HERMAN EUGENE GRIFFIN
Veterinary in Wakefield, RI

6613325, Sep 2, 2003

Jun 1, 2000

09/585030

Michael J. Amery - Washington Crossing PA
Paul Sibbons - Harrow, GB
Stuart Burnett - Liverpool, GB
Sally-Anne Rickets - Amersham, GB
Peter A. D. Edwardson - Leeds, GB
Jonathan Hughes - Buckinghamshire, GB
Derek A. Hollingsbee - Neston, GB
Stewart A. Cederholm-Williams - Oxford, GB
Horace R. Trumbull - Skillman NJ
Herman Eugene Griffin - Wakefield RI

Bristol-Myers Squibb Company - New York NY

A61K 3848

424 9464, 424 7806, 424 77, 424423, 424422

In accordance with the present invention it has been found that a fibrin polymer film formed by applying materials most closely resembling the natural clotting materials to a surgical adhesion formation. Preferred embodiments involve application of a fibrin monomer under polymerizing conditions to the surgical wound site. Unexpectedly, in addition to this improved prevention of adhesions, the more chemically-natural clots, especially the fibrin-monomer based fibrin polymer, also functions as a fibrin sealant, i. e. , has adherence, provides hemostasis and promotes wound healing while also functioning as a barrier. In preferred embodiments the novel methods of this invention conveniently use one or more plasma proteins derived from the patients own blood as to be autologous. Further, the sealant material is preferably substantially free of any added or exogenous enzymes, e. g. , thrombin, etc.