DR. HOWARD I. MAIBACH, M.D.
Dermatology at Divisadero St, San Francisco, CA

7205003, Apr 17, 2007

Sep 23, 2002

10/252784

Howard I. Maibach - San Francisco CA, US
Eric C. Luo - Plano TX, US
Tsung-Min Hsu - San Diego CA, US

Dermatrends, Inc. - Minneapolis MN

A61K 6/00, A61K 7/00, A61K 33/00, A61K 59/00

424722, 424401

A composition and method are provided for alleviating the dermatological signs of intrinsic and extrinsic aging. A topical formulation containing a cosmeceutically active base, wherein the formulation provides a pH in the range of about 8. 0 to 13. 0 at the skin surface, is applied to the skin in order to prevent or treat aging-related skin conditions such as wrinkles, dry skin, age spots, sun damage (particularly UV radiation-induced oxidative stress), blemishes, hyperpigmented skin, age spots, increased skin thickness, loss of skin elasticity and collagen content, dry skin, lentigines and melasmas. The cosmeceutically active base is either an inorganic base, such as an inorganic hydroxide, an inorganic oxide, or a metal salt of a weak acid, or an organic base, particularly a nitrogenous base such as may be selected from primary amines, secondary amines, tertiary amines, amides, oximes, nitrites, aromatic and non-aromatic nitrogen-containing heterocycles, urea, and mixtures thereof.

2003005, Mar 27, 2003

Sep 24, 2001

09/962622

Howard Maibach - San Francisco CA, US
Eric Luo - Plano TX, US
Tsung-Min Hsu - San Diego CA, US

A61K007/00

424/401000

A composition and method are provided for alleviating the dermatological signs of intrinsic and extrinsic aging. A topical formulation containing a cosmeceutically active base, wherein the formulation has a pH in the range of about 7.5 to 13.0, is applied to the skin in order to prevent or treat aging-related skin conditions such as wrinkles, dry skin, age spots, sun damage (particularly UV radiation-induced oxidative stress), blemishes, hyperpigmented skin, age spots, increased skin thickness, loss of skin elasticity and collagen content, dry skin, lentigines and melasmas. The cosmeceutically active base is either a hydroxide-releasing agent, such as an inorganic hydroxide, an inorganic oxide, or a metal salt of a weak acid, or is an organic base, particularly a nitrogenous base.

2003023, Dec 25, 2003

Sep 23, 2002

10/254020

Howard Maibach - San Francisco CA, US
Eric Luo - Plano TX, US
Tsung-Min Hsu - San Diego CA, US

A61K007/135

424/062000

Provided are methods and topical pharmaceutical formulations for skin lightening. The invention involves the topical administration of a pharmacologically active base in a formulation having a pH of about 8.0 to about 13.0, preferably about 8.0 to 11.5, more preferably about 8.5 to 11.5, and most preferably about 8.5 to 10.5. These basic formulations can be used to treat regions of hyperpigmented skin, comprising, as examples, age spots, freckles, disease-related hyperpigmented skin, melasma related to pregnancy or the use of oral contraceptives, and hyperpigmented skin due to chemical exposure or ingestion.

2003023, Dec 25, 2003

Jun 21, 2002

10/176963

Howard Maibach - San Francisco CA, US
Eric Luo - Plano TX, US
Tsung-Min Hsu - San Diego CA, US

A61K033/06, A01N033/02, A61K031/13, A61K031/495

424/682000, 424/722000, 514/663000, 514/252120

Provided are methods and topical pharmaceutical formulations for use in the treatment of warts. The invention involves the topical administration of a pharmacologically active base in a formulation having a pH of about 7.5 to about 13.0, preferably about 8.0 to 11.5, and most preferably about 8.5 to 10.5. These basic formulations can be used to treat human papilloma virus infections, particularly cutaneous warts.

6846837, Jan 25, 2005

Jun 21, 2002

10/178074

Howard I. Maibach - San Francisco CA, US
Eric C. Luo - Plano TX, US
Tsung-Min Hsu - San Diego CA, US

A61K 3300, A61K 3302, A61K 3308, A61K 31137, A61K 314412

514350, 514 31, 514159, 514161, 514162, 514163, 514164, 5142395, 514252, 514269, 514274, 514346, 514383, 514384, 514396, 514399, 514400, 514462, 514557, 514558, 514560, 514568, 514588, 514648, 514649, 514717, 514738, 514858, 514937, 514944, 514946, 514947, 514964, 514969, 424411, 424445, 424447, 424448, 424449, 424484, 424670, 424682, 424688, 424690, 424692, 424693, 424719, 424722

Methods and topical pharmaceutical formulations are provided for the treatment of nail fungus (onychomycosis). The invention involves a pharmacologically active antifungal agent, plus a pharmaceutically acceptable base in a formulation having a pH of 7. 5 to about 13. 0, preferably about 8. 0 to 11. 5, and most preferably about 8. 5 to 10. 5. These basic formulations permeate the nail and are effective in treating fungal infections of the nail and surrounding tissues.

6943197, Sep 13, 2005

Jun 21, 2002

10/176962

Howard I. Maibach - San Francisco CA, US
Eric C. Luo - Plano TX, US
Tsung-Min Hsu - San Diego CA, US

A61K033/00

514887, 424600, 424688, 424690, 424693, 514886

Provided are methods and topical pharmaceutical formulations for the treatment of inflammatory dermatoses. The invention involves the topical administration of a pharmacologically active base in a formulation having a pH of about 7. 5 to about 13. 0, preferably about 8. 0 to 11. 5, and most preferably about 8. 5 to 10. 5. These basic formulations are particularly suited to the treatment of acne vulgaris.

2003007, Apr 17, 2003

Jun 21, 2002

10/178082

Howard Maibach - San Francisco CA, US
Eric Luo - Plano TX, US
Tsung-Min Hsu - San Diego CA, US

A61K007/42, A61K007/135

424/059000, 424/062000

Provided is a topical pharmaceutical composition for skin lightening, which is particularly useful in treating skin hyperpigmentation, together with methods for its use. The composition and methods involve the topical use of an active agent effective in the treatment of skin hyperpigmentation plus a permeation-enhancing base that, in one embodiment, gives the composition a pH of about 8.0 to about 13.0, preferably about 8.0 to 11.5, and most preferably about 8.5 to 10.5.

2003007, Apr 17, 2003

Jun 21, 2002

10/176948

Howard Maibach - San Francisco CA, US
Eric Luo - Plano TX, US
Tsung-Min Hsu - San Diego CA, US

A61K033/08, A61K033/02, A61K033/00

424/722000, 424/688000, 424/721000

Provided is a topical pharmaceutical composition for the treatment of warts, together with methods for its use. The composition and methods involve the topical use of an active agent effective in the treatment of warts plus a permeation-enhancing base that, in one embodiment, gives the composition a pH of about 8.0 to about 13.0, preferably about 8.0 to 11.5, and most preferably about 8.5 to 10.5. This composition can be used to treat human papilloma virus infections, particularly cutaneous warts.