HELEN H HOBBS, MD
Medical Practice at Harry Hines Blvd, Dallas, TX
License number
Texas G1435
Category
Medical Practice
Type
Clinical Molecular Genetics
Address
Address
5323 Harry Hines Blvd, Dallas, TX 75390
Phone
(214) 645-2868
(214) 648-1666 (Fax)
(214) 648-1666 (Fax)
Personal information
See more information about HELEN H HOBBS at radaris.comName
Address
Phone
101 E Skyline Acres, Wimberley, TX 78676
4096 De Zavala Rd #1207, San Antonio, TX 78249
5117 Palomar Ln, Dallas, TX 75229
PO Box 400, Chappell Hill, TX 77426
1023 Private Road 7015, Lexington, TX 78947
Organization information
See more information about HELEN H HOBBS at bizstanding.comMC Dermott Center - Helen H Hobbs MD
5323 Harry Hines Blvd, Dallas, TX 75390
Categories:
Physicians & Surgeons
Phone:
(214) 648-1600 (Phone)
Professional information
Drug Screen For Identifying An Agent That Modulates Low Density Lipoprotein Receptor Adaptin-Ligand Binding
US Patent:
6465196, Oct 15, 2002
Filed:
Mar 13, 2001
Appl. No.:
09/804778
Inventors:
Helen H. Hobbs - Dallas TX
Christine K. Garcia - Dallas TX
Robert I. Barnes - Frisco TX
Jonathan Cohen - Dallas TX
Christine K. Garcia - Dallas TX
Robert I. Barnes - Frisco TX
Jonathan Cohen - Dallas TX
Assignee:
Board of Regents, The University of Texas System - Austin TX
International Classification:
G01N 3353
US Classification:
435 71, 435 6, 436501
Abstract:
Low density lipoprotein receptor (LDRL) adaptin is a novel, key component of human cholesterol regulation, which provides a target for rational drug design and screening, therapeutic intervention, and diagnosis. Disclosed reagents include a variety of LDLR adaptin and LDLR adaptin PTB and CC domain compositions, including in vitro compositions comprising a natural human LDLR adaptin PTB domain and a ligand such as an NPXY (SEQ ID NO:7) peptide. These LDLR adaptin reagents are used, inter alia, in rational drug screening methods. The invention also provides polynucleotides encoding the subject LDLR adaptin polypeptides, including natural coding sequences, which may be used as probes or primers for detecting or amplifying LDLR adaptin genes and transcripts.
Abcg8 Vectors, Host Cells, And Method Of Making
US Patent:
6821750, Nov 23, 2004
Filed:
Nov 20, 2001
Appl. No.:
09/989981
Inventors:
Helen H. Hobbs - Dallas TX
Bei Shan - Redwood City CA
Robert Barnes - Frisco TX
Hui Tian - Foster City CA
Bei Shan - Redwood City CA
Robert Barnes - Frisco TX
Hui Tian - Foster City CA
Assignee:
Tularik Inc. - South San Francisco CA
Board of Regents, The University of Texas System - Austin TX
Board of Regents, The University of Texas System - Austin TX
International Classification:
C12N 1585
US Classification:
435 691, 4352523, 43525411, 4353201, 536 231, 536 235
Abstract:
The present invention provides nucleic acids encoding a novel ABC family cholesterol transporter, ABCG8. The herein-disclosed sequences can be used for any of a number of purposes, including for the diagnosis and treatment of cholesterol-associated disorders, including sitosterolemia, and for the identification of molecules that associate with and/or modulate the activity of ABCG8.
Helen H Hobbs, Dallas TX
Specialties:
Endocrinologist
Address:
5323 Harry Hines Blvd, Dallas, TX 75390
Education:
Case Western Reserve University, School of Medicine - Doctor of Medicine
Parkland Memorial Hospital - Fellowship - Endocrinology
Parkland Memorial Hospital - Residency - Internal Medicine
Parkland Memorial Hospital - Fellowship - Endocrinology
Parkland Memorial Hospital - Residency - Internal Medicine
Board certifications:
American Board of Internal Medicine Certification in Internal Medicine, American Board of Internal Medicine Sub-certificate in Endocrinology and Metabolism (Internal Medicine)
Professor, Internal Medicine And Molecular Genetics At Ut Southwestern
Position:
Professor, Internal Medicine and Molecular Genetics at UT Southwestern
Location:
Dallas/Fort Worth Area
Industry:
Research
Work:
UT Southwestern
-
Professor, Internal Medicine and Molecular Genetics
Dr. Helen H Hobbs, Dallas TX - MD (Doctor of Medicine)
Specialties:
Endocrinology, Diabetes & Metabolism, Endocrinology & Metabolism
Address:
5323 Harry Hines Blvd SUITE 8TH, Dallas 75390
(214) 645-0624 (Phone), (214) 648-1666 (Fax)
LIMITED TO OFFICIAL STATE DUTIES ONLY
5323 Harry Hines Blvd, Dallas 75390
(214) 648-7833 (Phone), (214) 648-6799 (Fax)
UNIVERSITY TEXAS SOUTHWESTERN MEDICAL CENTER
5323 Harry Hines Blvd SUITE E5, Dallas 75390
(214) 648-7588 (Phone), (214) 648-5477 (Fax)
(214) 645-0624 (Phone), (214) 648-1666 (Fax)
LIMITED TO OFFICIAL STATE DUTIES ONLY
5323 Harry Hines Blvd, Dallas 75390
(214) 648-7833 (Phone), (214) 648-6799 (Fax)
UNIVERSITY TEXAS SOUTHWESTERN MEDICAL CENTER
5323 Harry Hines Blvd SUITE E5, Dallas 75390
(214) 648-7588 (Phone), (214) 648-5477 (Fax)
Certifications:
Diabetes, Metabolism & Endocrinology, 1985, Internal Medicine, 1982
Awards:
Healthgrades Honor Roll
Languages:
English
Education:
Medical School
Case Western Reserve University School of Medicine
Graduated: 1979
Colum-Presby/Columbia U
Parkland/U Tex
Case Western Reserve University School of Medicine
Graduated: 1979
Colum-Presby/Columbia U
Parkland/U Tex
Methods For Detecting An Increased Risk For Coronary Heart Disease
US Patent:
2014005, Feb 27, 2014
Filed:
Jun 2, 2013
Appl. No.:
13/907923
Inventors:
Helen H. Hobbs - Dallas TX, US
Assignee:
Board of Regents, The University of Texas System - Dallas TX
International Classification:
C12Q 1/68
US Classification:
506 9, 435 611, 536 2431, 506 16
Abstract:
The invention relates generally to an allele on human chromosome 9 associated with increased risk for coronary heart disease and the use or detection of such an allele in determining whether a human has an increased risk for coronary heart disease. In one aspect, the invention relates to methods for detecting a predisposition or propensity or susceptibility for coronary heart disease in a human, comprising detecting the presence of an allele on human chromosome 9 that is associated with an increased risk for coronary heart disease in a human. Disclosed are methods and compositions for determining whether a person carries an allele associated with increased risk for coronary atherosclerosis by determining whether the person has an RA-CHR9 allele, such as by determining whether the person has an RA-CHR9 allele-associated single nucleotide polymorphism (SNP). The invention also relates to kits for detecting the presence of an allele on chromosome 9 associated with an increased risk for coronary heart disease.
Methods For Detecting An Increased Risk For Coronary Heart Disease
US Patent:
2008027, Nov 6, 2008
Filed:
May 2, 2008
Appl. No.:
12/151275
Inventors:
Jonathan C. Cohen - Dallas TX, US
Helen H. Hobbs - Dallas TX, US
Helen H. Hobbs - Dallas TX, US
International Classification:
C12Q 1/68
US Classification:
435 6
Abstract:
The invention relates generally to an allele on human chromosome 9 associated with increased risk for coronary heart disease and the use or detection of such an allele in determining whether a human has an increased risk for coronary heart disease. In one aspect, the invention relates to methods for detecting a predisposition or propensity or susceptibility for coronary heart disease in a human, comprising detecting the presence of an allele on human chromosome 9 that is associated with an increased risk for coronary heart disease in a human. Disclosed are methods and compositions for determining whether a person carries an allele associated with increased risk for coronary atherosclerosis by determining whether the person has an RA-CHR9 allele, such as by determining whether the person has an RA-CHR9 allele-associated single nucleotide polymorphism (SNP). The invention also relates to kits for detecting the presence of an allele on chromosome 9 associated with an increased risk for coronary heart disease.
Sequence Variations In Pnpla3 Associated With Hepatic Steatosis
US Patent:
2010005, Mar 4, 2010
Filed:
Sep 3, 2009
Appl. No.:
12/553330
Inventors:
Helen H. Hobbs - Dallas TX, US
Jonathan C. Cohen - Dallas TX, US
Jonathan C. Cohen - Dallas TX, US
International Classification:
C40B 30/00, C12Q 1/68
US Classification:
506 7, 435 6
Abstract:
Disclosed are methods of identifying a genetic variant in a person determined to have or be predisposed having a fatty liver by determining whether the person has PNPLA3-I148M. Also disclosed are methods of identifying a genetic variant in a person by determining whether the person has PNPLA3-I148M; and prescribing to the person a treatment to reduce liver fat or associated inflammation.
Methods For Modulation Of Lipid Uptake
US Patent:
5925333, Jul 20, 1999
Filed:
Nov 15, 1995
Appl. No.:
8/559505
Inventors:
Monty Krieger - Needham MA
Susan L. Acton - Jamaica Plain MA
Attilio Rigotti - Malden MA
Helen Haskell Hobbs - Dallas TX
Katherine Tallman Landschulz - Dallas TX
Susan L. Acton - Jamaica Plain MA
Attilio Rigotti - Malden MA
Helen Haskell Hobbs - Dallas TX
Katherine Tallman Landschulz - Dallas TX
Assignee:
Massachusetts Institute of Technology - Cambridge MA
Board of Regents, The University of Texas System - Austin TX
Board of Regents, The University of Texas System - Austin TX
International Classification:
C12N 1509, C12N 1579
US Classification:
424 91
Abstract:
Methods for regulation of lipid and cholesterol uptake are described which are based on regulation of the expression or function of the SR-BI HDL receptor. The examples demonstrate that estrogen dramatically downregulates SR-BI under conditions of tremendous upregulation of the LDL-receptor. The examples also demonstrate the upregulation of SR-BI in rat adrenal membranes and other non-placental steroidogenic tissues from animals treated with estrogen, but not in other non-placental non-steroidogenic tissues, including lung, liver, and skin. Examples further demonstrate the uptake of fluorescently labeled HDL into the liver cells of animal, which does not occur when the animals are treated with estrogen.
Common Allele On Chromosome 9 Associated With Coronary Heart Disease
US Patent:
2008027, Nov 6, 2008
Filed:
May 21, 2007
Appl. No.:
11/751563
Inventors:
Jonathan C. Cohen - Dallas TX, US
Helen H. Hobbs - Dallas TX, US
Helen H. Hobbs - Dallas TX, US
International Classification:
C12Q 1/68
US Classification:
435 6
Abstract:
Disclosed are methods and compositions for determining whether a person carries an allele associated with increased risk for coronary atherosclerosis by determining whether the person has had RA-CHR9 allel, such as by determining whether the person has an RA-CHR9 allele-associated single nucleotide polymorphism (SNP).