Inventors:
Helen Vlassara - New York NY
Michael Brownlee - New York NY
Anthony Cerami - Shelter Island NY
Assignee:
The Rockefeller University - New York NY
International Classification:
A61K 4900, C12Q 100
Abstract:
The present invention relates to a method and associated agents for the inhibition and treatment of protein aging in animals by stimulating the bodies of the animals to increase their recognition and affinity for advanced glycosylation end products. Specifically, the method contemplates the administration of certain agents such as advanced glycosylation endproducts, such endproducts as are bound to the carrier, monokines that stimulate phagocytic cells to increase their activity toward advanced glycosylation endproducts, and mixtures of these materials either alone, or in conjunction with other co-stimulatory agents. Numerous diagnostic and therapeutic applications are defined, and pharmaceutical compositions are also contemplated.