solvent selected from the group consisting of a lower alkyl alcohol, a ketone, a glycol and a mixture thereof, wherein the organic solvent contains at least about 40% by weight of the lower alkyl alcohol; and c) at least one polymer selected from the group consisting of a cellulosic polymer, acrylates, methacrylates, and polyvinyl pyrrolidone. The present topical formulations encompass a non-flammable solvent for malathion effective in killing head lice. The present gel pharmaceutical formulation preferably contains malathion and optionally contains isopropyl myristate. The present invention further provides a process of preparing as well as a method of treating ectoparasites in a mammal using the same.