Inventors:
Elijah M. Bolotin - Buffalo Grove IL, US
Gilbert J. Grant - White Plains NY, US
Yechezkel Barenholz - Jerusalem, IL
Herman Turndorf - New York NY, US
Boris Piskoun - Brooklyn NY, US
Assignee:
New York University - New York NY
Yissum Research Development, Co - Jerusalem
International Classification:
A61K 9/127
Abstract:
Liposomal bupivacaine compositions are prepared using an ammonium sulfate gradient loading procedure, at a pH which prevents precipitation of the drug from the loading solution. Also described are liposome suspensions comprising ‘GMV’ (giant multivesicular) liposomes and methods for their preparation. The liposomal compositions are characterized by high drug-to-lipid ratios and provide long term analgesia.