Inventors:
Henry Joseph Horacek - Charlotte NC, US
Min Michael He - Ellicott City MD, US
Moise A. Khayrallah - Morrisville NC, US
International Classification:
A61K 9/14, A61K 31/4168, C07D 233/50, A61P 9/12, A61P 9/04, A61P 25/06, A61P 25/02, A61P 25/30, A61P 3/04, A61P 25/18
Abstract:
A composition and method of treating adrenergic dysregulation by administering the composition is disclosed, wherein the composition comprises a α-adrenergic receptor agonist; a pharmaceutically acceptable hydrophilic matrix and a release-retardant of a metal alkyl sulfate. In embodiments, the composition provides a sustained release of the agonist, wherein after administration of the composition no more than once about every 12 hours (e.g., no more than once about every 24 hours) to a subject having a steady state plasma concentration of the α-adrenergic receptor agonist, the agonist's plasma concentration peak-to-trough ratio is no greater than about 1.9.