HENRY LAURIS PAULSON
Medical Practice in Iowa City, IA
License number
Pennsylvania MD048834L
Category
Medicine
Type
Medical Physician and Surgeon
Address
Address
2
Iowa City, IA 52245
Pennsylvania
Pennsylvania
Personal information
See more information about HENRY LAURIS PAULSON at radaris.comName
Address
Phone
416 Linn St, Iowa City, IA 52245
240B Emrb, Iowa City, IA 52240
Professional information
See more information about HENRY LAURIS PAULSON at trustoria.com
Methods And Compositions For Suppression Of Neurodegeneration
Methods And Compositions For Suppression Of Neurodegeneration
US Patent:
2003015, Aug 21, 2003
Filed:
Oct 28, 2002
Appl. No.:
10/283409
Inventors:
Nancy Bonini - Narberth PA, US
Henry Paulson - Iowa City IA, US
Henry Paulson - Iowa City IA, US
International Classification:
A61K038/43
US Classification:
424/094100
Abstract:
Methods for changing solubility of expanded polyglutamine protein, suppressing polyglutamine toxicity, and treating neurodegenrative disorder by administering to the subject a Hsp40 chaperone or an agent which increases expression or activity of a Hsp40 chaperone, preferably in combination with a Hsp70 chaperone or an agent which increases expression or activity of a Hsp70 chaperone are provided. Also provided are compositions for treating neurodegenrative disorders containing a Hsp40 chaperone or an agent which increases activity or expression of a Hsp40 chaperone and a Hsp70 chaperone or an agent which increases activity or expression of a Hsp70 chaperone as well as methods for identifying such agents.
Rna Interference Suppresion Of Neurodegenerative Diseases And Methods Of Use Thereof
Rna Interference Suppresion Of Neurodegenerative Diseases And Methods Of Use Thereof
US Patent:
8524879, Sep 3, 2013
Filed:
May 5, 2010
Appl. No.:
12/774019
Inventors:
Beverly L. Davidson - North Liberty IA, US
Haibin Xia - Iowa City IA, US
Qinwen Mao - Iowa City IA, US
Henry Paulson - Iowa City IA, US
Ryan L. Boudreau - Iowa City IA, US
Scott Harper - Iowa City IA, US
Haibin Xia - Iowa City IA, US
Qinwen Mao - Iowa City IA, US
Henry Paulson - Iowa City IA, US
Ryan L. Boudreau - Iowa City IA, US
Scott Harper - Iowa City IA, US
Assignee:
University of Iowa Research Foundation - Iowa City IA
International Classification:
C07H 21/04
US Classification:
536 245, 536 2431, 536 241
Abstract:
The present invention is directed to small interfering RNA molecules (siRNA) targeted against nucleic acid sequence that encodes huntingtin or ataxin-1, and methods of using these siRNA molecules.
Rna Interference Suppression Of Neurodegenerative Diseases And Methods Of Use Thereof
Rna Interference Suppression Of Neurodegenerative Diseases And Methods Of Use Thereof
US Patent:
2008027, Nov 6, 2008
Filed:
Jun 2, 2005
Appl. No.:
11/597225
Inventors:
Beverly L. Davidson - North Liberty IA, US
Habin Xia - Iowa City IA, US
Qinwen Mao - Iowa City IA, US
Henry Paulson - Iowa City IA, US
Ryan Boudreau - Iowa City IA, US
Habin Xia - Iowa City IA, US
Qinwen Mao - Iowa City IA, US
Henry Paulson - Iowa City IA, US
Ryan Boudreau - Iowa City IA, US
Assignee:
UNIVERSITY OF IOWA RESEARCH FOUNDATION - Iowa City IA
International Classification:
A61K 31/7105, C07H 21/02, C12N 15/63, A61P 25/28, C12N 5/06, A01K 67/027
US Classification:
514 44, 536 231, 4353201, 435325, 800 14, 435375, 536 245
Abstract:
The present invention is directed to small interfering RNA molecules (siRNA) targeted against nucleic acid sequence that encodes huntingtin or ataxin-1, and methods of using these siRNA molecules.
Rna Interference Suppression Of Neurodegenerative Diseases And Methods Of Use Thereof
Rna Interference Suppression Of Neurodegenerative Diseases And Methods Of Use Thereof
US Patent:
8481710, Jul 9, 2013
Filed:
Dec 9, 2010
Appl. No.:
12/963793
Inventors:
Beverly L. Davidson - Iowa City IA, US
Haibin Xia - Iowa City IA, US
Qinwen Mao - Iowa City IA, US
Henry Paulson - Iowa City IA, US
Ryan Boudreau - Iowa City IA, US
Scott Harper - Iowa City IA, US
Haibin Xia - Iowa City IA, US
Qinwen Mao - Iowa City IA, US
Henry Paulson - Iowa City IA, US
Ryan Boudreau - Iowa City IA, US
Scott Harper - Iowa City IA, US
Assignee:
University of Iowa Research Foundation - Iowa City IA
International Classification:
C07H 21/04
US Classification:
536 245, 536 2431, 536 241
Abstract:
The present invention is directed to small interfering RNA molecules (siRNA) targeted against nucleic acid sequence that encodes huntingtin or ataxin-1, and methods of using these siRNA molecules.
Suppressing Polyglutamine Aggregation And Toxicity
Suppressing Polyglutamine Aggregation And Toxicity
US Patent:
2007024, Oct 18, 2007
Filed:
Jan 22, 2007
Appl. No.:
11/656048
Inventors:
Henry Paulson - Iowa City IA, US
Victor Miller - Jacksonville FL, US
Victor Miller - Jacksonville FL, US
International Classification:
A61K 38/07, A61K 38/06, A61P 25/28, C12N 5/06, C12N 5/08, C12N 5/10
US Classification:
514018000, 435375000
Abstract:
It has been discovered that CHIP suppresses polyglutamine aggregation and toxicity in transfected cell lines, primary neurons and a novel zebrafish model of disease. Accordingly, certain embodiments of the present invention provide methods for decreasing the formation of an inclusion or aggregation of a protein or for increasing the solubility of a protein in a cell, comprising increasing the amount of C-terminal heat shock protein 70-interacting protein (CHIP) or a functional subunit of CHIP in the cell. Additionally, certain embodiments of the present invention provide methods for treating a subject that has a neurodegenerative disease or preventing a neurodegenerative disease in a subject, comprising administering to the subject a treatment effective to increase the amount of CHIP, or a functional subunit thereof, in cells of the subject.
Sirna-Mediated Gene Silencing
Sirna-Mediated Gene Silencing
US Patent:
2004024, Dec 2, 2004
Filed:
Dec 16, 2003
Appl. No.:
10/738642
Inventors:
Beverly Davidson - North Liberty IA, US
Henry Paulson - Iowa City IA, US
Victor Miller - Iowa City IA, US
Cynthia Gouvion - Iowa City IA, US
Henry Paulson - Iowa City IA, US
Victor Miller - Iowa City IA, US
Cynthia Gouvion - Iowa City IA, US
International Classification:
C12N015/85
US Classification:
435/455000, 435/325000
Abstract:
The present invention is directed to small interfering RNA molecules (siRNA) targeted against an allele of interest, and methods of using these siRNA molecules.
Sirna-Mediated Gene Silencing
Sirna-Mediated Gene Silencing
US Patent:
2013006, Mar 14, 2013
Filed:
Nov 5, 2012
Appl. No.:
13/668739
Inventors:
University of Iowa Research Foundation - Iowa City IA, US
Henry Paulson - Iowa City IA, US
Victor Miller - Iowa City IA, US
Cynthia Gouvion - Iowa City IA, US
Henry Paulson - Iowa City IA, US
Victor Miller - Iowa City IA, US
Cynthia Gouvion - Iowa City IA, US
Assignee:
UNIVERSITY OF IOWA RESEARCH FOUNDATION - Iowa City IA
International Classification:
C12N 5/071
US Classification:
435325
Abstract:
The present invention is directed to small interfering RNA molecules (siRNA) targeted against an allele of interest, and methods of using these siRNA molecules.
Sirna-Mediated Gene Silencing
Sirna-Mediated Gene Silencing
US Patent:
2011024, Oct 6, 2011
Filed:
Nov 23, 2010
Appl. No.:
12/952449
Inventors:
Beverly L. Davidson - Iowa City IA, US
Henry Paulson - Iowa City IA, US
Victor Miller - Iowa City IA, US
Cynthia Gouvion - Iowa City IA, US
Henry Paulson - Iowa City IA, US
Victor Miller - Iowa City IA, US
Cynthia Gouvion - Iowa City IA, US
Assignee:
University of Iowa Research Foundation - Iowa City IA
International Classification:
C12N 5/10, C07H 21/04, C12N 15/63, C12N 1/00
US Classification:
435325, 536 245, 4353201, 435243, 435419
Abstract:
The present invention is directed to small interfering RNA molecules (siRNA) targeted against an allele of interest, and methods of using these siRNA molecules.
Allele-Specific Silencing Of Disease Genes
Allele-Specific Silencing Of Disease Genes
US Patent:
2009010, Apr 23, 2009
Filed:
May 26, 2003
Appl. No.:
10/522954
Inventors:
Beverly L. Davidson - North Liberty IA, US
Victor Miller - Iowa City IA, US
Henry Paulson - Iowa City IA, US
Pedro Gonzalez-Alegre - Iowa City IA, US
Scott Harper - Iowa City IA, US
Victor Miller - Iowa City IA, US
Henry Paulson - Iowa City IA, US
Pedro Gonzalez-Alegre - Iowa City IA, US
Scott Harper - Iowa City IA, US
Assignee:
UNIVERSITY OF IOWA RESEARCH FOUNDATION - Iowa City IA
International Classification:
A61K 31/7105, C12N 5/10, A61P 25/28, C07H 21/02
US Classification:
514 44, 530325, 536 245
Abstract:
The present invention is directed to small interfering RNA molecules (siRNA) targeted against an allele of interest, and methods of using these siRNA molecules.
Allele-Specific Silencing Of Disease Genes
Allele-Specific Silencing Of Disease Genes
US Patent:
2008017, Jul 24, 2008
Filed:
Jan 31, 2006
Appl. No.:
11/343366
Inventors:
Beverly L. Davidson - North Liberty IA, US
Scott Harper - Iowa City IA, US
Pedro Gonzalez-Alegre - Iowa City IA, US
Victor Miller - Iowa City IA, US
Henry Paulson - Iowa City IA, US
Scott Harper - Iowa City IA, US
Pedro Gonzalez-Alegre - Iowa City IA, US
Victor Miller - Iowa City IA, US
Henry Paulson - Iowa City IA, US
International Classification:
A61K 31/70, C12N 5/06, C12N 15/11, C12N 15/87, A61P 43/00, C12Q 1/68, C12N 15/00, A01K 67/027
US Classification:
514 44, 435325, 536 231, 4353201, 800 13, 435455, 435 6
Abstract:
The present invention is directed to small interfering RNA molecules (siRNA) targeted against an allele of interest, and methods of using these siRNA molecules.