Henry J. Kaplan
Medical Practice in Louisville, KY
License number
Kentucky 36464
Issued Date
Apr 10, 2001
Expiration Date
Feb 28, 2018
Category
Ophthalmology
Type
Faculty
Address
Address
301 E. Kentucky Lions Eye Ctr , 301 E Muhammad Ali Blvd, Louisville, KY 40202
Education
Cornell University Medical College, 1968
Phone
(502) 852-3716 (Work)
Personal information
See more information about Henry J. Kaplan at radaris.comName
Address
Phone
1400 Willow Ave, Louisville, KY 40204
Organization information
See more information about Henry J. Kaplan at bizstanding.comEye Specialists Of Louisville - Tongalp H Tezel MD
301 E Muhammad Ali Blvd, Louisville, KY 40202
Doing business as:
Eye Specialists Of Louisville - Charles C Barr MD<br>Eye Specialists Of Louisville - Judith Mohay MD<br>Eye Specialists Of Louisville - Paul J Rychwalski MD<br>Eye Specialists Of Louisville - Shlomit Schaal MD<br>Eye Specialists Of Louisville - Henry J Kaplan MD<br>Eye Specialists Of Louisville - Hassan A Shah MD<br>Eye Specialists Of Louisville - Gary N Foulks MD<br>Eye Specialists Of Louisville - Joern Soltau MD<br>Eye Specialists Of Louisville - Rahul Bhola MD<br>Eye Specialists Of Louisville - Mark Krakauer MD
Phone:
(502) 852-5466 (Phone)
Categories:
General Surgeons, Ophthalmology Physicians & Surgeons, Physicians & Surgeons, ...
Open Hours:
24 Hour Answering
Products:
Cornea & External Disease, Glaucoma Service and Surgery
Additional:
Cornea & External Disease
Professional information
Inhibition Of Wet Type Age Related Macular Degeneration (Amd) By Adiponectin Or Acrp 30
US Patent:
7964557, Jun 21, 2011
Filed:
Mar 22, 2006
Appl. No.:
11/910188
Inventors:
Puran S. Bora - Little Rock AR, US
Nalini S. Bora - Little Rock AR, US
Henry J. Kaplan - Louisville KY, US
Nalini S. Bora - Little Rock AR, US
Henry J. Kaplan - Louisville KY, US
Assignee:
University of Louisville Research Foundation, Inc. - Louisville KY
International Classification:
A61K 38/00, A61K 47/00, A61K 49/00, A61P 27/02, C07K 7/00
US Classification:
514 11, 514 12, 514 13, 514 133, 514 208, 424 934, 530300
Abstract:
The present invention provides new methods of treating wet type of age related macular degeneration by administering adiponectin (APN) or a functional fragment derived therefrom. One of the pathological complications of age related macular degeneration (AMD) is choroidal angiogenesis or choroidal neovascularization (CNV). The inventors discovered that the level of APN expression is significantly lower in the choroids of the laser-induced mouse model of choroidal angiogenesis or choroidal neovascularization (CNV) than that of the control mice and that administration of recombinant adiponectin (rAPN) or a peptide derived from the globular domain of the intact APN protein to the mouse model of CNV reduced the size of CNV significantly. These studies are the first to demonstrate the inhibitory effect of adiponectin on choroidal angiogenesis and thus provide the basis for treating a condition or disease involving angiogenesis, particularly age related macular degeneration, with administration of adiponectin.
Subretinal Implantation Device And Surgical Cannulas For Use Therewith
US Patent:
7189245, Mar 13, 2007
Filed:
Feb 14, 2003
Appl. No.:
10/367353
Inventors:
Henry J. Kaplan - Louisville KY, US
Assignee:
Photogenesis, Inc. - Los Angeles CA
International Classification:
A61F 9/00
US Classification:
606107
Abstract:
An implantation device having a reservoir for holding a solid or semisolid implant and a carrier fluid, wherein the reservoir includes a cannula. The cannula has a tip end and a delivery opening therein both shaped and dimensioned to suit the application. For example, an implant (such as a retinal cell graft) and suitable carrier fluid (such as an aqueous hyaluronic acid solution) can be expressed from the opening into the subretinal space of a recipient eye, provided the cannula is of sufficient length that the tip end can reach the subretinal space while the remainder of the fluid reservoir is external of the eye. Expression of the carrier fluid from the reservoir via the delivery opening expels the implant through the delivery opening. An electromechanically driven plunger apparatus with operator controls is provided in a preferred embodiment.
Layered Bio-Adhesive Compositions And Uses Thereof
US Patent:
2010002, Feb 4, 2010
Filed:
Apr 24, 2007
Appl. No.:
12/298698
Inventors:
Lucian V. Del Priore - Basking Ridge NJ, US
Henry J. Kaplan - Louisville KY, US
Tongalp Tezel - Louisville KY, US
Henry J. Kaplan - Louisville KY, US
Tongalp Tezel - Louisville KY, US
Assignee:
UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. - Louisville KY
International Classification:
A61K 35/44, C09J 7/02, A61K 9/70, A61F 13/00, A61P 27/02, A61K 47/42, A61K 47/36, A61K 47/34, A61K 47/26, A61P 17/02
US Classification:
424443, 428337, 424 937, 5147723, 5147727, 514774, 514773, 514777, 523118
Abstract:
The invention generally provides compositions and methods for promoting and enhancing wound closure and healing. Specifically, the invention provides a biologic composition which comprises a support layer which serves as transport scaffold, for example made of gelatin, which is coated or impregnated with a bio-adhesive molecule such as rose bengal or glyceraldehyde. The composition can also comprise an artificial or biological matrix, optionally processed (i.e. cleaned and coated with extracellular matrix proteins) to enhance cell attachment and survival. The composition can further comprise a monolayer of epithelial, endothelial cells or mesenchymal cells. The invention provides methods for using the compositions for treating wounds due to disease, trauma or surgery. Specific methods for treating ocular wounds are provided.
Methods And Compositions For Modulating Ocular Damage
US Patent:
2013017, Jul 11, 2013
Filed:
May 20, 2011
Appl. No.:
13/698518
Inventors:
Tongalp H. Tezel - Louisville KY, US
Henry J. Kaplan - Louisville KY, US
Robert A. Mitchell - Louisville KY, US
John O. Trent - Louisville KY, US
Henry J. Kaplan - Louisville KY, US
Robert A. Mitchell - Louisville KY, US
John O. Trent - Louisville KY, US
Assignee:
UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. - Louisville KY
International Classification:
A61K 39/395, A61K 31/505
US Classification:
4241331, 514256, 4241451
Abstract:
Methods for modulating eye damage associated with a disease or disorder, and/or damage incident to trauma including but not limited to trauma associated with ocular surgery are provided. In some embodiments, the methods include administering an effective amount of a modulator of a migration inhibitory factor (MIF) polypeptide biological activity to a subject. Also provided are methods for modulating the severity of delaying the onset of and/or inhibiting and/or preventing the development of an ocular disease, and methods for modulating the severity of delaying the onset of and/or inhibiting and/or preventing the development of scarring and/or other consequence of wound healing incident to ocular surgery, as well as modulating the survival, function, and/or differentiation of engrafted cells that can be employed as part of tissue engineering procedures to correct structural, functional, and/or cellular defects of the eye.
Method And System For Monitoring A Condition Of An Eye
US Patent:
2010001, Jan 21, 2010
Filed:
Jul 16, 2008
Appl. No.:
12/174458
Inventors:
John F. Naber - Goshen KY, US
Douglas J. Jackson - New Albany IN, US
Henry J. Kaplan - Louisville KY, US
Julia Aebersold - Floyds Knobs IN, US
Kevin Walsh - Louisville KY, US
Robert S. Keynton - Louisville KY, US
Thomas Roussel - Louisville KY, US
Paul van der Pol - Louisville KY, US
Douglas J. Jackson - New Albany IN, US
Henry J. Kaplan - Louisville KY, US
Julia Aebersold - Floyds Knobs IN, US
Kevin Walsh - Louisville KY, US
Robert S. Keynton - Louisville KY, US
Thomas Roussel - Louisville KY, US
Paul van der Pol - Louisville KY, US
International Classification:
A61B 3/16
US Classification:
600398
Abstract:
A method, system, and computer-readable medium are provided which monitor a condition of an eye. The system includes a communication interface and a processor operably coupled to the communication interface. The communication interface is configured to receive an intraocular pressure measurement datum and a time datum associated with the time the intraocular pressure measurement was measured using an eye measurement system. The processor is configured to receive the intraocular pressure measurement datum and the time datum, to receive a dispensed amount datum associated with an amount of a drug administered to an eye of a user and a second time datum associated with the time the drug was administered, and to store the received intraocular pressure measurement datum, the received time datum, the received dispensed amount datum, and the received second time datum to monitor a condition of the eye.
Medical Devices And Methods For Modulating Cell Adhesion
US Patent:
2005022, Oct 13, 2005
Filed:
Sep 17, 2004
Appl. No.:
10/943728
Inventors:
Lucian Del Priore - Basking Ridge NJ, US
Barbara McLaughlin - Omaha NE, US
Henry Kaplan - Louisville KY, US
Nalini Bora - Louisville KY, US
Barbara McLaughlin - Omaha NE, US
Henry Kaplan - Louisville KY, US
Nalini Bora - Louisville KY, US
International Classification:
A61K039/395
US Classification:
424144100, 424423000
Abstract:
The present invention provides a medical device for use in inhibiting adhesion of cells. The medical device has a coating comprising a CD46 inhibitor. In one embodiment, the coating further comprises an inhibitor of β integrin. Also provided is a use of the medical device in a method for inhibiting adhesion of cells. The present invention further provides methods for inhibiting cell-substrate and cell-cell adhesion. Also provided are uses of CD46 inhibitors in these methods. Additionally, the present invention provides methods for promoting cell-substrate and cell-cell adhesion.
Hemoglobin-Based Methods For Prophylaxis, Diagnosis And/Or Treatment Of Retinal Disorders
US Patent:
2011015, Jun 30, 2011
Filed:
Feb 25, 2011
Appl. No.:
13/035272
Inventors:
Tongalp H. Tezel - Louisville KY, US
Henry J. Kaplan - Louisville KY, US
Jon Klein - Louisville KY, US
Henry J. Kaplan - Louisville KY, US
Jon Klein - Louisville KY, US
Assignee:
UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. - Louisville KY
International Classification:
A61K 39/395, G01N 33/72, A61K 38/18, A61P 27/02
US Classification:
4241721, 436 66, 514 77
Abstract:
The presently disclosed subject matter provides methods of diagnosing retinal disorders in subjects by measuring hemoglobin and modified hemoglobin in the subjects. The presently disclosed subject matter further provides methods of treating retinal disorders in subjects by decreasing hypoxia in retinal tissue of the subjects through modulation of hemoglobin levels and activities in the retinal tissue.
Hemoglobin-Based Methods For Prophylaxis, Diagnosis And/Or Treatment Of Retinal Disorders
US Patent:
2009005, Feb 26, 2009
Filed:
Mar 26, 2007
Appl. No.:
12/294409
Inventors:
Tongalp H. Tezel - Louisville KY, US
Henry J. Kaplan - Louisville KY, US
Jon Klein - Louisville KY, US
Henry J. Kaplan - Louisville KY, US
Jon Klein - Louisville KY, US
Assignee:
UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. - Louisville KY
International Classification:
G01N 33/72, C12Q 1/00, A61K 38/00, A61K 39/395, A61P 27/00, A61B 5/05, A61B 17/20
US Classification:
436 67, 436 66, 435 4, 514 8, 4241721, 600407, 604 22
Abstract:
The presently disclosed subject matter provides methods of diagnosing retinal disorders in subjects by measuring hemoglobin and modified hemoglobin in the subjects. The presently disclosed subject matter further provides methods of treating retinal disorders in subjects by decreasing hypoxia in retinal tissue of the subjects through modulation of hemoglobin levels and activities in the retinal tissue.
Compositions And Methods For Reversing Age-Related Changes In Extracellular Matrix Proteins
US Patent:
2009004, Feb 19, 2009
Filed:
Aug 2, 2005
Appl. No.:
11/659151
Inventors:
Lucian V. Del Priore - Tarrytown NY, US
Tongalp Tezel - Louisville KY, US
Henry J. Kaplan - Louisville KY, US
Tongalp Tezel - Louisville KY, US
Henry J. Kaplan - Louisville KY, US
Assignee:
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK - New York NY
International Classification:
A61K 35/12, A61K 38/16, A61P 17/00, A61P 27/02, A61P 25/00
US Classification:
424 937, 514 12
Abstract:
The invention is directed to compositions and methods for reversing age-related changes in extracellular matrix proteins, particularly the collagen framework of basement membranes of various organs. The invention has particular application to age-related changes that impair Retinal Pigment Epithelium (RPE) cell repopulation of human Bruch's membrane.