HERBERT L BONKOVSKY, MD
Osteopathic Medicine in Winston Salem, NC
License number
North Carolina 037512
Category
Osteopathic Medicine
Type
Gastroenterology
License number
North Carolina 2008-00082
Category
Osteopathic Medicine
Type
Gastroenterology
Address
Address
2
1 Medical Center Dr, Winston Salem, NC 27157
2214 Cumberland Ave, Charlotte, NC 28203
2214 Cumberland Ave, Charlotte, NC 28203
Phone
(336) 713-7306
(704) 307-4956
(704) 307-4956
Organization information
See more information about HERBERT L BONKOVSKY at bizstanding.comCarolinas Medical Center - Herbert L Bonkovsky MD
1000 Blythe Blvd, Charlotte, NC 28203
Categories:
Gastroenterology Physicians & Surgeons
Phone:
(704) 355-2000 (Phone)
Professional information
Herbert L Bonkovsky, Charlotte NC
Specialties:
Gastroenterologist
Address:
1437 Scott Ave, Charlotte, NC 28203
1350 S Kings Dr, Charlotte, NC 28207
1000 Blythe Blvd, Charlotte, NC 28203
1350 S Kings Dr, Charlotte, NC 28207
1000 Blythe Blvd, Charlotte, NC 28203
Education:
Case Western Reserve University, School of Medicine - Doctor of Medicine
Board certifications:
American Board of Internal Medicine Certification in Internal Medicine, American Board of Internal Medicine Sub-certificate in Gastroenterology (Internal Medicine)
Herbert Lloyd Bonkovsky, Charlotte NC
Specialties:
Internal Medicine, Gastroenterology, Hepatology
Work:
Carolinas Medical Center
1350 S Kings Dr, Charlotte, NC 28207 Gastroenterology Associates
263 Farmington Ave, Farmington, CT 06032 Carolinas Medical Center
1000 Blythe Blvd, Charlotte, NC 28203 The Liver-Biliary-Pancreatic Center and Center for Digestive and Metabolic Disorders
1437 Scott Ave, Charlotte, NC 28203
1350 S Kings Dr, Charlotte, NC 28207 Gastroenterology Associates
263 Farmington Ave, Farmington, CT 06032 Carolinas Medical Center
1000 Blythe Blvd, Charlotte, NC 28203 The Liver-Biliary-Pancreatic Center and Center for Digestive and Metabolic Disorders
1437 Scott Ave, Charlotte, NC 28203
Education:
Case Western Reserve University(1967)
Dr. Herbert Bonkovsky, Charlotte NC - MD (Doctor of Medicine)
Specialties:
Gastroenterology
Address:
Carolina Medical Center TRA
1025 Morehead Medical Dr SUITE 600, Charlotte 28204
(704) 355-6649 (Phone)
1025 Morehead Medical Dr SUITE 600, Charlotte 28204
(704) 355-6649 (Phone)
Languages:
English
Hospitals:
Carolina Medical Center TRA
1025 Morehead Medical Dr SUITE 600, Charlotte 28204
Carolinas Medical Center
1000 Blythe Blvd, Charlotte 28203
1025 Morehead Medical Dr SUITE 600, Charlotte 28204
Carolinas Medical Center
1000 Blythe Blvd, Charlotte 28203
Education:
Medical School
Case Western Reserve Univ Sch Of Med
Graduated: 1967
Duke University Hospital
Graduated: 1968
Cleveland Metropolitan General Hospital
Graduated: 1969
Dartmouth Affil Hosps
Graduated: 1973
Case Western Reserve Univ Sch Of Med
Graduated: 1967
Duke University Hospital
Graduated: 1968
Cleveland Metropolitan General Hospital
Graduated: 1969
Dartmouth Affil Hosps
Graduated: 1973
Treating Hepatitis C Virus Infection With Over-Expression Of Microrna-196
US Patent:
2011011, May 19, 2011
Filed:
Oct 8, 2009
Appl. No.:
12/575884
Inventors:
Herbert L. Bonkovsky - Charlotte NC, US
Weihong Hou - Weddington NC, US
Weihong Hou - Weddington NC, US
International Classification:
A61K 9/127, A61K 31/7105, A61K 38/21, C12N 5/071, A61P 31/14
US Classification:
424450, 514 44 A, 424 856, 435370
Abstract:
The present invention is directed to methods of treating cells infected with HCV and mammals suffering from HCV infection by transfecting the infected cells with miRNA-196 mimic. miRNA-196 mimic significantly down-regulates Bach1 protein and HCV gene expression, while also up-regulating HMOX1 gene expression. miRNA-196 binds with the 3′-UTR of Bach1 mRNA to reduce the expression of Bach1. As such, miRNA-196 can play an important role in the regulation of HCV replication and HMOX1/Bach1 expression in hepatocytes. The present invention also provides a formulation for the treatment of cells expressing HCV comprising a therapeutically effective amount of miRNA-196 such that Bach1 and HCV gene expression are down-regulated while HMOX1 expression is increased. The formulations are adapted to enable the transfection of miRNA-196 mimic into hepatocytes expressing HCV proteins.
Treatment Of Hepatitis C Infection With Metalloporphyrins
US Patent:
2010008, Apr 8, 2010
Filed:
Oct 2, 2009
Appl. No.:
12/572651
Inventors:
Herbert L. Bonkovsky - Charlotte NC, US
Weihong Hou - Weddington NC, US
Weihong Hou - Weddington NC, US
International Classification:
A61K 38/21, A61K 31/555, A61P 31/14
US Classification:
424 854, 514185
Abstract:
The present invention is directed to the treatment of hepatitis C infection with a metalloporphyrin. In particular, the present invention is based on the discovery that the NS5A protein plays a key role in HCV RNA replication by participating in polyprotein cleavage, interferon response and cellular signaling pathways. It has been found that metalloporphyrins, such as zinc porphyrins, induce post-translational down-regulation of HCV NS5A protein in an ubquitin-proteasome degradation pathway. That is, metalloporphyrins can be used to activate the ubiquitin-proteasomal pathway of NS5A protein catabolism. As a result, metalloporphyrins can be used to significantly suppress HCV viral replication in HCV infected cells.