Inventors:
Peter I. Lelkes - Cherry Hill NJ, US
Mengyan Li - Philadelphia PA, US
Anat Perets - Narbeth PA, US
Honesto Poblete - Philadelphia PA, US
Philip Lazarovici - Jerusalem, IL
Assignee:
DREXEL UNIVERSITY - Philadelphia PA
International Classification:
A61K 35/12, C12N 5/00, C12N 5/06
US Classification:
424572, 435398, 435325, 20415715, 977923
Abstract:
Methods of making a biologically active three-dimensional scaffold capable of supporting growth and differentiation of a cell are described. Biologically active three-dimensional scaffold made by the methods of the invention and an engineered tissue made from the scaffolds are described. Fibers of desired porosity can be obtained from non-structural ECM by lyophilization and/or electrospinning which can be useful for numerous tissue engineering applications requiring complex scaffolds, such as wound healing, artificial skin (burns), soft tissue replacement/repair and spinal cord injury.